Introduction: Alzheimer's disease (AD) is characterized by accumulation of amyloid beta (Aβ) and hyperphosphorylated tau (Tau-P) in the brain. Aβ enhances the activity of kinases involved in the formation of Tau-P. Phosphorylation at Thr 181 determines the propagation of multiple tau phosphorylations. Aβ is derived from the amyloid precursor protein (APP). Cleavage of APP by β-secretase also initi

This study evaluates the performance of five satellite precipitation products (GPM IMERG, TRMM 3B42, ERA5, PERSIANN, and CHIRPS) compared to monthly observations from two weather stations (Laayoune and Essmara) over 2001–2017 using statistical metrics including correlation coefficient (CC) and mean square error (MSE). The results reveal notable differences between products. On a monthly timescale,

Wind is a significant geomorphological agent in formerly glaciated areas and aeolian deposits surround and stretch across the Store Mosse (Great Bog) bog complex in southwestern Sweden. Both peat and aeolian sand are underlain by lacustrine sediment and the deposits record the area's transition from an initially ice-dammed lake to Ancient Lake Bolmen, which gradually drained, exposing sediments to

Brazil has faced severe droughts in recent decades, significantly affecting agriculture, water supply, and hydropower generation, among other sectors. The Paraná River Basin, a major hub for hydropower, has been particularly affected, posing challenges for water management. To address this, we conducted a study to provide tailored climate information for the Brazilian hydroelectric sector. Given t

Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth

Boken tar upp de allra yngsta familjehemsplacerade barnen – och deras psykiska mående och utveckling. Den utgår från djupintervjuer med familjehem och företrädare för familjehemsvården i flera svenska kommuner. Men den innehåller även en lättillgänglig översikt av senare års kunskapsutveckling om psykisk sårbarhet bland små placerade barn, och vad som enligt forskning är avgörande för att traumati

Explaining the maintenance of genetic variation in fitness-related traits within populations is a fundamental challenge in ecology and evolutionary biology. Frequency-dependent selection (FDS) is one mechanism that can maintain such variation, especially when selection favours rare variants (negative FDS). However, our general knowledge about the occurrence of FDS, its strength and direction remai

This paper presents the findings of 33 interviews, carried out in 2017, examining the factors influencing Palestinian refugees from Syria (PRS) in choosing Germany or Sweden as asylum destinations. The findings showed that there was a very high degree of destination specificity towards Sweden for nearly all of the participants. This was based on their desire to reach Sweden due to its accessible c

Mantle cell lymphoma (MCL) is dependent on a supportive tumor immune microenvironment (TIME) in which infiltration of CD163+ macrophages has a negative prognostic impact. This study explores how abundance and spatial localization of CD163+ cells are associated with the biology of MCL, using spatial multiomic investigations of tumor and infiltrating CD163+ and CD3+ cells. A total of 63 proteins wer

This paper explores the law and policy related to the identification, assessment, and recording of the statelessness of refugees in the Swedish asylum procedure. It considers the gaps in law and policy that can lead to a stateless refugee remaining in a prolonged, or potentially, indefinite stateless situation and the impacts of the temporary asylum law introduced in 2016. The temporary law can be

Group exhibition. Theme :The Strength of SleepCohabitations of the LivingThe Quebec City Biennial will draw its inspiration from the Canadian winter and the sleeping earth to focus on human sleep and the multiple nuances of the process of waking. Both sleep and the cold season are times of latency, transition, and pause, of suspended productivity, and of resistance against the exploitation of bodi

Group exhibition. Curated by Sandra Vieira Jürgens + Emília Tavares. MNAC and Coleção de Arta Contemporânea do Estado. MNAC, Lisbon, Portugal. 18 April - 23rd June, 2024. Included work: "Night for Day".

The manuscript focuses on an original method of preparation of metatitanic acid when only environmentally safe base substances are used in the synthesis process. The synthesis is based on the reaction of solid titanyl sulfate in an aqueous solution of sodium hydroxide. This method allows for (i) a full preservation of the morphology of the starting titanyl sulfate and (ii) a preparation of metatit

Background: Patients with heart failure have a greater risk of malnutrition and need an enhanced intake of nutrients. Purpose: The purpose of the study was to describe how patients admitted to a cardiac intensive care unit with heart failure, experience the intake of a protein-enriched ice cream, served as an in-between meal, and to explore this diet supplement's nutritional relevance in these pat

Atmospheric trace gas measurements can be used to independently assess national greenhouse gas inventories through inverse modeling. Atmospheric nitrous oxide (N2O) measurements made in the United Kingdom (UK) and Republic of Ireland are used to derive monthly N2O emissions for 2013–2022 using two different inverse methods. We find mean UK emissions of 90.5 ± 23.0 (1σ) and 111.7 ± 32.1 (1σ) Gg N2O

Each year, about 30% of all newly diagnosed cancer cases in women worldwide are breast cancers [1]. One of the most common techniques for breast cancer diagnosis is mammography. However, this technique provides limited functional information regarding breast tissue morphology. In cases of suspected malignancy invasive techniques such as biopsy are implemented.In this work an optical deep tissue im

Photoreceptor oil droplets (ODs) are spherical organelles placed most commonly within the inner segment of the cone photoreceptors. Comprising neutral lipids, ODs can be either non-pigmented or pigmented and have been considered optically functional in various studies. Among living amphibians, ODs were only reported to occur in frogs and toads (Anura), while they are absent in salamanders and caec

Dendrochronology traditionally involves invasive techniques that might harm cultural heritage artifacts. Non-invasive approaches using X-ray technology and computed tomography (CT) have emerged, but dedicated CT systems are limited in availability. This study explored the viability of using a recently developed photon counting medical CT scanner for growth ring analysis. Six wood samples from pine

Layered materials have attracted significant attention in recent years due to the diverse electronic properties arising from different structural variations. Here, we present angle-resolved photoemission spectroscopy measurements conducted on the topological material Sb4Te3. This material consists of a composite stacking of two distinct topological materials: the three-dimensional (3D) topological

We report on the luminescence properties of hydrothermally synthesized BaLuF5:Pr3+(1%) nanoparticles having a cubic crystal structure. The properties were investigated at low temperatures using time-integrated and time-resolved luminescence spectroscopy under VUV photon excitation in the energy range of 5–45 eV. This spectral region covers both the Pr3+ 4f2→4f15d1 transitions and the intrinsic abs