Sökresultat

Background: MicroRNA-379 (miR-379) has been reported to play a tumour-suppressing role in several cancer types. Our previous work demonstrated that miR-379 overexpression attenuates the metastatic spread of prostate cancer (PCa) both in vitro and in vivo. However, the underlying mechanisms remain poorly understood. Methods: To elucidate the mechanisms by which miR-379 affects metastases, we perf

Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor-specific mutations not only in protein-coding sequences but also in non-coding sequences. Although 98% of the genome is not translated into proteins, most studies have neglected the information hidden

Coleoid cephalopods (octopus, squid and cuttlefish) have unusually complex nervous systems. The coleoid nervous system is also the only one currently known to recode the majority of expressed proteins through A-to-I RNA editing. The deamination of adenosine by adenosine deaminase acting on RNA (ADAR) enzymes produces inosine, which is interpreted as guanosine during translation. If this occurs in

The coleoid cephalopods display unusually extensive mRNA recoding by adenosine deamination, yet the underlying mechanisms are not well understood. Because the adenosine deaminases that act on RNA (ADAR) enzymes catalyze this form of RNA editing, the structure and function of the cephalopod orthologs may provide clues. Recent genome sequencing projects have provided blueprints for the full compleme

Urban railway systems play an important role in creating sustainable cities, especially in megacities where they serve as the backbone of mass transit. Providing connection information for urban rail systems is essential to ensure continued use of public transport by passengers. However, metro systems can be operated by different service providers, creating challenges in connecting information whi

The purpose of this paper is to explore context adaptation of change processes in the setting of public administration. This is done by adopting a contingency approach. Thus, the research question guiding this study is: How is context adaptation enacted in change processes and what are the behavioural implications? Drawing on empirical findings from the Swedish Transport Administration, the study

Supply chain risk management (SCRM) is a common practice for most supply chains. It involves the processes of identifying, assessing, mitigating, and monitoring the risks of providing products and services within the supply chain. Many supply chains have prepared to deal with the uncertainties which may interrupt their supply chain operations. This research is interested to find the current SCRM p

In this work, we investigate the cryogenic performance of hafnia-based ferroelectric capacitors with and without an aluminum oxide (ALO) interlayer, comparing conventional metal-ferroelectric-metal (MFM) structures to metal-ferroelectric-insulator-metal (MFIM) counterparts. Devices employing Hf0.5Zr0.5O2 as the ferroelectric layer were characterized from 300 K down to 10 K, targeting temperature r

This article assesses the determinants of intragenerational social mobility across occupational trajectories in Southern Europe, focusing on Catalonia (1880s–1950s). Using a novel longitudinal database of individuals born 1870–1909 in the Baix Llobregat area, we examine sibling correlations in occupational status as a proxy for family socioeconomic resemblance and trace career progression across e

In the mid- to late 1970s, the Swedish economy faced a profit squeeze which threatened to hamper investments and the creation of jobs. This engendered a massive debate in the media and among economists and policymakers. This article investigates what I call ‘the politics of profits, the debates around the role of corporate profits in a democratic capitalist society and economy and the policy measu

The radioactive noble gas radon (222Rn) is a suitable tracer for atmospheric transport and mixing processes that can be used to evaluate and calibrate atmospheric transport models or to estimate greenhouse gas (GHG) emissions using the so-called radon tracer method (RTM). However, these applications require reliable estimates of the 222Rn fluxes from the soil. This study evaluates two process-base

The urgent need to address climate change and pollution prompts societies worldwide to adopt carbon neutral energy and electrification. To facilitate this, a range of technologies and policies will be needed. Alternatives to traditional power grid reinforcement, such as grid-enhancing technologies and system automation, are particularly attractive due to their potentially low cost and fast deploym

Metallic infrastructure, such as steel sheet situated within landfills, poses significant challenges to accurate tracking of leachate using induced polarization (IP) methods. The application of IP method is efficient to delineate leakage; however, the presence of metallic structures can cause an interference on the survey and generate high-chargeability anomalies as observed in field survey. To co

Lidar is a powerful technique normally associated with atmospheric monitoring. However, lidar techniques, also of the laser-induced fluorescence and laser-induced breakdown spectroscopy varieties, provide many new possibilities in unconventional fields including cultural heritage and ecological applications.

The Cherenkov Telescope Array Observatory (CTAO) is the next-generation ground-based gamma-ray observatory currently under construction. It will improve over the current generation of imaging atmospheric Cherenkov telescopes (IACTs) by a factor of five to ten in sensitivity and it will be able to observe the whole sky from a combination of two sites: a northern site in La Palma, Spain, and a south

While Ellis, Reid, and Kramer’s life history framework is convincing in explaining individual variation in life history strategies, it has certain limitations, which we discuss – drawing notably on the economic theory of fertility choice. In particular, we suggest that ambient cues to extrinsic mortality alone are not sufficient to trigger sustained net fertility decline.

Ung och skuldtyngd ger en djupgående inblick i upplevelsen av att som ung vuxen leva med skuldsättningsproblem - överskuldsättning - i dagens moderna konsumtions- och kreditsamhälle. Under två års tid har forskarna genom upprepade etnografiska intervjuer följt 18 personer mellan 18 och 25 år som är överskuldsatta. Resultaten besvarar frågor som: Hur kommer det sig att unga personer får problem med

The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, the European Innovation Council (EIC), in collaboration w

Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorly understood. Here, we investigated the relationship between cardiorespiratory fitness (CRF), epigenetic aging, and prom