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Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer

Objective: Although targeted approaches have become available in second- and third-line settings, platinum-based chemotherapy remains the standard first-line treatment for advanced muscle-invasive bladder cancer (MIBC). Therefore, the prediction of platinum resistance is of utmost clinical importance. Methods: In this study, we established a routine compatible method for the molecular classificati

Transmogrification or Forvandling? : The Translations of Ovid’s Metamorphoses by Ted Hughes and Otto Steen Due

Within a decade appeared two appraised translations of the Latin poet Ovid's Metamorphoses: the English Tales from Ovid by Ted Hughes, and the Danish Ovids forvandlinger by Otto Steen Due. Though in general true to Ovid's text, the two translations are markedly different, reflecting different traditions and different aims. Whereas Hughes centres on stories and their symbolic value, Due is more ben

Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performance

Introduction: Plasma biomarkers will likely revolutionize the diagnostic work-up of Alzheimer's disease (AD) globally. Before widespread use, we need to determine if confounding factors affect the levels of these biomarkers, and their clinical utility. Methods: Participants with plasma and CSF biomarkers, creatinine, body mass index (BMI), and medical history data were included (BioFINDER-1: n = 7

Relation between perinatal outcome and gestational duration in term primiparous pregnancies stratified by body mass index

Introduction: There is growing evidence that induction of labor at 41 completed weeks improves neonatal outcome, at least among primiparous women. This study was performed to investigate whether maternal body mass index (BMI) should be considered when deciding on timing of intervention in term pregnancies. Material and methods: The study design was a historical cohort study using data from the Swe

Production Strategies of Vocal Attitudes

Humans have an impressive ability to communicate precise social intentions and desires with their voice - through vocal attitudes. Previous studies have shown how isolated acoustic features such as pitch can convey social attitudes, but have mostly worked with single attitudes and have not controlled for inter-speaker variability. Thus, the vocal behaviours used to produce social attitudes remain

Measurements of jet observables sensitive to b -quark fragmentation in t t ¯ events at the LHC with the ATLAS detector

Several observables sensitive to the fragmentation of b quarks into b hadrons are measured using 36 fb-1 of s=13 TeV proton-proton collision data collected with the ATLAS detector at the LHC. Jets containing b hadrons are obtained from a sample of dileptonic tt¯ events, and the associated set of charged-particle tracks is separated into those from the primary pp interaction vertex and those from t

Fluorescence-free quantitative measurements of nitric oxide and major species in an ammonia/air flame with Raman spectroscopy

Raman spectroscopy is a powerful technique that allows for simultaneous measurements of multiple species; however, it suffers from low signal intensity and, in diagnostics of ammonia (NH3) combustion, strong flame fluorescence. The current work re-introduces a multipass setup to perform enhanced quantitative Raman spectroscopy measurements of major species and nitric oxide (NO) in a premixed lamin

Exclusion of Disperse Orange 3 is possible from the textile dye mix present in the Swedish baseline patch test series. A study by the Swedish Contact Dermatitis Research Group

Background: The textile dye mix (TDM) 6.6% in petrolatum contains Disperse Blue (DB) 35, Disperse Yellow 3, Disperse Orange (DO) 1 and 3, Disperse Red 1 and 17, and DB 106 and 124. The most frequent allergen in TDM-positive patients is DO 3. Around 85% of para-phenylenediamine (PPD)-allergic dermatitis patients have been positive to DO 3. There has been a discussion to exclude DO 3 from TDM 6.6% b

Strongly reduced optical absorption efficiency of soot with addition of potassium chloride in sooting premixed flames

Optical properties of soot have been investigated with and without potassium chloride (KCl) salt added to the soot formation process in a premixed ethylene/air flame. A strong decrease in optical absorption efficiency of the soot was observed with increasing amounts of KCl added to the fuel based on the method of fluence curve analysis using laser-induced incandescence (LII). To understand the rea

The Helsinki Convention’s agricultural nutrient governance: how domestic institutions matter

National policy styles and path-dependencies are affecting the abilities of Baltic Sea countries to deliver on their commitments under the Helsinki Convention. This article synthesizes evidence and insights from studies relating to the provisions on agricultural nutrient management, a main source of marine pollution. We contend that governments that are strongly concentrated vertically, while frag

The effect of eco-certification on demand: The case of MSC-certified Norway lobster

We investigate if Marine Stewardship Council (MSC) certified Norway lobster fishing vessels in Sweden got higher prices and sold larger quantities after certification was introduced in 2015. Using detailed daily panel data and exploiting the fact that the same fishing water contains both certified and non-certified vessels, we use a difference-in-difference model for analysing demand effects of MS

Unravelling the origin of the common wall lizards (Podarcis muralis) in south-eastern Europe using mitochondrial evidence

The origin of the common wall lizards (Podarcis muralis) populations in south-eastern Europe (namely in Bulgaria and Romania), representing the north-eastern range border of this species, was addressed using mitochondrial DNA. We compared cytochrome b sequences from Bulgaria and Romania with those from the contiguous range in Central Europe that are available from previous studies. We recorded fiv

Conservative random walk*

Recently, in [11], the “coin-turning walk” was introduced on Z. It is a non-Markovian process where the steps form a (possibly) time-inhomogeneous Markov chain. In this article, we follow up the investigation by introducing analogous processes in Zd, d ≥ 2: at time n the direction of the process is “updated” with probability pn; otherwise the next step repeats the previous one. We study some of th