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The drug FK506 (tacrolimus, fujimycin) exerts its immunosuppressive effects by regulating the nuclear factor of the activated T-cell (NFAT) family of transcription factors. However, FK506 also exhibits neuroprotective effects, but its direct target proteins that mediate these effects have not been determined. To identify the target proteins responsible for FK506's neuroprotective effects, the drug

This paper explains election fraud historically in the case of Sweden, drawing on original data from second-instance election petitions filed in 1719–1908. These petitions reveal systematic procedural violations committed by local election officials toward the end of the Age of Liberty in the eighteenth century. By the mid-nineteenth century, however, fraud had been largely purged from Swedish ele

Purpose: This paper aims to discuss the current debates in facility management to understand where the research community is working and where the facility management sector and discipline might be heading. Design/methodology/approach: A review of research outputs has been undertaken to identify research themes. The discussion is based on developments that are already shaping how one should view f

Aim: The study was undertaken to explore whether shortening of striated muscle during activity is associated with release of bound Ca2+ into the myofibrillar space as has previously been proposed in order to explain the depressant effect of active shortening. Methods: The experiments were carried out on single muscle fibres isolated from the anterior tibialis muscle of Rana temporaria. The fibres

Even though anthropogenic nano-sized tungsten carbide nanoparticles (WC NPs) have been found in the environment, there are currently no investigations on their environmental fate. This work studies the interaction between natural organic matter (NOM) and WC NPs, as well as the potential uptake by the aquatic model organism Daphnia magna. We here show that the affinity between WC NPs and humic acid

Large Eddy Simulation (LES) was employed to investigate the flow field characteristics in an ethylene fueled scramjet combustor with a rearwall-expansion cavity in both non-reaction and reacting flows. The numerical solver was first validated against experiments and the numerical results were shown in reasonably good agreement with the available experimental data. Characteristics of the flow field

n this paper I will use concepts from innovation theory to analyse the work of the Court of Justice of the European Union in its important role as sole interpreter of EU law. In that regard, I define ‘innovator’ as one that facilitates use of new or existing inventions. Thus innovation is portrayed as a process in which several actors may contribute and where it all starts with an invention (the s

Older people with arrhythmias comprise a large group requiring complex care, posing many healthcare challenges. Rapid growth of the older population demands a better understanding of the needs of this patient group. The aim of this thesis was to investigate arrhythmia prevalence, incidence, survival, and experiences from the perspective of a geriatric population (aged 60+ years), and to examine th

Jordan population have increased 3 million in the last five years. 1.5Million are refugees from Syria. 800 thousand are inside refugeecamps in the northern part of Jordan. 100 thousand are situated inZaatari camp which is located 10 kilometres east of Mafraq city. Thisenormous influx increased solid waste volume generated by 480 tonsdaily. The additional waste generation has exacerbated pre-existi