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Background: Moderate-to-severe hemophilia B is treated with lifelong, continuous coagulation factor IX replacement to prevent bleeding. Gene therapy for hemophilia B aims to establish sustained factor IX activity, thereby protecting against bleeding without burdensome factor IX replacement. Methods: In this open-label, phase 3 study, after a lead-in period (≥6 months) of factor IX prophylaxis, we
The ecological effects of mass-flowering crops on pollinator abundance and species richness of neighbouring habitats are well established, yet the potential evolutionary consequences remain unclear. We studied effects of proximity to a mass-flowering crop on the pollination of local co-flowering plants and on patterns of natural selection on a pollination-generalised plant on the Tibetan Plateau.
Background: Community-based day centres (DC) in Sweden provide support to people with severe mental health problems. The role of DC motivation for outcomes in terms of occupational engagement and personal recovery is yet unknown. Aims: To compare two groups who received DC services, one of which also received the 16-week Balancing Everyday Life (BEL) intervention. The focus was motivation for DC s
The aim was to explore existential loneliness in different long-term care contexts as narrated by older people. A qualitative secondary analysis was performed of 22 interviews with older people in residential care, home care, and specialized palliative care. The analysis started with naive reading of interviews from each care context. As these readings showed similarity with Eriksson’s theory of t
Objectives: In Sweden, pneumococcal serotype distribution in adults with community-acquired pneumonia (CAP) and potential coverage of currently licensed pneumococcal conjugate vaccines (PCVs) is unknown. Methods: During 2016–2018, patients aged ≥18 years hospitalized with radiologically confirmed (RAD+) CAP were enrolled at Skåne University Hospital in a study on the etiology of CAP in Sweden (ECA
Dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. HoweDynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) MRI is an emerging imaging technique that provides a molecular-specific type of image contrast, based on magnetic labelling of exchangeable protons. The technique enables the use of biodegradable sugars as contrast agents, and such compounds are believed to have less side effects than conventional MRI contrast agents. Howe
Following his acclaimed earlier study on mediumship and survival, Alan Gauld providesa more complete account of about 50 years of early studies on mediumship with a select group ofmediums (e.g., Mrs. Piper, Mrs. Leonard, Mrs. Dowden). He describes in detail why many if not mostof the criticisms against extraordinarily accurate accounts by these mediums do not hold waterwhen analyzed in detail. Gau
There is limited theoretically informed research on sustainability in the space tourism market. An extended model of goal-directed behaviour (EMGB) is created and verified with individual and organizational interventions, comparing space tourism experienced and non-experienced travellers. Results revealed that individual intervention has fully significant effects on all MGB constructs, while organ
The demand for an increased number of antennas at base stations is driving research on decentralized processing schemes aimed at reducing the information volume that has to be transferred to, and processed at, a central processing unit (CPU). Some of these schemes can reduce the dimensions of the data while achieving information-lossless processing with respect to centralized architectures. Howeve
Covid-19 increased the social and economic vulnerability of island societies. Swedish islands are key tourism destinations but are also home to many island residents. Previous studies have high-lighted the impact of Covid-19 on core areas, but our knowledge of its impact on island communities is lac-king. We use phenomenology to analyse how communities in small Swedish islands perceive the impact
Impulsive noise is one of the most challenging forms of interference in an underwater acoustic environment. In this paper, we present an underwater acoustic channel deconvolution method based on a sparse representation framework. The application of the method enables a channel impulse response reconstruction that is robust to impulsive noise. By exploiting the inherent structure in the channel res
BackgroundPrevious research has emphasized the high prevalence and far-reaching consequences of violations of ethical principles in patient care.AimTo study the extent of violations perceived by healthcare professionals in Swedish adult psychiatric care.MethodsOnline survey among 2,538 mental health professionals. A revised version of Transgressions of Ethical Principles in Health Care Questionnai
I denna avhandling studeras en särskild kategori av subharmoniska funktioner, det vill säga reellvärda funktioner vars värde i en specifik punkt är mindre än eller lika med funktionens medelvärde på sfärer med centrum i punkten. Sådana funktioner återfinns på flera håll i vetenskapen. Ett exempel är temperaturen i ett bord efter att en värmeslinga slagits på längs bordets rand. I detta fall kommerWe study the Perron–Bremermann envelope P(μ, φ):=sup{u(z) ; u ∈ PSH(Ω), (ddcu)n≥ μ, u^* ≤ φ} on a B-regular domain Ω. Such envelopes occupy a central position within pluripotential theory as they, for suitable μ and φ harmonic and continuous on the closure of Ω, constitute unique solutions to the Dirichlet problem for the complex Monge–Ampère operator. Much is also known about the measures that gu
Despite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is <50%. While most high-risk neuroblastoma patients initially respond to treatment, often with complete clinical remission, many eventually relapse with therapy-resistant tumors. Novel therapeutic alternatives that prevent the recurrence of therapy-resistant tumors are urgently needed. To u
