Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS - A Novel Therapeutic Opportunity.
ClinicalTrials.gov NCT01802697.
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ClinicalTrials.gov NCT01802697.
Objectives: The aim of this study was to explore the frequency of malnutrition risk and associated risk of falling, social and mental factors among elderly without home-help service. The aim was also to explore factors associated with risk of falling. A cross-sectional design was used. Elderly persons own homes. Data were collected during preventive home visits to 565 elderly (age range 73-90 year
Background: The Gtr1 protein of Saccharomyces cerevisiae is a member of the RagA subfamily of the Ras-like small GTPase superfamily. Gtr1 has been implicated in various cellular processes. Particularly, the Switch regions in the GTPase domain of Gtr1 are essential for TORC1 activation and amino acid signaling [R. Gong, L. Li, Y. Liu, P. Wang, H. Yang, L. Wang, J. Cheng, K. L. Guan, Y. Xu, Genes De
Daylight plays a major role in making atrium spaces appealing to building users. This appeal is also evident in the spaces adjoining the atrium. A key component of atrium daylighting, especially in tall atria, is the daylight reflected on to the atrium walls. This study examines the impacts of well geometries and different diffuse reflectance distributions of walls on variations of vertical intern
Ground level ozone [ozone] is considered a harmful air pollutant but there is a knowledge gap regarding its long term health effects. The main aim of this study is to develop local Land Use Regression [LUR] models that can be used to study long term health effects of ozone. The specific aim is to develop spatial LUR models for two Swedish cities, Umea and Malmo, as well as a temporal model for Mal
The BACE1 gene encodes the beta-site APP-cleaving enzyme 1 and has been associated with Alzheimer's disease (AD). BACE1 is the most important beta-secretase responsible for the generation of Alzheimer-associated amyloid beta-proteins (A beta) and may play a role in the amyloidogenic process in AD. We hypothesized that BACE1 gene variants might influence BACE1 activity or other markers for APP meta
P>Photoreceptor degeneration is the hallmark of a group of inherited blinding diseases collectively termed retinitis pigmentosa (RP); a major cause of blindness in humans. RP is at present untreatable and the underlying neurodegenerative mechanisms are largely unknown, even though the genetic causes are often established. The activation of calpain-type proteases may play an important role in cell
There is growing interest in the use of arbuscular mycorrhizal fungi (AMF) for ecological restoration. Numerous commercial AMF products are now available and are often used in preference to collecting indigenous AMF in treating restoration plants. Commercial AMF products are typically based on AMF strains exotic to the plant species and locations where they are used. We treated rooted cuttings of
This article analyses the path dependence of European copyright. It shows how copyright is legally constructed, is harmonised through international treaties and European regulatory efforts in terms of InfoSoc Directive and the IPRED, and is also affected by the Data Retention Directive and the Telecommunications Reform package. Furthermore, the “secretly” negotiated ACTA agreement is discussed as
The present study deals with Elastic Flow Rerouting (EFR)-an original traffic restoration strategy for protecting traffic flows in communication networks (including wireless networks) against multiple link failures. EFR aims at alleviating the trade-off between practicability of traffic restoration and the cost of network resources observed in existing networking solutions. We present an extension