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Objective: To investigate the expression of Pyruvate dehydrogenase kinase 1(PDK1), phosphorylated Pyruvate dehydrogenase (p-PDH) and Pyruvate kinase isozyme type M2 (PKM2) based on Warburg effect pathway in cervical cancer tissues, and explore the roles of these molecules on prognosis and recurrence after postoperative radiation. Methods: The expressions of PDK1, p-PDH and PKM2 in primary tissues
BACKGROUND: Children, adolescents, and young adults with cancer (referred to as CAYAs) are at risk of long-term health complications, with cardiovascular disease (CVD) being a major concern. In addition, sociodemographic characteristics and traditional cardiovascular risk factors may also contribute to disparities in outcomes compared with those of the general population. The aim of this study was
Introduction Abdominal aortic aneurysm (AAA) mainly affects elderly men, grows slowly, and carries high mortality if left untreated, as rupture risk increases with larger diameters. AAA is well suited for screening due to its slow progression, long latent phase, reliable diagnostics, and established treatments. The primary aim of this thesis was to assess whether absolute infrarenal aortic diamete
At the fifth session of the United Nations (UN) Environment Assembly in March 2022, UN member states were mandated to negotiate an international, legally binding instrument on plastic pollution. This article assesses pre-session submissions from the second and third negotiation rounds to identify proposed measures and priorities for the treaty. The analysis, employing systematic qualitative conten
We study active human visuo-locomotive experience in everyday navigation from the viewpoints of environmental familiarity, embodied reorientation, and (sensorimotor) spatial update. Following a naturalistic, in situ, embodied multimodal behaviour analysis method, we conclude that familiar users rely on environmental cues as a navigation-aid and exhibit proactive decision-making, whereas unfamiliar
The temporality of global value chains is an important area of concern for economic geographers. This paper argues for the analytical value of closely examining the category of ‘turnover time’ as articulated in Marx’s work and subsequent historical-geographical materialism. We argue that turnover times of capitals in competition – hence struggles over time – can be conceptualised as a driving forc
Denna uppsats handlar om användning av artificiell intelligens i skol- och utbildningsmiljö, samt de potentiella utmaningar och hinder som finns för artikel 5(1)(a) AI förordningen, att försäkra uppfyllandet av barns rätt till tanke- och samvetsfrihet, i artikel 14 Barnkonventionen. De aktuella frågeställningarna i denna uppsats är: Hur försäkrar artikel 5(1)(a) AI förordningen uppfyllandet av baThis thesis investigates the use of AI within the educational environment, specifically the school environment, and the potential challenges and barriers for article 5(1)(a) AI Act, to ensure the realization of the children’s right to freedom of thought and conscience, under article 14 UNCRC. The research questions are: How does article 5(1)(a) AI Act ensure the realization of the children’s righ
Sammanfattning Denna studie undersöker hur olika åtgärder kan påverka trafiksäkerheten för oskyddade trafikanter vid cirkulationsplatser. Studien bygger på en analys av trafiksituationen på en cirkulationsplats i Helsingborg. Bedömningen av trafiksituationen genomfördes med hjälp av tre metoder: hastighetsmätningar med radarpistol, en konfliktanalys mellan olika trafikgrupper baserat på filmat maSummary This study examines how various measures can impact traffic safety for vulnerable road users at roundabouts. The study is based on an analysis of traffic conditions at a roundabout in Helsingborg. The assessment was conducted using three methods: speed measurements with a radar gun, a conflict analysis between different traffic groups based on recorded footage, and a summary analysis of S
Universities, operating at the intersection of state, market, and civil society, are increasingly called upon to address urgent global challenges, such as climate change, inequalities, and social injustice. This has given rise to hybrid roles for scholars, ranging from public intellectuals to policy advisers and academic entrepreneurs. Among these roles, scholar-activism stands out by explicitly a
Hjärtat består av fyra hålrum; två kammare och två förmak, som separeras av fyra hjärtklaffar. Dessa säkerställer att blodet enbart flödar åt ett håll och ger därmed hjärtat förutsättningarna för effektiv pumpning av blodet. Mitralisklaffen är en av dessa fyra hjärtklaffar och separerar vänster förmak från vänster kammare, vilket gör att den utsätts för det högsta trycket i hjärtat. För att mitralThe heart consists of four chambers, two atria and two ventricles, separated by four valves that ensure unidirectional blood flow and efficient cardiac function. Among these, the mitral valve regulates blood flow between the left atrium and left ventricle and is one of the most mechanically loaded structures in the heart, stabilized by the chordae tendineae, which are connective structures. Conseq
Precision-cut lung slices (PCLS) have gained increasing interest as a model to study lung biology and disease, as well as for screening novel therapeutics. In particular, PCLS derived from human tissue can better recapitulate some aspects of lung biology and disease as compared to PCLS derived from animals (e.g. clinical heterogeneity), but access to human tissue is limited. A number of different
Single cell sequencing technologies (scRNA-seq, scATAC-seq, etc.) have revolutionized the study of complex tissues and unique organisms, providing researchers with a much needed species agnostic tool to study biological processes at the cellular level. To date, scRNA-seq technologies are expensive, require sufficient cell quantities, and need biological replicates to avoid batch effects or artifac
This paper documents how the advent of the limited liability corporation contributed to the diffusion of steam technology during Sweden's industrialization. Using longitudinal establishment-level data, we show that incorporation sharply raised the probability that industrial establishments adopted steam. Incorporation facilitated technology adoption partly by enabling smaller establishments to exp
To study the mechanisms of relapse in KMT2A-rearranged (KMT2A-r) acute lymphoblastic (ALL) and acute myeloid leukemia (AML), we performed whole-genome and exome sequencing of infants and children with relapsed ALL/AML (n = 36), and longitudinal deep-sequencing of 257 samples in 30 patients. Somatic alterations in drug-response genes, most commonly in TP53 and IKZF1 (64%), were highly enriched in e
Background: Dementia is a global public health challenge, with Alzheimer's disease (AD) and vascular dementia (VaD) being the most prevalent subtypes. Air pollution is a potential risk factor for dementia, but few studies separate AD and VaD. Objective: This study aims to investigate whether exposure to air pollution is associated with the incidence of AD and VaD. Methods: This study involved 30,2
Sorption-enhanced steam reforming (SorESR) is an advanced thermochemical process integrating in-situ CO2 capture via solid sorbents to significantly enhance hydrogen production and purity. By coupling CO2 adsorption with steam reforming, SorESR shifts the reaction equilibrium toward increased H₂ yield, surpassing the limitations of conventional steam reforming (SR). The efficacy of SorESR critical
Purpose: A cancer diagnosis and treatment pose significant physical and psychological challenges. The study aimed to explore factors associated with distress over time in women diagnosed with breast cancer undergoing radiotherapy (RT) with access to a digital information tool, specifically examining if factors such as health literacy and self-efficacy had any influence on distress. Methods: In thi
