Objectives:We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease.Methods:We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebr

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously

Background: Although uncomplicated cystitis is often self-limiting, most such patients will be prescribed antibiotic treatment. We are investigating whether treatment of cystitis with an NSAID is as effective as an antibiotic in achieving symptomatic resolution. Methods/Design: This is a randomized, controlled, double blind trial following the principles of Good Clinical Practice. Women between th

Although Disordered Eating Behaviors (DEB) is an ill-defined concept, multiple studies have examined prevalence of DEB and its relations to other variables in various populations. DEB have been shown to predict more serious eating disorders which in turn can lead to death. Mostly girls seem to suffer from DEB, but the question has been raised whether this, at least, partially is due to the methods

This paper treats the feasibility to use only the sign bit of the in-phase and quadrature components when estimating time and frequency in OFDM systems. Using only the sign bit is shown to result in a frequency dependent bias, which can be easily compensated. The approach is evaluated for LTE and DVB-H, where the estimation is performed using the cyclic prefix, and for WLAN 802.11g, where the estim

Secretory leukocyte protease inhibitor (SLPI) is a protein with anti-protease and antimicrobial properties that is constitutively secreted from the airway epithelium. The importance of maintaining a balance between proteases and anti-proteases, and robust innate defence mechanisms in the airways, is exemplified by inflammatory lung conditions such as chronic obstructive pulmonary disease (COPD) an

A fully three-dimensional anisotropic elastic model for vascular tissue modelling is here presented. The underlying strain energy density function is assumed to additively decouple into volumetric and deviatoric contributions. A straightforward isotropic neo-Hooke-type law is used to model the deviatoric response of the ground substance, whereas a micro-structurally or rather micro-sphere-based ap

Tubular ceramic membranes with many, small-diameter feed flow channels have the advantage of being less costly per unit membrane area. For this reason, membranes with many small channels are often favored over those with fewer larger channels. We have theoretically studied how the diameter of the feed flow channels influences the frictional pressure drop, the membrane performance (flux and retenti

Two conceptual tools in historical analyses of environmental issues and political ecologies have gained much attention in recent years: ecologically unequal exchange and landesque capital. The former narrows in on how societal relations of power allow for the physical transfer of environmental degradation—upon which our daily consumption rests—to places far away from our environmentally clean (and

BACKGROUND: The high prevalence of obesity in children and adolescents emphasizes the necessity to develop evidence-based treatment programs that are useful in a clinical setting. AIMS: The overall aim of the thesis was to develop and evaluate multidisciplinary approaches for management of children and adolescents with obesity. The focus was on generalizability of the treatment in a clinical setti

The intensity-calibrated spectra of W II have been recorded in the spectral interval 23 000-51 300 cm(-1) (1950-4350 angstrom), using the FT500 UV Fourier Transform Spectrometer at Lund Observatory. Combining the intensity data in this work with lifetimes previously measured using the time-resolved laser-induced-fluorescence (TR-LIF) technique resulted in transition probabilities and log gf values

The aim of this study is to examine how the church of Dalby was perceived and interpreted symbolically in the early Middle Ages. During this time the abbey of Dalby was a major ecclesiastical centre in Scania. In the 12th century the original basilica underwent a grand rebuilding in Romanesque style, resulting in a much greater church with a larger chancel and a monumental westwork with a crypt-li

Guangdong Province in China runs a risk of gradually increasing pollution of its agricultural land as a consequence of toxic agricultural products. We concentrate here on the situation for cadmium, copper and lead. For these metals we describe the toxicology, the current pollution and its sources, and what can be done to improve the situation by cleaning the soil from pollutants, by choice of crop

In order to compare the two species’ flight performance over the exposed and windy Falsterbo Peninsula, where thermal conditions seldomly are very favorable, we used tracking radar to study flight parameters of sparrowhawks Accipiter nisus and common buzzards Buteo buteo during autumn migration. The results showed a clear difference between sparrowhawks and common buzzards in their flight altitude

Many migratory bird species fly mainly during the night (nocturnal migrants), others during daytime (diurnal migrants) and still others during both night and day. Need to forage during the day, atmospheric structure, predator avoidance and orientation conditions have been proposed as explanations for the widespread occurrence of nocturnal migration. However, the general principles that determine t

Background and purpose - Epidemiological studies of full-thickness rotator cuff tears (FTRCTs) have mainly investigated degenerative lesions. We estimated the population-based incidence of acute FTRCT using a new diagnostic model. Patients and methods - During the period November 2010 through October 2012, we prospectively studied all patients aged 18-75 years with acute onset of pain after should