Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored. Full-length wild-type TM complementary DNA (cDNA) was incorporated into vector pcDNA6 for transfection into COS-7 cells for transient expression. Mutagenesis was performed to create 7 TM mutants with nat

Size distribution measurements performed at five different stations have been investigated during a one-year period between 01 June 2000 and 31 May 2001 with focus on diurnal, seasonal and geographical differences of size distribution properties. The stations involved cover a large geographical area ranging from the Finnish Lapland (67degrees N) down to southern Sweden (56degrees N) in the order V

We investigate the surface-enhanced Raman scattering (SERS) of rhodamine 6G (R6G) adsorbed on Au nanoparticles attached to InP nanowires. We find that nanowire arrays act as frameworks for effective SERS substrates with a significantly higher Raman signal sensitivity than a planar framework of Au nanoparticles adsorbed two-dimensionally on a flat surface. The SERS signal displays a clear polarizat

Background and Methods: Inhaled insulin has recently emerged as an alternative to subcutaneous insulin administration. One inhaled insulin device, AERx (R) (a registered trademark of Aradigm Corp., Hayward, CA, or its affiliates in the United States and other countries) insulin diabetes management system (iDMS) (Novo Nordisk A/S, Bagsvoerd, Denmark), uses a unique liquid human insulin strip to del

Our previous studies have indicated that the IgG-binding M-family proteins (IgGBP) of group A streptococci may be involved in eliciting experimental acute poststreptococcal glomerulonephritis (APSGN) in the rabbit. These surface proteins were also found to trigger production of anti-IgG, which might conceivably act to enhance renal deposition of immune complexes (IC). In the present study, a clini

The aim of this study was to evaluate the efficacy of the new optimised levoclopa, Stalevo(R) (levoclopa, carbidopa and entacapone) in patients with Parkinson's disease experiencing end-of-close wearing-off. Treatment with Stalevo was compared to treatment with traditional immediate-release levodopa and dopa-decarboxylase inhibitor (DDCl) formulations along with adjunct entacapone (Comtess(R)/Comt

The clinical diagnosis Of Multiple system atrophy (MSA) is fraught with difficulty and there are no pathognomonic features to discriminate the parkinsonian variant (MSA-P) from Parkinson's disease (PD). Besides the poor response to levodopa, and the additional presence of pyramidal or cerebellar signs (ataxia) or autonomic failure as major diagnostic criteria, certain other clinical features known

The article describes the history of edge-wear research from 1838 to 1978.

Various types of graph statistics for graphs and digraphs are presented as numerators of incomplete U-statistics, with symmetric and asymmetric kernels, respectively. Thus, asymptotic Poisson limits of these statistics are provided by using limit theorems for the sums of dissociated random variables. Several applications to statistical analysis of graphs are given

The objective of this benchmarking is to establish a comparison of several tools and processes used in thermal NIL with Si stamps at the nanoscale among the authors' laboratories. The Si stamps have large arrays of 50 nm dense lines and were imprinted in all these laboratories in a similar to 100 nm thick mr-18010E film. Other materials, such as mr-17010E, were also tested. Good patterns were obta

Mammalian polyamine carriers have not yet been molecularly identified. The fluoroprobe Spd-C2-BODIPY faithfully reports polyamine transport and accumulates almost exclusively in polyamine-sequestering vesicles (PSVs). Polyamines might thus be imported first by a plasma membrane carrier and then sequestered into pre-existing PSVs (model A), or be directly captured by polyamine receptors undergoing

In this study the elasto-plastic constitutive equations are reformulated using the assumption of constant strain rate direction within a load increment. This assumption allows the constitutive evolution laws to be rewritten as ordinary differential equations (ODEs). The set of ODEs is reduced using the Krieg and Krieg description of the deviatoric stress space. Although this approach does generall

We demonstrate a method for growth of GaP nanocrystals on Si(001), developed to avoid defects related to antiphase domain boundaries in the proximity of the GaP/Si interface. The technique is based on sub-mum-sized selective-area epitaxy of GaP on atomically flat Si in masked openings. We have used field-emission scanning electron microscopy together with transmission electron microscopy to illust

The aim of this study is to analyse the spatial variability of meso-scale precipitation in Scania and to assess the influence of synoptic scale atmospheric circulation. The modes of spatial variation are revealed by EOF analysis of monthly precipitation totals between 1963 and 1990, which were obtained from a dense rain-gauge network in Scania. southern Sweden. The influence of local physiography

The electroenzymatic reactions of Trametes hirsuta laccase in the pure organic solvent dimethyl sulfoxide (DMSO) have been investigated within the framework for potential use as a catalytic reaction scheme for oxygen reduction. The bioelectrochemical characteristics of laccase were investigated in two different ways: (i) by studying the electroreduction of oxygen in anhydrous DMSO via a direct ele

Object Shift in Swedish is restricted to unstressed pronouns. Sentences where an object pronoun precedes a sentence adverb, such as Han åt den inte ‘(lit.) He ate it not’, are thus well-formed, whereas sentences with a full noun phrase (NP) object preceding a sentence adverb, such as Han åt sylt/sylten inte ‘(lit.) He ate jam/the jam not’, are ill-formed. The neural correlates to violation of this

Beech bark lesions, (Cryptococcus fagisuga), the most common lichen and fungi epiphytes on beech (Fagus sylvatica) stems were studied at 48 sites in Scania, south Sweden. Different site variables and the influence of nitrogen deposition were investigated. The field vegetation and lichens were used as biological indicators by calculating indices for nutrition status, toxicity, pH, light and moistur