Sökresultat

Filtyp

Din sökning på "*" gav 532425 sökträffar

Design for Desirability: An Innovation-Focused Research Collaboration between Academia and Industry

This paper outlines an innovation-focused design research collaboration that connects New Zealand design and manufacturing industry with advanced design thinking about design for desirability, a research area pursued at AFFECT - the Centre for Affective Design Research at Massey University in Wellington (NZ). Nowadays, it’s all about offering products that are desirable; products need to appeal to

Glutamate decarboxylase (GAD) autoantibody epitope shift during the first year of Type 1 diabetes

Autoantibodies in Type 1 diabetes patients may differentiate between glutamate decarboxylase (GAD65) cloned from human, mouse and rat with a significant better binding to the human antigen. A subgroup of 15% (27/183) patients showed significantly better binding to rodent than to human GAD65. The aim of this study was to determine whether the autoantibody specificity would remain anti-rodent during

Analysis of critical residues of HLA-DQ6 molecules in insulin-dependent diabetes mellitus

Among DQ6 molecules, DQA1(*)0102-DQB1(*)0602 is negatively associated with insulin-dependent diabetes mellitus (IDDM), but DQA1(*)0102-DQB1(*)0604 shows a neutral to positive association in Swedish children with IDDM. The aim of this study was to identify critical DQB1 residues that may account for the differences in IDDM association observed for these two DQ6 molecules. HLA-DQ genotyping in 425 I

Do You Recognise This Tea Flask? Transformation of brand-specific product identity through visual design cues

To create a recognisable and distinctive brand and product identity through design is a challenge for companies. What are the design elements through which users distinguish between products? What is the content of design that users employ to make this recognition? To explore this issue, a Master-level student design project was organised. In the project, design students first analysed the brand,

Relational Modes Between Industrial Design and Engineering Design – A Conceptual Model for Interdisciplinary Design Work

Focus on customer and market needs has initialized changes in product development work, which involve integration of industrial design and engineering design functions. Interdisciplinary teams are considered a prerequisite in order to achieve collaboration, and a necessity to meet market demands in new products. However, interdisciplinary teams are inherently associated with collaborative shortcom

Survey on Product Development Methods, Design Competencies, and Communication in Swedish Industry

This article presents the results of a questionnaire survey carried out during the spring of 2000. The results are based on the answers provided by a total of 99 respondents. Among other results the survey revealed that more than half of the responding companies have a formally documented strategy for product development work. Regarding disciplinary competencies, it is shown that design engineers

Theoretical uncertainties in exclusive electroproduction of S-wave heavy quarkonia

In this work, we revise the conventional description of J/ ψ(1 S) , Υ (1 S) , ψ′(2 S) and Υ ′(2 S) elastic photo- and electroproduction off a nucleon target within the color dipole picture and carefully study various sources of theoretical uncertainties in calculations of the corresponding electroproduction cross sections. For this purpose, we test the corresponding predictions using a bulk of ava

What makes an ally? Sweden and Finland as NATO’s closest partners

From 2013 onward, Sweden and Finland gradually distinguish themselves from all other NATO partners in order to meet the growing challenge how to defend the Baltics. In the analysis, the concept of ‘informal ally’, in contrast to ‘formal ally’, is introduced. A synthesized analytical framework is used to evaluate the process of ever closer partner cooperation and its shifting focus from cooperative

Neuropathy-related mutations alter the membrane binding properties of the human myelin protein P0 cytoplasmic tail

Schwann cells myelinate selected axons in the peripheral nervous system (PNS) and contribute to fast saltatory conduction via the formation of compact myelin, in which water is excluded from between tightly adhered lipid bilayers. Peripheral neuropathies, such as Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas syndrome (DSS), are incurable demyelinating conditions that result in pain, decrea

Endometrial cancer and oral contraceptives : an individual participant meta-analysis of 27 276 women with endometrial cancer from 36 epidemiological studies

BACKGROUND: Oral contraceptives are known to reduce the incidence rate of endometrial cancer, but it is uncertain how long this effect lasts after use ceases, or whether it is modified by other factors.METHODS: Individual participant datasets were sought from principal investigators and provided centrally for 27 276 women with endometrial cancer (cases) and 115 743 without endometrial cancer (cont

Volume flow assessment through simultaneous B-mode and Multigate Doppler

The typical approach for volumetric blood flow assessment consists of a velocity measurement performed in a single sample volume placed in the vessel centre, combined to an estimate of the average diameter. This simple approach produces large inaccuracies since it does not account for the complex flow configurations produced by complicated artery geometries and/or pulsatile conditions. Moreover, d