PurposeThis study aimed to characterize the Swedish cohort of surgically treated patients with TSC and explore differences in preoperative investigation and outcome over time.MethodsData on patient and seizure characteristics were retrieved from the Swedish National Epilepsy Surgery Register. Two-year follow-up results were compared between the years 1997–2010 and 2011–2018. Preoperative investiga

Sibling sexual abuse constitutes a substantial proportion of sexual abuse committed by young people. The consequences for victims of sibling abuse have been found as extensive as the consequences of abuse from adults. Sibling sexual abuse also affects the entire family. However, little research has investigated sibling sexual abuse and its consequences from a parents’ perspective. This study exami

Social and economic change in the built environment is increasingly driven by processes of datafication. These often find expression through smart phone apps and private platforms that seek to upset the status quo by mediating consumer and producer interactions, and by monetising the data these produce. This paper uses the practice-oriented concept of ‘disruptive data’ to draw attention away from

The Monte-Carlo simulated response for γ-ray detection of the FAst TIMing Array (FATIMA) for exploitation within the DEcay SPECtroscopy (DESPEC) experimental system at the FAIR Phase-0 facility at Darmstadt, Germany is presented. In this configuration, FATIMA consisted of 36 LaBr3(Ce) detectors surrounding the AIDA, position-sensitive charged-particle active stopper. The decay of the Iπ=8+ isomer-

Alkaline ion-solvating membranes derived from a tetrazole functionalized poly(arylene alkylene) are prepared, characterized and evaluated as electrode separators in alkaline water electrolysis. The base polymer, poly[[1,1′-biphenyl]-4,4′-diyl(1,1,1-trifluoropropan-2-yl)], is synthesized by superacid catalyzed polyhydroxyalkylation and subsequently functionalized with tetrazole pendants. After equi

Abstract in ArmenianԳ­րա­կա­նա­գէտ Հա­րոլդ Պլում յայտ­նած է, թէ մարդ պէտք է ըլ­լայ «կոյր, խուլ եւ համր չհասկ­նա­լու հա­մար, որ Շէյքս­փի­րի հո­յա­կապ, երկ­­դի­մի Վե­նե­տի­կի Վա­ճա­ռա­կա­նը… խո­րա­պէս հա­կա­սե­մա­կան գործ մըն է»։ Նման կար­ծիք­ներ ընդ­հան­րա­ցած են նաեւ ակա­դե­մա­կան աշ­խար­հէն դուրս։ Օ­թել­լոյի եւ Ան­սանձ Կնոջ Սան­ձա­հար­ումին հետ, Վե­նե­տի­կի Վա­ճա­ռա­կա­նը ան­հանգս­տու­թեան մատ­նո

This article gives a brief account of the two-hundred-year-old performance history of Hamlet at Elsinore Castle; this is followed by a discussion of Gertrude as portrayed in nine English or English-speaking Hamlets at Elsinore, beginning with Olivier and the Old Vic in 1937 and concluding with Cape Town Theatre Company eighty-five years later, in 2022. The article discusses different aspects of ho

Lilli Zickerman (1858–1949) was an entrepreneur who took part in organising the Swedish handicraft associations in the late 19th century. She was also a pioneer in the archives and active in the feminine sphere of textile handicraft. From 1914–1931 she conducted a huge inventory called Swedish Folk Textile Art that consists of more than 24,000 photographs and descriptions of vernacular textiles an

Cycling provides numerous benefits to individuals and to society but the burden of road traffic injuries and fatalities is disproportionately sustained by cyclists. Without awareness of the contributory factors of cyclist death and injury, the capability to implement context-specific and appropriate measures is severely limited. In this paper, we investigated the effects of the characteristics rel

The high pulse intensity and repetition rate of the European X-ray Free-Electron Laser (EuXFEL) provide superior temporal resolution compared with other X-ray sources. In combination with MHz X-ray microscopy techniques, it offers a unique opportunity to achieve superior contrast and spatial resolution in applications demanding high temporal resolution. In both live visualization and offline data

BACKGROUND: Galectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclonal antibody pembrolizumab. We aimed to assess if the effect of Gal-3 was a result of direct interaction with the immune checkpoint receptor.METHODS:

Galectin-3 is involved in multiple pathways of many diseases, including cancer, fibrosis, and diabetes, and it is a validated pharmaceutical target for the development of novel therapeutic agents to address unmet medical needs. Novel 1,2-thiodisaccharides with a C-glycosylic functionality were synthesized by the photoinitiated thiol-ene click reaction of O-peracylated 1-C-substituted glycals and 1

In recent years reprogramming techniques, differentiation protocols, and sequencing analysis have opened a field for generating and studying human-derived neurons with greater potential than ever before. This has generated a large number of studies with the goal of deriving bona fide neurons. Both direct reprogramming and differentiation have benefits and drawbacks, while direct reprogramming can

RationaleThere is no effective disease modifying treatment for peanut allergy available. A Phase I safety and tolerability study was performed with a chemically modified, Al(OH)3 adsorbed peanut extract (HAL-MPE1) for subcutaneous immunotherapy (SCIT).MethodsIn a randomized, double-blind, placebo controlled, single-centre, Phase I study, 17 Caucasian subjects with peanut allergy were randomized to