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Evaluating the accuracy and precision of a two-compartment Kärger model using Monte Carlo simulations.

Specific parameters of the neuronal tissue microstructure, such as axonal diameters, membrane permeability and intracellular water fractions are assessable using diffusion MRI. These parameters are commonly estimated using analytical models, which may introduce bias in the estimated parameters due to the approximations made when deriving the models. As an alternative to using analytical models, a

Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes

Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic control that raises the need for effective therapy targeted at the underlying defects in

The Lund-Malmo creatinine-based glomerular filtration rate prediction equation for adults also performs well in children

Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one inc

Disagreement of feminine gender: historical perspectives

In this paper a particular case of grammatical gender agreement system is discussed, concerning the referent of young females or small children. These referents are grammatically treated as neuter nouns, disregarding their biological sex. This is termed gender disagreement. It is argued here that this is due to the older classification of nouns based on active and inactive distinction, stemming fr

Construction of Minimum Euclidean Distance MIMO Precoders and Their Lattice Classifications

This correspondence deals with the construction of minimum Euclidean distance precoders for multiple-input multiple-output (MIMO) systems with up to four transmit antennas. By making use of a state-of-the-art technique for optimization over the unitary group, we can numerically optimize the MIMO precoders. The correspondence then proceeds by identifying the obtained precoders as well-known lattice

Long-term follow-up after risk-adapted treatment in clinical stage 1 (CS1) nonseminomatous germ-cell testicular cancer (NSGCT) implementing adjuvant CVB chemotherapy. A SWENOTECA study

Background: To offer minimized risk-adapted adjuvant treatment on a community and nationwide basis for patients with clinical stage 1 (CS1) nonseminomatous germ-cell testicular cancer (NSGCT). The aim was to reduce the risk of relapse and thereby reducing the need of later salvage chemotherapy while maintaining a high cure rate. Patients and methods: From July 1995 to January 1998, a total of 232

The transportability of multisystemic therapy to Sweden: Short-term results from a randomized trial of conduct-disordered youths

This randomized clinical trial assessed the effectiveness of multisystemic therapy (MST) for 156 youths who met the diagnostic criteria for conduct disorder. Sweden's 3 largest cities and I small town served as the recruiting area for the study. A mixed factorial design was used, with random allocation between MST and treatment as usual groups. Assessments were conducted at intake and 7 months aft

Calpain is involved in C-terminal truncation of human aggrecan

Mature aggrecan is generally C-terminally truncated at several sites in the CS (chondroitin sulfate) region. Aggrecanases and MMPs (matrix metalloproteinases) have been suggested to be responsible for this digestion. To identify whether calpain, a common intracellular protease, has a specific role in the proteolysis of aggrecan we developed neoepitope antibodies (anti-PGVA, anti-GDLS and anti-EDLS

Hormonal and immune profiles in blood were unaffected by PHA provocation in suckling and weaning pigs

The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocatio

Altered movement patterns and deviating muscular activity in individuals with anterior cruciate ligament injury

Popular Abstract in Swedish Skador i knäleden är vanligt förekommande och främre korsbandsskada drabbar i Sverige årligen mer än 8 per 10 000 personer i åldern 10-64 år. Följderna av skadan kan bli bestående funktionsnedsättning med bl.a. instabilitet, plötsliga och smärtsamma knäledsvikningar och ökad risk för nya skador. Cirka hälften av patienterna utvecklar ledsvikt (artros) 10-15 år efter denThe purpose of this thesis was to increase the understanding of altered movement patterns in individuals with anterior cruciate ligament (ACL) injury in order to improve ACL rehabilitation, and to develop an observational instrument termed Test for Substitution Patterns (TSP) for standardized, quantifiable scoring of altered movement patterns in legs and trunk. In all, 142 participants, 93 with A

Searches for heavy long-lived sleptons and R-hadrons with the ATLAS detector in pp collisions at root s=7 TeV

A search for long-lived particles is performed using a data sample of 4.7 fb(-1) from proton-proton collisions at a centre-of-mass energy. root s = 7 TeV collected by the ATLAS detector at the LHC. No excess is observed above the estimated background and lower limits, at 95% confidence level, are set on the mass of the long-lived particles in different scenarios, based on their possible interactio

A "wait and learn" strategy of postural control learning in children?

This study compares the children and adult response to a novel postural challenge. One group of children (n = 13, age 7-9) and one adult reference group (n = 12 age 15-32) were subjected to vibration induced body sway and posturography with both open and closed eyes for 5 consecutive days. There was a gradual decrease of induced body sway over time in both groups (p < 0.001) between the subsequent

Development of a system for determination of the C-13/C-12 isotopic ratio with high spatial resolution

Stable carbon isotopes play an important role in the interpretation of biological activity, particularly when the fossil record is studied. In combination with morphological and chemical data, isotopic information can be useful in paleontology and astrobiology. In this paper the development of a microanalytical ion beam system for the measurement of the carbon isotope ratio with high spatial resol

Analysis-by-synthesis speech coding with quantization noise modeling

Iii analysis-by-synthesis linear predictive coding (AbS-LPC) an LPC synthesis filter is combined with an analysis-by-synthesis search of the excitation signal. The synthesis filter is an estimator for the speech signal given the excitation. However in most AbS-LPC algorithms this estimator has no explicit model of the quantization noise, which is present in the excitation signal. This paper descri

Chips on wafers, or packing rectangles into grids

A set of rectangles S is said to be gridpacked if there exists a rectangular grid (not necessarily regular) such that every rectangle lies in the grid and there is at most one rectangle of S in each cell. The area of a grid packing is the area of a minimal bounding box that contains all the rectangles in the grid packing. We present an approximation algorithm that given a set S of rectangles and a