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Epigenetic differences at immune and type 1 diabetes susceptibility genes in blood from young children after COVID-19 infection

Background: Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes (T1D), but potential underlying mechanisms remain unexplored. We evaluated whether COVID-19 or influenza A infection is characterized by differential DNA methylation at immune and T1D susceptibility genes in young children at risk for T1D. Methods: Epigenome-wide association analysis using t

Osteoarthritis year in review 2025 : Epidemiology and therapy

Aim: To summarise key epidemiological and therapeutic research on osteoarthritis (OA) published between April 2024 and March 2025. Methods: A narrative review was conducted using the MEDLINE database, focusing on English-language studies involving human participants published between April 1, 2024 and March 31, 2025. Eligible studies included observational longitudinal studies, systematic reviews,

Early Blight Infection and the Influence of Biocontrol Agents on Three Wild Potato Relatives : Implications for Integrated Pest Management (IPM) in Potato

Integrated pest management (IPM) is an important tool for sustainable crop production. IPM includes a diversity of methods, e.g., the use of biological control agents (BCAs) for disease control or growth promotion. While there is an increasing interest in the use of BCAs, less is known about their environmental costs and benefits on wild species, such as wild crop relatives. For example, a BCA may

Femoral neck fractures in adults with emphasis on surgical treatment

Femoral neck fractures (FNFs) are associated with loss of function in all ages and excess mortality. The societal costs are high. Treatment needs to be tailored based on fracture type, functional demand, and physiological age of the patient. Internal fixation is often preferred for undisplaced FNFs and for displaced FNFs in young patients. Anatomical reduction is essential, but slight valgus is ac

Gaps in Human Behaviour in Fires Research : A Scoping Review

When developing a research roadmap for human behaviour in fires, it is necessary to identify areas that require additional research. A general overview – from a multidisciplinary perspective – of gaps in human behaviour in fires research across multiple contexts is missing. The goal of this paper was to perform a scoping review to identify research gaps and themes in all aspects of human behaviour

Trajectories of pain recovery during the first 8 weeks after shoulder arthroplasty : results from the shoulder diary study using latent growth curve modeling

Background: Perioperative stress or discomfort in shoulder arthroplasty (SA) patients can be reduced using more individually tailored patient education and expectation management. Most published studies assess pain and function for the first time at 6 weeks or 3 months. Consequently, there is no thorough understanding of day-to-day recovery trajectories within the first postoperative weeks, hinder

Immunological effects of alpha-lactalbumin-enriched low-protein infant formula : A randomized controlled trial

Objectives: Breast-fed (BF) have lower risk of infections during infancy compared to those formula-fed (FF). A higher content of alpha-lactalbumin (α-lac) in breast milk, which may promote a more favorable gut microbiota, could be one reason. In this study, we evaluated whether increased concentration of α-lac in low-protein infant formula affects the immune response and the incidence of infection

Research efforts and gaps in the assessment of forest system resilience : A scoping review

This study investigates how the seven core resilience principles are integrated into assessments of forest system resilience to natural or human-induced disturbances across engineering, ecological, and social-ecological resilience concepts. Following PRISMA guidelines, a literature search in the Web of Science database using the keywords “resilience”, “forest” and “ecosystem services” yielded 1828

Copper Single-Atom Decorated Microfibrous Catalysts for Continuous-Flow Reduction of Nitroarenes

Continuous-flow fixed-bed reactors effectively bridge laboratory research and industrial production. As the key component, the catalyst module must demonstrate high catalytic activity and rapid reactant distribution to maximize the catalytic turnover. Herein, a facile strategy is proposed to fabricate a microfibrous catalyst by decorating Cu single atoms (Cu1) on composite microfiber (CMF) made fr

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In recent decades the average paternal age at childbirth has risen sharply. Many researchers from various disciplines are alarmed, as the offspring of older fathers have a higher risk of many diseases; however, previous studies lack a historical perspective. A new analysis shows that in many countries the current levels of average paternal age at childbirth were just as high in the past as today.

Validity and reliability of the Lithuanian Occupational Balance Questionnaire

Introduction: Occupational balance is an important concept in occupational therapy. However, no validated Occupational balance assessments currently exist in Lithuania. This study aimed to examine the psychometric properties of the Lithuanian version of the Occupational Balance Questionnaire 11 (OBQ11-LT). Method: A total of 127 healthy adults completed the OBQ11-LT to evaluate construct validity.

Healthcare professionals' perspectives on implementing the Swedish palliative care guide in geriatrics - a qualitative study using small-group and individual interviews

BACKGROUND: As the global population ages, the demand for palliative care is expected to increase. However, studies show that older patients often receive inadequate palliative care, partly due to healthcare professionals lacking sufficient training and tools to identify and address palliative care needs effectively. This study aims to explore healthcare professionals' experiences regarding facili

Circular Cities : Impacts on decarbonization and beyond

This study investigates the impacts of a range of interventions aimed at reducing in emissions in three high-impact sectors in cities: built environment, mobility, and sustainable energy systems. It does so by focusing on four cities around the world that are pioneering circular economy solutions (Bogotá, Glasgow, Genoa and Milan), and uses a GTAP-modelling approach developed by C40, Arup and the

Lymphovascular invasion is a dominant risk factor for lymph node metastasis in T2 rectal cancer

Background and study aims Surgical resection is standard treatment of T2 rectal cancer due to risk of concomitant lymph node metastases (LNM). Local resection could potentially be an alternative to surgical treatment in a subgroup of patients with low risk of LNM. The aim of this study was to identify clinical and histopathological risk factors of LNM in T2 rectal cancer. Patients and methods This

Glycated Albumin Percentage is Correlated With HbA1c : Theoretic Marker in Patients With Altered Erythrocyte Turnover

INTRODUCTION: The gold standard for monitoring long-term glucose levels in patients with diabetes mellitus is glycated hemoglobin (HbA1c). In conditions where the erythrocyte half-life is decreased, for example, in long-term kidney diseases and hemoglobinopathies, HbA1C may underestimate the long-term glucose exposure. Therefore, in these patient groups, other methods to monitor long-term glucose

Rituximab in multiple sclerosis - Fatigue, cognition, and efficacy

Background: Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. Fatigue and impaired information processing speed (IPS) are the most debilitating symptoms of MS. Natalizumab (NTZ) and rituximab (RTX), currently Sweden’s two most-prescribed drugs for MS treatment, are known to almost completely ameliorate clinical and radiological relapse activity

Through the Glass Door: Bridging the Identity-Reputation Gap via Crowdsourced Employee Ratings

Purpose: This paper investigates the impact of crowdsourced employee content, specifically from platforms like Glassdoor, on employer branding. It further suggests strategies for organisations to utilise this data to close the gap between their internal identity and external reputation. Building upon Urde & Greyser’s (2016) Corporate Brand Identity and Reputation Matrix (CBIRM), the study seek