Immunotherapy has largely failed in ovarian carcinoma (OC), likely due to that the vast tumor heterogeneity and variation in immune response have hampered clinical trial outcomes. Tumor-immune microenvironment (TIME) profiling may aid in stratification of OC tumors for guiding treatment selection. Here, we used Digital Spatial Profiling combined with image analysis to characterize regions of spati

A study of Bc+→χcπ+ decays is reported using proton-proton collision data, collected with the LHCb detector at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. The decay Bc+→χc2π+ is observed for the first time, with a significance exceeding seven standard deviations. The relative branching fraction with respect to the Bc+→J/ψπ+ decay is measured to

In nanoscale structures with rotational symmetry, such as quantum rings, the orbital motion of electrons combined with a spin-orbit interaction can produce a very strong and anisotropic Zeeman effect. Since symmetry is sensitive to electric fields, ring-like geometries provide an opportunity to manipulate magnetic properties over an exceptionally wide range. In this work, we show that it is possib

Machine Learning (ML) algorithms are generally designed for scenarios in which all data is stored in one data center, where the training is performed. However, in many applications, e.g., in the healthcare domain, the training data is distributed among several entities, e.g., different hospitals or patients’ mobile devices/sensors. At the same time, transferring the data to a central location for

Cortical sensory processing is greatly impacted by internally generated activity. But controlling for that activity is difficult since the thalamocortical network is a high-dimensional system with rapid state changes. Therefore, to unwind the cortical computational architecture there is a need for physiological ‘landmarks’ that can be used as frames of reference for computational state. Here we us

The resonant structure of the radiative decay Λb0→pK−γ in the region of proton-kaon invariant-mass up to 2.5 GeV/c2 is studied using proton-proton collision data recorded at centre-of-mass energies of 7, 8, and 13 TeV collected with the LHCb detector, corresponding to a total integrated luminosity of 9 fb−1. Results are given in terms of fit and interference fractions between the different compone

Laser-driven compact particle accelerators can provide ultrashort pulses of broadband X-rays, well suited for undertaking X-ray absorption spectroscopy measurements on a femtosecond timescale. Here the Extended X-ray Absorption Fine Structure (EXAFS) features of the K-edge of a copper sample have been observed over a 250 eV window in a single shot using a laser wakefield accelerator, providing inf

Background: Although the importance of quantitative SPECT has increased tremendously due to newly developed therapeutic radiopharmaceuticals, there are still no accreditation programs to harmonize SPECT imaging. Work is currently underway to develop an accreditation for quantitative 177Lu SPECT/CT. The aim of this study is to verify whether the positioning of the spheres within the phantom has an

En allmän översikt över handelns historia från stenåldern till idag, ämnad för gymnasieskolan.

The first measurements of femtoscopic correlations with the particle pair combinations π±KS0 in pp collisions at s=13 TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K0⁎(700) particle that has been considered a tetraquark candidate for over forty years. Source and final-state interacti

The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high transverse momentum (high pT) hadron trigger in proton-proton and central Pb-Pb collisions at sNN=5.02 TeV. A data-driven statistical method is used to mitigate the large uncorrelated background in central Pb-Pb collisions. Recoil jet distributions are reported for jet res

Charge-dependent two- and three-particle correlations measured in Xe–Xe collisions at sNN=5.44 TeV are presented. Results are obtained for charged particles in the pseudorapidity range |η|

This paper presents the data constituting the catalogue of animal bones from Iron Age settlements in Scania, as published in the book “Animal husbandry in Iron Age Scania, with a catalogue”, and part of the Sheep Ahoy project at Lund University. The dataset consists of osteological data from zooarchaeologically examined animal bone assemblages from Iron Age settlement sites in Scania. The data has

In a circular system, consumers need to acquire, use, look after and part with products in ways that recirculate or reuse materials and minimise waste. Thus, although seldom made explicit, consumer care is built into the circular economy project. In this article, we aim to contribute to the emerging body of sociological work on circular consumption by foregrounding the role of care in the performa

With care being increasingly present and offered for sale on markets consumers are more often asked to consider ethical questions. However, ethical consumption literature has not paid close attention to how the selling of different care offerings contributes to the ethicalisation of consumption. To illustrate and conceptualise this phenomenon, the present paper builds on an object-focused study of

Transition metal ions play crucial roles in the structure and function of numerous proteins, contributing to essential biological processes such as catalysis, electron transfer, and oxygen binding. However, accurately modeling the electronic structure and properties of metalloproteins poses significant challenges due to the complex nature of their electronic configurations and strong correlation e

Depression is common during pregnancy, and a considerable proportion of pregnant women take antidepressants. Modern antidepressants (e.g. SSRIs) are fairly safe to use during pregnancy. Several physiological changes occur in the pregnant state, possibly affecting the pharmacokinetics of many drugs. Metabolism via CYP enzymes are important for the elimination of antidepressants. This metabolism mayDepression is common during pregnancy, and a considerable proportion of pregnant women take antidepressants. Modern antidepressants (e.g. SSRIs) are fairly safe to use during pregnancy. Several physiological changes occur in the pregnant state, possibly affecting the pharmacokinetics of many drugs. Metabolism via CYP enzymes are important for the elimination of antidepressants. This metabolism may

Purpose: To investigate the change in zonisamide (ZNS) serum concentration and its consequences in pregnant women with epilepsy. Methods: Six hospitals in Norway and Denmark screened their records for women who had been using ZNS during pregnancy. Absolute serum concentrations as well as concentration/dose (CD)-ratios were compared to non-pregnant values. Descriptive data on seizure control and ob