We consider two main maximal operators measuring smoothness. For all possible values of the parameters, we give simple examples of bounded compactly supported functions that show quite clearly the difference between these maximal operators. Bibliography: 3 titles.

Kraven på försvagad konflikt­rätt hotar Sveriges välfungerande lönebildning och riskerar att öka arbetslivs­kriminaliteten. I förlängningen väntar ingrepp från politiker och från EU.

In the face of the triple planetary crisis, which includes climate change, biodiversity loss and environmental degradation, there is growing recognition that the environment needs to be re-evaluated and better protected. Recent developments, such as a values assessment by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES),1 the concept of biocultural right

This chapter considers the creation of the Later Life Audio and Radio Co-operative (LLARC) as an outcome of a participatory action research (PAR) project with a focus on facilitating later life civic participation. Developed in the UK, but with potential to become a global initiative, the LLARC is a collaborative network of older content creators, age-friendly radio stations, third-sector organisa

Cardiometabolic diseases are the leading preventable causes of death in most geographies. The causes, clinical presentations, and pathogenesis of cardiometabolic diseases vary greatly worldwide, as do the resources and strategies needed to prevent and treat them. Therefore, there is no single solution and health care should be optimised, if not to the individual (ie, personalised health care), the

Social trust is a moral resource with a normatively highly desirable pay-off. Previous research argues that universal welfare state programmes ‘make’ social trust whereas means-testing programmes ‘break’ it. Despite its important implications for welfare-state design, comparative longitudinal evidence for this hypothesis is scarce. To test whether within-country changes in social trust are associa

States in neutron-rich s-d shell nuclei were populated in the reaction of a 14C beam at Elab = 22 MeV on a 14C target. Coincidences between γ rays and either other γ rays or light charged particles were measured. γ rays in coincidence with protons established levels at 66.8, 1730, 1823, and 2219 keV in 27Na. The states are compared with calculations based on the s-d shell model and the cranked Nil

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD patients as Lewy bodies. While it is not entirely clear which alpha-synuclein protein species is diseas

This paper extends the application of quantile-based Bayesian inference to probability distributions defined in terms of quantiles of observable quantities. Quantile-parameterized distributions are characterized by high shape flexibility and parameter interpretability, making them useful for eliciting information about observables. To encode uncertainty in the quantiles elicited from experts, we p

Free heme is released from hemoproteins during hemolysis or ischemia reperfusion injury and can be pro-inflammatory. Most studies on nephrotoxicity of hemolysis-derived proteins focus on free hemoglobin (fHb) with heme as a prosthetic group. Measurement of heme in its free, non-protein bound, form is challenging and not commonly used in clinical routine diagnostics. In contrast to fHb, the role of

Background: District Heating (DH) is a technology that provides heating and domestic hot water to buildings and is an important technology for supporting the European energy transition. As such the heating systems increasingly resort to renewable heat sources and waste heat, it is even more important that they operate in the most efficient way possible. DH companies have access to the primary netw

There is a serious imbalance between parking demand and capacity in cities due to limitations in their parking facilities. It is important for drivers to know about parking vacancies before their trips. Meanwhile, administrators need information about parking capacity and demand before a week begins to improve parking management. A method is proposed here for predicting parking demand and capacity

This review summarises the presentations during a workshop session entitled “The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis – Mechanistic Concepts and Clinical Implications” at the International Continence Society (ICS) 2021 Melbourne Virtual meeting. Benign prostatic hyperplasia (BPH) is a highly prevalent condition that can result

Tara gum (TG) is a polysaccharide extracted from the seeds of a South American tree called Tara (Caesalpinia spinosa). TG is a galactomannan with many applications in the food industry, mainly as an emulsifier and stabilizer agent. In addition, it is also used in the paper and cosmetic industries. In the present study, we performed a molecular characterization based on chemical composition and phy

BACKGROUND: Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeut

Background: The use of remote services such as video consultations (VCs) has increased significantly in the wake of the COVID-19 pandemic. In Sweden, private healthcare providers offering VCs have grown substantially since 2016 and have been controversial. Few studies have focused on physicians’ experiences providing care in this context. Our aim was to study physicians’ experiences of VCs, focusi

Analysis of microbial data from archaeological samples is a growing field with great potential for understanding ancient environments, lifestyles, and diseases. However, high error rates have been a challenge in ancient metagenomics, and the availability of computational frameworks that meet the demands of the field is limited. Here, we propose aMeta, an accurate metagenomic profiling workflow for

Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We investigated the role of interferon regulatory fa