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An approach to helical tubular self-aggregation using C-2-symmetric self-complementary hydrogen-bonding cavity molecules

In an approach to helical self-aggregation, C-2-symmetric cavity compounds based on the fusion of the bicyclo[3.3.1] nonane and indole framework and incorporating two 2-pyridone hydrogen-bonding motifs, compounds (-)-4 (pyrrole N-butyl) and (-)-5 (pyrrole N-decyl), have been synthesized. The 2-pyridone AD-DA hydrogen-bonding motif failed to operate in the solid state as demonstrated by X-ray diffr

Broad-band photometric colors and effective temperature calibrations for late-type giants - I. Z=0.02

We present new synthetic broad-band photometric colors for late-type giants based on synthetic spectra calculated with the PHOENIX model atmosphere code. The grid covers effective temperatures T-eff = 3000... 5000 K, gravities log g = - 0.5... + 3.5, and metallicities [M/H] = + 0.5... - 4.0. We show that individual broad-band photometric colors are strongly affected by model parameters such as mol

Embodiment of consciousness

The present article is based on the premise that mind is an emergent property of the processes that produce consciousness. Any scientific understanding must necessarily consider the need of an explanation of consciousness. Instead, the non-sense property of traditional scientific modelling appears to hide the phenomenon. In contrast, the explored hypothesis is based on the assumption that the mean

Distribution and functional significance of phosphodiesterase isoenzymes in the human lower urinary tract

To date, it is widely accepted that several disorders of the male and female urogenital tract, such as erectile dysfunction, bladder overactivity, urinary stone disease and the benign prostatic syndrome, can be therapeutically approached by influencing the function of the smooth musculature of the respective organs. In order to achieve a pronounced drug effect without significant adverse events, e

Root colonisation by arbuscular mycorrhizal, fine endophytic and dark septate fungi across a pH gradient in acid beech forests

Colonisation by root endophytes can be beneficial to plants growing on acid, nutrient-poor soils. Arbuscular mycorrhizal (AM) fungi can supply herbs with nutrients and may give protection against aluminium toxicity. Two other root colonising fungi, fine endophytes (FE) and dark septate fungi (DSE), are less well known but are potentially of benefit to their host plant. AM fungi are the most preval

Prostate cancer screening decreases the absolute risk of being diagnosed with advanced prostate cancer - Results from a prospective, population-based randomized controlled trial

Objectives: Randomized controlled trials are currently conducted to assess whether the mortality from prostate cancer is reduced by early detection with the use of prostate-specific antigen (PSA) measurements in serum. To be effective, such a program should be able to reduce the absolute number of men diagnosed with metastatic prostate cancer (for which no cure is available). The aim of the presen

Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements

We investigated the relation between cobalamin deficiency, clinical changes and brain function in dementia patients. On admittance to the clinic, 24 patients had cobalamin deficiency, and dementia with additional symptoms of delirium. During cobalamin supplementation, the patients underwent repeated regional cerebral blood flow (rCBF) studies, psychiatric evaluations, and in some cases assessment

Stabilometry and one-leg hop test have high test-retest reliability

The purpose of this study was to investigate the reliability of repeated measurements and a possible learning or tiring process in single-limb stabilometry and one-leg hop test. An additional purpose was to study the correlation between different stabilometric variables. Seventy-five healthy subjects were examined twice with a median interval of 7 d, and with three consecutive measurements on each

Low Voltage CMOS Radio Receiver Front-End Design

The mass production of integrated circuits for digital electronics has made CMOS technology the most frequently used IC process today. Thanks to the large production volume, CMOS has increasingly become the most cost efficient technology of choice, and the fast development of small, high speed CMOS devices has made the technology feasible for many RF applications. However, as the transistor featur

Modulation of islet G-proteins, alpha-glucosidehydrolase inhibition and insulin release stimulated by various secretagogues

Guanine nucleotide-binding proteins (G-proteins) are known to act as important modulators of insulin release from the islets of Langerhans. We have recently found that the deoxynojirimycin-derivative emiglitate, a recognized inhibitor of intestinal alpha-glucosidehydrolase activity, is a powerful inhibitor of glucose-induced insulin release. With the use of isolated mouse islets the present invest

Conflict Prevention: Old Wine in New Bottles?

This essay examines the extent to which scholarly work offers new insights into the problematique of conflict prevention and whether there are any significant alterations in the international management of conflict. The existing literature generally exhibits a number of methodological and theoretical weaknesses, which makes conflict prevention less useful as an analytical concept. In practice, sta