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SFPQ-ABL1-positive B-cell precursor acute lymphoblastic leukemias

In recent years, a subgroup of B-cell precursor acute lymphoblastic leukemia (BCP ALL) without an established abnormality ("B-other") has been shown to be characterized by rearrangements of ABL1, ABL2, CSF1R, or PDGFRB (a.k.a. ABL-class genes). Using FISH with probes for these genes, we screened 55 pediatric and 50 adult B-other cases. Three (6%) of the adult but none of the childhood B-other caseIn recent years, a subgroup of B‐cell precursor acute lymphoblastic leukemia (BCP ALL) without an established abnormality (“B‐other”) has been shown to be characterized by rearrangements of ABL1 , ABL2 , CSF1R , or PDGFRB (a.k.a. ABL‐class genes). Using FISH with probes for these genes, we screened 55 pediatric and 50 adult B‐other cases. Three (6%) of the adult but none of the childhood B‐other c

Serological testing in small vessel vasculitis

Serological analysis has a central role in the diagnostic work-up of patients with suspected small vessel vasculitis, both for establishing a specific diagnosis and for the monitoring of response to therapy. Autoantibodies can be detected in all forms of primary small vessel vasculitis as well as in the most common forms of secondary vasculitis. For primary vasculitis the most important serologica

Wafer-scale nanofabrication of sub-100 nm arrays by deep-UV displacement Talbot lithography

In this manuscript, we demonstrate the potential of replacing the standard bottom anti-reflective coating (BARC) with a polymethylglutarimide (PMGI) layer for wafer-scale nanofabrication by means of deep-UV displacement talbot lithography (DTL). PMGI is functioning as a developable non-UV sensitive bottom anti-reflective coating (DBARC). After introducing the fabrication process using a standard B

Multisensoriska sinnesrum i Sverige : - resultatet av en enkätundersökning inom ramen för det nordisk-baltiska SPEDUCULT-projektet

Inom det nordisk-baltiska projektet SPEDUCULT skickades det ut en enkät till personer och verksamheter som arbetar med multisensoriska miljöer/sinnesrum i Sverige. De som svarade arbetade huvudsakligen inom verksamheter för personer med intellektuell funktionsnedsättning, såsom särskilda centra för sinnesstimulering, daglig verksamhet, habilitering eller skola. Svaren kom från 27 olika orter i SveWithin the Nordic-Baltic SPEDUCULT project, a survey was sent to people and work places engaged in multisensory environments (also called MSEs or sensory rooms) in Sweden. Most of the respondents worked with individuals with intellectual disabilities, at centra for sensory stimulation, workplaces for daily activities, habilitation centra or schools. The answers to the survey came from 27 places in

An update on the epidemiology of ANCA-associated vasculitis

ANCA-associated vasculitis (AAV) includes granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. Epidemiological studies in AAV are important in understanding possible aetiologic mechanisms and facilitating healthcare planning. However, epidemiological studies present a number of challenges including clear definition of cases differentiated fr

Postcompression of picosecond pulses into the few-cycle regime

In this work,we demonstrate postcompression of 1.2 ps laser pulses to 13 fs via gas-based multipass spectral broadening. Our results yield a single-stage compression factor of about 40 at 200 W in-burst average power and a total compression factor >90 at reduced power. The employed scheme represents a route toward compact few-cycle sources driven by industrial-grade Yb:YAG lasers at high average p

Modeling to Predict Factor VIII Levels Associated with Zero Bleeds in Patients with Severe Hemophilia A Initiated on Tertiary Prophylaxis

Background: Factor VIII (FVIII) trough levels > 1 IU/dL in patients with severe hemophilia A receiving regular prophylaxis may optimize bleed protection. Objectives: In this post hoc analysis of patients receiving tertiary prophylaxis for approximately 1 year, the relationship between estimated FVIII levels and reported bleeds was investigated to predict the potential for zero bleeds. Methods: Six

Vertical transmission of a nematode from female lizards to the brains of their offspring

Parasites have evolved a diversity of lifestyles that exploit the biology of their hosts. Some nematodes that parasitize mammals pass via the placenta or milk from one host to another. Similar cases of vertical transmission have never been reported in avian and nonavian reptiles, suggesting that egg laying may constrain the means of parasite transmission. However, here we report the first incidenc

Subjective and Objective Characteristics of Patients Seen at a Psychodermatology Unit : One-year Experience in Malmö, Sweden

Clinical epidemiological knowledge concerning psychodermatology patients is scarce. The objective of this study was to assess morbidity in a new psychodermatology service. Information was gathered from patient records at the psychodermatology unit in Skåne University Hospital, Malmö, Sweden, from 1 February 2017 to 31 January 2018. All patients were screened with the Hospital Anxiety and Depressio

A Posthuman Data Subject? The Right to Be Forgotten and Beyond

The general assumption in the West is that there still is an inherent difference between persons and things. This divide informs how “the human” and human subjectivity are constructed as distinct from all others. Recently, the distinction has been challenged in posthumanist theory, where it has been argued that the divide between human and nonhuman agents—or rather, bodies—is always an effect of a

The semantic content of gestures varies with information status, definiteness and clause structure

When speakers mention referents for the first time in discourse, they can also accompany them with gestures. This study explores whether the semantic content expressed by such gestures – whether gestures focus on the entity itself or on an action that the referent is involved in – is related to discourse properties. We consider the potential effects of a referent’s information status (brand-new/in