OBJECTIVES: Chronic lung allograft dysfunction including Bronchiolitis obliterans syndrome (BOS) is common after lung transplantation. Histologically, BOS is recognized as fibrotic lesions with accumulated extracellular matrix (ECM) in small airways. Lung fibroblasts are major producers of ECM and vascular endothelial growth factor (VEGF). In this study we hypothesize that VEGF is involved in BOS

BACKGROUND: Preschool children with autism in southern Sweden participated in a comprehensive Naturalistic Developmental Behavioral Intervention (NDBI) program. AIMS: To evaluate the ongoing NDBI program by comparing the pre- and postintervention outcomes in terms of improved autism symptom severity. METHOD: The improvement of Autism Diagnostic Observation Schedule (ADOS-R) test results between ba

Background: Mental illness is one of the fastest rising threats to public health, of which depression and anxiety disorders are increasing the most. Research shows that diet is associated with depressive symptoms or depression (depression). Aim: This study aimed to investigate the diets impact on depression, by reviewing the scientific evidence for prevention and treatment interventions. Method: A

Nature-based adaptation planning is a challenging endeavor, not least because it requires transdisciplinary approaches to unite different actors' efforts and capacities. However, empirical knowledge on associated governance processes is scarce and fragmented. Against this background, this paper examines the integration of nature-based approaches for climate change adaptation into municipalities’ d

Promoting resource- and energy-efficient home lighting through technology and behaviour change requires an understanding of how residents currently use lighting and what they want from it. However, users’ needs and desires relating to lighting in homes are poorly understood, as research is still limited. This paper aims to provide a fuller picture of residents’ experiences with their homelighting.Promoting resource- and energy-efficient home lighting through technology and behaviour change requires an understanding of how residents currently use lighting and what they want from it. However, users' needs and desires relating to lighting in homes are poorly understood, as research is still limited. This paper aims to provide a fuller picture of residents' experiences with their home lighting

BACKGROUND: At birth, infants' lungs are fluid-filled. For newborns to have a successful transition, this fluid must be replaced by air to enable gas exchange. Some infants are judged to have inadequate breathing at birth and are resuscitated with positive pressure ventilation (PPV). Giving prolonged (sustained) inflations at the start of PPV may help clear lung fluid and establish gas volume with

Although diagnostic criteria have been developed characterizing postural orthostatic tachycardia syndrome (POTS), no single set of criteria is universally accepted. Furthermore, there are gaps in the present criteria to identify individuals who have this condition. The reproducibility of the physiological findings, the relationship of symptoms to physiological findings, the presence of symptoms al

Growing seal populations are examples of successful marine management, and the seals are often seen as a symbol of a thriving ecosystem. However, seals are well known to interact with local small-scale fisheries by feeding from the gears. This causes both lost catches and broken gear, which negatively affect the economic viability of the small-scale fisheries. While lost catches are known to be su

In this study, a two-dimensional model including the governing equations of mass, momentum, species, energy and charge, is developed and then applied to investigate the performance and multiphysics transport processes of solid oxide fuel cells with counter-flow arrangement. The current density and power density are calculated and presented, and the distributions of species and temperature are also

Background: Guidelines recommend considering workload in interpretation of the systolic blood pressure (SBP) response to exercise, but reference values are lacking. Design: This was a retrospective, consecutive cohort study. Methods: From 12,976 subjects aged 18–85 years who performed a bicycle ergometer exercise test at one centre in Sweden during the years 2005–2016, we excluded those with preva

In addition to a rise in mean air and water temperatures, more frequent and intense extreme climate events (such as heat waves) have been recorded around the globe during the past decades. These environmental changes are projected to intensify further in the future, and we still know little about how they will affect ecological processes driving harmful cyanobacterial bloom formation. Therefore, w

When all citizens vote, the influence of radical parties decreases. Despite this being a central justification for compulsory voting in the past, it has been absent from contemporary debates. I examine the normative and empirical premises of the ‘moderation thesis’ in relation to radical right-wing populist parties today and suggest that, under certain conditions, compulsory voting can limit these

Pharmacological interventions that combine pro-anabolic and anti-catabolic drugs to treat recalcitrant fractures have shown remarkable efficacy in augmenting the regenerative response. Specifically, in rodent models of fracture repair, treatment with BMP-7 and Zoledronate (ZA) has almost uniformally resulted in complete union. However, delayed remodeling may be problematic for ZA-treated fractures

Social trust is linked to both public sector size and to economic growth, thereby helping to explain how some countries combine high taxes with high levels of economic growth. This paper examines if social trust insulates countries against the negative effects of public sector size on growth, documented in several studies. We note that the effect is theoretically ambiguous. In panel data from 66 c

In many financial applications, it is important to classify time-series data without any latency while maintaining persistence in the identified states. The authors propose a greedy online classifier that contemporaneously determines which hidden state a new observation belongs to without the need to parse historical observations and without compromising persistence. Their classifier is based on tIn many financial applications, it is important to classify time-series data without any latency while maintaining persistence in the identified states. The authors propose a greedy online classifier that contemporaneously determines which hidden state a new observation belongs to without the need to parse historical observations and without compromising persistence. Their classifier is based on t

The K̄NN bound system, symbolically denoted as "K-pp", is the simplest K̄-nuclear bound system which has been widely discussed as a consequence of the strongly attractive K̄N interaction in I = 0 channels. Many theoretical works have pointed out the existence of the "K-pp" bound system, but the calculated properties such as the binding energy and the width spread out due to the uncertainty of the

We study how star formation is regulated in low-mass field dwarf galaxies (⁠105≤M⋆≤106M⊙⁠), using cosmological high-resolution (⁠3pc⁠) hydrodynamical simulations. Cosmic reionization quenches star formation in all our simulated dwarfs, but three galaxies with final dynamical masses of 3×109M⊙ are subsequently able to replenish their interstellar medium by slowly accreting gas. Two of these galaxie

Bone marrow edema (BME) is one of the most common findings on magnetic resonance imaging (MRI) after an ankle injury but can be present even without a history of trauma. This article will provide a systematic overview of the most common disorders in the ankle and foot associated with BME. The presence of BME is an unspecific but sensitive sign of primary pathology and may act as a guide to correct