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Seminal progastricsin

Lundquist and Seedorff [1] demonstrated the presence of a zymogen in human seminal fluid, that could be activated into an active enzyme by acidification to pH 2. As the enzyme was purified, it became evident that it was in fact equivalent to the minor gastric enzyme originally named as progastricsin (EC 3.4.23.3) [2–6].This report provides a short review on the similarities and differences between

Episodic memory formation in unrestricted viewing

The brain systems of episodic memory and oculomotor control are tightly linked, suggesting a crucial role of eye movements in memory. But little is known about the neural mechanisms of memory formation across eye movements in unrestricted viewing behavior. Here, we leverage simultaneous eye tracking and EEG recording to examine episodic memory formation in free viewing. Participants memorized mult

Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role in pathogenesis is often poorly understood. Gene editing and in vivo imaging approaches will help to identify the molecular and functional role of these targets and the consequence of their regional dysfunction on the whole-brain level. We combine CRISPR-Cas9

Capturing writers’ typing while visually attending the emerging text : a methodological approach

Knowledge about writers’ eye movements and their effects on the writing process, and its product – the finally edited text—is still limited. Previous research has demonstrated that there are differences between reading texts written by someone else and reading one’s own emerging text and that writers frequently look back into their own texts. (Torrance, Johansson, et al., 2016). For handwriting, A

Experimental evidence that group size generates divergent benefits of cooperative breeding for male and female ostriches

Cooperative breeding allows the costs of parental care to be shared, but as groups become larger, such benefits often decline as competition increases and group cohesion breaks down. The counteracting forces of cooperation and competition are predicted to select for an optimal group size, but variation in groups is ubiquitous across cooperative breeding animals. Here, we experimentally test if gro

Characterizing the initial conditions of heavy-ion collisions at the LHC with mean transverse momentum and anisotropic flow correlations

Correlations between mean transverse momentum [pT] and anisotropic flow coefficients v2 or v3 are measured as a function of centrality in Pb–Pb and Xe–Xe collisions at sNN=5.02 TeV and 5.44 TeV, respectively, with ALICE. In addition, the recently proposed higher-order correlation between [pT], v2, and v3 is measured for the first time, which shows an anticorrelation for the presented centrality ra

The desert-governess romance : Regency England meets exotic Arabia

In this article we discuss how two types of popular romances – the desert romance and the governess romance – have blended into what we refer to as the desert-governess romance. In the world of romance, the governess and the sheikh may be an odd couple but they do make good bedfellows. Etymologically speaking, the governess (“A woman who holds or exercises authority” (OED)) is the perfect love matIn this article we discuss how two types of popular romances – the desert romance and the governess romance – have blended into what we refer to as the desert-governess romance. In the world of romance, the governess and the sheikh may be an odd couple but they do make good bedfellows. Etymologically speaking, the governess (“A woman who holds or exercises authority” (OED)) is the perfect love mat

High-energy and ultra-high-energy neutrinos: A Snowmass white paper

Astrophysical neutrinos are excellent probes of astroparticle physics and high-energy physics. With energies far beyond solar, supernovae, atmospheric, and accelerator neutrinos, high-energy and ultra-high-energy neutrinos probe fundamental physics from the TeV scale to the EeV scale and beyond. They are sensitive to physics both within and beyond the Standard Model through their production mechan

Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments

Background: In ultra-rare sarcomas (URS) the conduction of prospective, randomized trials is challenging. Data from retrospective observational studies (ROS) may represent the best evidence available. ROS implicit limitations led to poor acceptance by the scientific community and regulatory authorities. In this context, an expert panel from the Connective Tissue Oncology Society (CTOS), agreed on

DN Debatt: Klimatlagen kräver att regeringen ändrar politik

Nästa år ska regeringen enligt klimatlagen presentera en handlingsplan för hur Sverige ska nå klimatmålen. Minst ett dussin myndigheter har bidragit med underlag. Men inte ens om samtliga förslag i dessa rapporter genomförs kommer det att räcka för att fylla det gap som har uppstått med den nya regeringens politik, skriver Klimatpolitiska rådet.

Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk

Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adoptin

An environmental justice perspective on ecosystem services

Mainstreaming of ecosystem service approaches has been proposed as one path toward sustainable development. Meanwhile, critics of ecosystem services question if the approach can account for the multiple values of ecosystems to diverse groups of people, or for aspects of inter- and intra-generational justice. In particular, an ecosystem service approach often overlooks power dimensions and capabili

Extracting structural motifs from pair distribution function data of nanostructures using explainable machine learning

Characterization of material structure with X-ray or neutron scattering using e.g. Pair Distribution Function (PDF) analysis most often rely on refining a structure model against an experimental dataset. However, identifying a suitable model is often a bottleneck. Recently, automated approaches have made it possible to test thousands of models for each dataset, but these methods are computationall

Risk Assessment of Outdoor Background Gamma Radiation at Duhok City, in Kurdistan Region, Iraq

In this study, a model „ADM606M Portable Multifunction Ratemeter /Scalar“ (Gamma GP110 Detector) was used to estimate the effective dose rate in (µSv.h-1). The data were analyzed for three specified hours per day (9:00 a.m., 11:00 a.m., and 1:00 p.m.) from January 2009 to June 2016. In July 2019, the gamma scout radiation meter (dosimeter) was used to measure the outdoor gamma effective dose rate

A qualitative study of the long-term consequences and adaptation in daily life after replantation surgery at a young age

Introduction: Impaired functioning is seen in patients following replantation surgery to the thumb or fingers. Our aim was to explore long-term consequences and adaptation in daily life after a thumb and/or multiple finger amputation followed by replantation surgery during young age. Methods: Semi-structured interviews were conducted with nine recruited individuals and analysed using content analy