Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct and downstream treatment effects linked to disease modification. Recent results from clinical trials of anti–amyloid β (Aβ) treatments have raised the question of how to best characterize the relationship between AD biomarkers and clinical endpoints.

Inte sällan beskrivs byggbranschen som konservativ och motvillig till förändringar, både av folk i branschen, av forskare samt av folk i allmänhet. Likväl har byggbranschen under årens lopp genomgått ett antal förändringar, ofta som reaktioner på nya förutsättningar skapade av förändringar i det omgivande samhället. Den här artikeln redovisar hur ett antal projektledare i stora byggprojekt uppfatt

We document the socioeconomics of wind power expansion in Sweden using two metrics. First, we compute the difference in socioeconomic status (SES) between residents exposed to wind power (0-2 km from the closest turbine) and those not exposed. For each site, the metric is computed ten years prior until five years after construction. When the comparison group is other residents within the same muniWe document the socioeconomics of wind power expansion in Sweden using two metrics. First, we compute the difference in socioeconomic status (SES) between residents exposed to wind power (0-2 km from the closest turbine) and those not exposed. For each site, the metric is computed ten years prior until five years after construction. When the comparison group is other residents within the same muni

Flera stora byggprojekt pågår och planeras i Sverige, varav flera är skattefinansierade. Det ligger därför i både samhällets och byggbranschens parters intresse att utveckla kunskapen kring hur stora byggprojekt organiseras och leds, aktat de många samhällsförändringar som Sverige genomgått de senaste decennierna. Denna studie har följaktligen studerat hur olika samhällsförändringar påverkat förut

We show that a profinite group, in which the centralisers of non-trivial elements are metabelian, is either virtually pro-p or virtually soluble of derived length at most 4. We furthermore show that a prosoluble group, in which the centralisers of non-trivial elements are soluble of bounded derived length, is either soluble or virtually pro-p.

Generic statements play a crucial role in concept learning, communication and education. Despite many efforts, the semantics of generics remain a controversial issue, as they do not seem to fit our standard theories of meaning. In this article, we attempt to shed light on this problem by focusing on how these sentences function in reasoning. Drawing on a distinction between property and diagnostic

Inequality is ubiquitous in time and space. It is often measured simply as differences in incomes between various groups, but the phenomenon is more complex than so. Inequality is a many-faceted phenomenon that manifests itself in a number of ways. It shows up in a variety of contexts, for example gender, age, origin, ethnicity, disability, sexual orientation, class, religion and place. The presen

Traditional methods for measuring chemical exposure have challenges in terms of obtaining sufficient data; therefore, improved methods for better assessing occupational exposure are needed. One possible approach to mitigate these challenges is to use self-monitoring methods such as sensors, diaries, or biomarkers. In the present study, a self-monitored method for measuring soot exposure, which inc

Objective To elicit expert opinion and gain consensus on specific exercise intervention parameters to minimise hip bone mineral density (BMD) loss following traumatic lower limb amputation. Methods In three Delphi rounds, statements were presented to a panel of 13 experts from six countries. Experts were identified through publications or clinical expertise. Round 1 involved participants rating th

För samverkansforumet Intelligent Intelligence, baserat på Lunds universitet, lämnades en rapport om de viktigaste forskningsresultaten från deltagande i International Association för Intelligence Educators årliga europeiska konferens.

We study stochastic interaction network models whereby a finite population of agents, identified with the nodes of a graph, update their states in response to pairwise interactions with their neighbors as well as spontaneous mutations. These include the main epidemic models, such as the Susceptible-Infected -Susceptible, the Susceptible-Infected-Recovered, and the Susceptible-Infected-Recovered-Su

Background Impulse control disorders (ICDs) are known psychiatric conditions in Parkinson’s disease (PD), especially as a side effect of antiparkinsonian therapy. Screening for vulnerable patients and avoiding high-risk treatments can be an effective approach to reduce the ICD burden in patients with PD. Thus, our goal was to identify risk factors for ICDs in PD in the Swedish total population. Me

We study perturbations of non-recurrent parameters in the exponential family. It is shown that the set of such parameters has Lebesgue measure zero. This particularly implies that the set of escaping parameters has Lebesgue measure zero, which complements a result of Qiu from 1994. Moreover, we show that non-recurrent parameters can be approximated by hyperbolic ones.

Objectives While Mycoplasma genitalium is reported as a common rectal infection among men who have sex with men (MSM), published data refer predominantly to urethral infections. Currently, most guidelines recommend M. genitalium testing from urine in men with symptomatic, non-gonococcal urethritis. Macrolide resistance-associated mutations (MRMs) among M. genitalium have increased during the last

This chapter reviews polarization vision in diverse crustaceans with a specific focus on work completed since the 2014 edition of this book. Almost all crustaceans are sensitive to the planar polarization of light. They commonly possess two channels of orthogonally arranged photoreceptors with intrinsically polarization-sensitive ordered microvilli. These two channels are compared to impart linear