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In liquid-liquid chromatography (LLC), components of a mixture are separated due to their different distribution between the phases of a biphasic liquid system composed of two or more solvents. In this work, for the first time, we combine a chromatography model with a liquid-liquid equilibria thermodynamic model to simulate the propagation of the solute and the solvents along the LLC column. The m
Objectives: Our aim was to compare direct costs for single pill combinations (SPCs) and free-drug combinations for hypertension treatment. Methods: We focused on Australia as a case study and reviewed total costs, and for the patient and government. We reviewed the Australian “Pharmaceutical Benefits Scheme item drug map” considering different thresholds for the government safety net. Total costs
Over the past decade, numerous assays for forensic age estimation based on the analysis of DNA methylation markers have been developed, demonstrating significant potential for use in criminal investigations. Despite these advancements, only few comprehensive evaluation studies were published. In this study, we present findings of an extensive inter-laboratory evaluation of the VISAGE Enhanced Tool
The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversia
The Industrial Symbiosis Readiness Level Matrix (ISRLM) tool presented in this paper, was developed to address the challenges inherent in implementing and managing Industrial Symbiosis (IS) networks. IS networks are complex systems involving diverse actors with varying levels of preparedness, perspectives, and priorities, which can result in miscommunication, inefficiencies, and slow implementatio
The random k-SAT model is one of the most important and well-studied distributions over k-SAT instances. It is closely connected to statistical physics and is a benchmark for satisfiability algorithms. We show that when k=Θ(log n) , any Cutting Planes refutation for random k-SAT requires exponential length in the regime where the number of clauses guarantees that the formula is unsatisfiable with
With the growing need to process large volumes of data, edge computing near data collection sources has become increasingly important. However, the resource constraints of edge devices require more efficient data processing techniques. Near-memory computing (NMC) presents an efficient solution, especially for data-intensive applications, by enabling processing that is both energy-efficient and har
ObjectiveTo evaluate if adding esketamine and clonidine has positive effects on postoperative pain, postoperative nausea and vomiting, and quality of recovery in patients who are at high risk for postoperative pain.DesignPatient- and assessor-blinded, superiority, randomised controlled trial.SettingSingle centre between 2022 and 2024.Patients125 adult patients, ASA I – II, planned for elective lap
Introduction: Depression and anxiety are leading contributors to the global burden of disease among women yet help-seeking for mental health concerns remains limited in lower-middle-income countries. This study aimed to estimate the prevalence of anxiety, depression, and help-seeking behaviors, and to identify factors associated with the absence of help-seeking among ever-married women of reproduc
We present the detection and characterisation of the TOI-1438 multi-planet system discovered by the Transiting Exoplanet Survey Satellite (TESS). To confirm the planetary nature of the candidates and determine their masses, we collected a series of followup observations including high-spectral resolution observations with HARPS-N and HIRES over a period of 5 years. Our combined modelling shows tha
Rationale, Aims and Objectives: Colonoscopy, though common, can be uncomfortable, necessitating routine assessment of patient experience per European guidelines. Positive patient experiences are crucial as they influence willingness for repeat procedures. Patient-reported experience measures (PREMs) effectively capture patient perspectives through surveys, empowering patients to influence healthca
In seven billion years, the Sun will be dead. As stars like the Sun pass from their present state to that of a dead white dwarf star, they undergo two phases of extremely high luminosity and radius—the red giant branch and the asymptotic giant branch—during which they will lose half or more of their mass. These changes to the star have a significant impact on orbiting planets, asteroids, and comet
Background: It is unclear whether thyroid hormone levels are associated with the risk of mortality, cardiovascular disease (CVD) events, or cancer in men with normal TSH. Objectives: We analyzed if serum free T4 (FT4) or TSH is associated with the risk of mortality, incident CVD events, or cancer in Swedish men. Methods: Elderly men (n = 1801; mean age 75 years) in the Gothenburg and Malmö subcoho
Background: Caffeine in doses above 400 mg, approximately four cups of coffee, induces panic attacks in 50% of individuals with panic disorder (PD) and elevates anxiety, but it is not known how individuals with PD respond to normally consumed doses or how caffeine interacts with emotional tasks. Aims: We hypothesized that 150 mg caffeine would increase subjective anxiety (primary outcome) as well
PURPOSE: Given the paucity of data regarding workplace risk of COVID-19, particularly from countries with limited lockdowns, we aimed to quantify the occupational risks of COVID-19-related hospital admission among workers in Sweden.METHODS: We identified 607,179 employed individuals, 20-69 years of age, in Skåne, Sweden. From December 31st, 2019-December 31st 2021, 2,633 incident COVID-19-related
Ultrasound optical tomography enables noninvasive characterization of tissue and lesions up to 5 cm below the skin surface, by enhancing diffuse optical tomography with ultrasound focusing resolution and an increased number of measurement points. For optimal clinical imaging, it is essential to be able to reconstruct tissue optical properties in real time during in vivo measurements, and therefore
This paper presents the first online, in-situ experimental evidence of the puffing behavior of aluminium (Al) atoms during the ignition of a micron-sized Al wire. As the protective alumina (Al2O3) layer ruptures, spatially resolved laser absorption measurements reveal the outward puffing of Al atoms from the molten Al wire core. These Al atoms then react with the surrounding oxidizers, leading to
