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MUC4 Is a Sensitive and Extremely Useful Marker for Sclerosing Epithelioid Fibrosarcoma: Association With FUS Gene Rearrangement.

Sclerosing epithelioid fibrosarcoma (SEF) is a rare aggressive fibroblastic neoplasm composed of cords of epithelioid cells embedded in a dense collagenous stroma. The reported immunophenotype of SEF is nonspecific. Some SEF cases show morphologic and molecular overlap with low-grade fibromyxoid sarcoma (LGFMS), suggesting a relationship between these tumor types. MUC4 has recently been identified

Determinants of distribution and prevalence of avian malaria in blue tit populations across Europe: separating host and parasite effects.

Although avian malarial parasites are globally distributed, the factors that affect the geographical distribution and local prevalence of different parasite lineages across host populations or species are still poorly understood. Based on the intense screening of avian malarial parasites in nine European blue tit populations, we studied whether distribution ranges as well as local adaptation, host

Flocked nasal swab versus nasopharyngeal aspirate in adult emergency room patients: similar multiplex PCR respiratory pathogen results and patient discomfort.

Fifty adult emergency room patients with symptoms of respiratory tract infections or acute onset of extreme fatigue were sampled by both nasopharyngeal aspirate (NPA) and flocked nasal swab (fNS). Respiratory agents were detected by a qualitative influenza PCR and an 18-valent multiplex PCR in 20 of 29 patients with a clinical diagnosis of respiratory tract infection, and in 3 of 21 without such a

Literary Celebrity Reconsidered

The ongoing celebritisation of society not only comprises ‘celebrity sectors’ such as entertainment and sports, but also literature. As in other cultural fields, the commodities to be sold – books – are marketed using the ‘personalities’ directly connected to them by authors appearing on television shows or being selected for feature articles. The aim of the article is to point out limitations to

Palaeokarst evidence for widespread regression and subaerial exposure in the middle Katian (Upper Ordovician) of Baltoscandia: significance for global climate.

We report on widespread and contemporary palaeokarst in the middle Katian (Upper Ordovician) of Sweden, Estonia and Latvia, the first major palaeokarst horizon to be reported from the Ordovician of Baltoscandia. The solution features occurwithin a fewmetres of thick zone of limestone immediately belowthe widespread Fjäcka Shale and are related to an unconformity with preserved palaeorelief in the

Enhanced airway smooth muscle cell thromboxane receptor signaling via activation of JNK MAPK and extracellular calcium influx.

Thromboxane is a key inflammatory mediator and potent airway constrictor. It acts on thromboxane A(2) (TP) receptors and contributes to airway inflammation and airway hyperresponsiveness that is the characteristic feature of asthma. The present study was designed to study TP receptor signaling in airway smooth muscle cells by using an organ culture model and a set of selective pharmacological inhi

High zooplankton diversity in the extreme environments of the McMurdo Dry Valley lakes, Antarctica

The McMurdo Dry Valley lakes of Antarctica constitute some of the harshest and most isolated freshwater environments on Earth which might be expected to limit the biogeographical expansion of many organisms. Despite this, we found that the biodiversity of rotifer zooplankton is the highest ever recorded on the Antarctic mainland. We identified in total nine rotifer taxa, of which six are new to th

Characterizing the geometry of InAs nanowires using mirror electron microscopy

Mirror electron microscopy (MEM) imaging of InAs nanowires is a non-destructive electron microscopy technique where the electrons are reflected via an applied electric field before they reach the specimen surface. However strong caustic features are observed that can be non-intuitive and difficult to relate to nanowire geometry and composition. Utilizing caustic imaging theory we can understand an

Nighttime lights and population changes in Europe 1992–2012

Nighttime satellite photographs of Earth reveal the location of lighting and provide a unique view of the extent of human settlement. Nighttime lights have been shown to correlate with economic development and population but little research has been done on the link between nighttime lights and population change over time. We explore whether population decline is coupled with decline in lighted ar

Does one community shape the other? Dragonflies and fish in Swedish lakes

1. Freshwater communities are often structured by predation. In permanent lentic freshwater habitats dragonfly larvae are major predators which, in return, suffer predation by fish. Antipredator traits vary between the dragonfly species, and the dragonfly communities are therefore shaped by the presence of fish. But fish communities vary, and as different fish species affect dragonflies in differe

Rapid X-ray photoreduction of dimetal-oxygen cofactors in ribonucleotide reductase.

Prototypic dinuclear metal cofactors with varying metallation constitute a class of O2-activating catalysts in numerous enzymes such as ribonucleotide reductase (RNR1). Reliable structures are required to unravel the reaction mechanisms. However, protein crystallography data may be compromised by X-ray photoreduction (XPR). We studied XPR of Fe(III)Fe(III) and Mn(III)Fe(III) sites in the R2 subuni

Measurement of chi(c1) and chi(c2) production with root s=7 TeV pp collisions at ATLAS

The prompt and non-prompt production cross-sections for the chi(c1) and chi(c2) charmonium states are measured in pp collisions at root s = 7TeV with the ATLAS detector at the LHC using 4.5 fb(-1) of integrated luminosity. The chi(c) states are reconstructed through the radiative decay chi c -> J/psi gamma ( with J/psi -> mu(+)mu(-)) where photons are reconstructed from gamma -> e(+)e(-) conversio

Full-scale in-line hydrolysis and simulation for potential energy and resource savings in activated sludge – a case study

The potential effects of altering primary settlers during biological in-line hydrolysis and converting a nitrifying activated sludge process into a partial pre-denitrification process for the purpose of resource conservation were evaluated. A full-scale primary sludge hydrolysis experiment was performed at a wastewater treatment plant and implemented in a dynamic modelling tool based on ASM2d. The

Transparently Wrap-Gated Semiconductor Nanowire Arrays For Studies Of Gate-Controlled Photoluminescence

We present a technique to measure gate-controlled photoluminescence (PL) on arrays of semiconductor nanowire (NW) capacitors using a transparent film of Indium-Tin-Oxide (ITO) wrapping around the nanowires as the gate electrode. By tuning the wrap-gate voltage, it is possible to increase the PL peak intensity of an array of undoped InP NWs by more than an order of magnitude. The fine structure of

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults

Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to in