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In this position paper we argue for a radical departure from today's approach to software engineering, centered on target-specific tools and general processes such as modeling and agile practices. The old principle of right tool for each problem shall be applied to software engineering as well: to address ever higher complexity, we need to raise dramatically the level of abstraction; as general so
Resource utilization is a very central issue in the development of large-volume embedded systems. Increasingly complex execution platforms for embedded multimedia systems challenge the prevailing approach of achieving high utilization by carefully tuned implementations in C and assembly language. The recently started ACTORS project addresses resource utilization by providing appropriate high-level
Firmware over the air (FOTA) is becoming a standard procedure for maintaining and updating wireless embedded systems. To cope with bandwidth and storage constraints this is facilitated using incremental updates based on delta technology, i.e. only the modifications are transmitted. The performance of a FOTA update is highly dependent on the size of the delta, and the type of modifications. Applica
Complex control systems are heterogeneous, in the sense of discrete computer-based controllers interacting with continuous physical plants, regular data sampling interleaving with irregular communication and user interaction, and multilayer and multimode control laws. This heterogeneity imposes great challenges for control system design in terms of end-to-end control performance modeling and simul
Background: The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer’s disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment barriers in the pre-dementia population are relatively under-reported. In a large European longitudinal biomarker study (the AMYPAD-PNHS), we investigated main en
Mucosal human papillomavirus (HPV) subtypes 16 and 18 are causative agents of cervical cancer, a leading cause of cancer-related deaths among women worldwide. In Japan, eggplant calyx is a folk remedy used to treat common warts. 9-oxo-(10E,12E)-octadecadienoic acid, isolated from eggplant calyx, may have antitumor effects. This study investigated the antitumor effects of 9-oxo-(10E, 12Z)-octadecad
To prevent diseases arising from exposure to toxic metals, more knowledge about their temporal changes is needed, especially in children, the most vulnerable group. This study follows temporal changes in blood lead (BPb), mercury (BHg) and cadmium (BCd) levels in schoolchildren (8–11 years old) from two cities in southern Sweden. One blood sample per 773 children was used for time trend analyses b
Cycloneuralians are ecdysozoans with a fossil record extending to the Early Cambrian Fortunian Age and represented mostly by cuticular integuments. However, internal anatomies of Fortunian cycloneuralians are virtually unknown, hampering our understanding of their functional morphology and phylogenetic relationships. Here we report the exceptional preservation of cycloneuralian introvert musculatu
Introduction: Hallux valgus (HV) is a common condition with impact on pain, function and HrQoL. International consensus does not exist on operative treatment of HV and population-level data regarding surgical treatment of HV is lacking. In this study we aimed to present base-line data from surgically treated HV patients reported to the Swedish register for foot and ankle surgery (Swefoot) during t
Common operational pictures (COPs) can be seen as collective problem representations that facilitate effective problem solving during emergency response. This article investigates how problems are represented in COPs and discusses how such problem representations could be improved to better inform ongoing response operations. A content analysis of 41 COPs created by a Swedish county board during t
Thin YBa2Cu3Ox films were grown on SrTiO3 or LaAlO3 single crystals by dc-magnetron reactive sputtering in argon/oxygen gas mixtures. Deposition temperatures ranged from 540 °C to 780 °C. After deposition and subsequent cool down, films grown above 680 °C are superconducting below 86–88 K. All films are oriented with the [001] direction parallel to the [001] substrate normal. The best films have c
Epitaxial TiN/NbN(001) superiattice thin films with periods A between 0 (alloy) and 9.6 nm have been grown by ultrahigh vacuum reactive magnetron sputter deposition on MgO(OOl) substrates in mixed Ar/N2 discharges. Cross-sectional transmission electron microscopy was used for characterizing layer and defect structure. Coherency strain relaxation close to the film/substrate interface resulted in no
Aims: An observational nationwide all-comers prospective register study to analyse outcomes after coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in unprotected left main coronary artery (LMCA) disease. Methods and results: All patients undergoing coronary angiography in Sweden are registered in the Swedish Web-system for Enhancement and Development of Evidence-b
Background: Radiostereometric analysis (RSA) studies have shown that the continuous migration of tibial components is predictive of aseptic loosening following total knee arthroplasty (TKA). In the present study, we investigated whether accurate sizing and placement of tibial components are related to the degree of implant migration as measured with use of RSA.Methods:A total of 111 patients who u
Epitaxial (001)-oriented Mo/V superlattice films with wavelengths of ≈ 5 nm have been grown on MgO(001) substrates, kept at 700°C, by dual-target unbalanced magnetron sputter deposition in Ar discharges. Low-energy (15-250 eV) Ar ion irradiation with incident ion-to-metal flux ratio of ≈ 1 during film growth was obtained through the application of a negative potential Vs to the substrate. The effe
Two-dimensional (2D) buried delta-function-shaped Sb-doping profiles have been obtained in Si using a low-energy accelerated Sb-ion source during molecular-beam epitaxy. A combination of secondary-ion mass spectrometry (SIMS), capacitance-voltage (C-V) measurements, and cross-sectional transmission electron microscopy (XTEM) was used to investigate dopant distributions and to determine profile wid
Introduction: Recycling of domestic waste and a number of employees in the recycling industry is expected to increase. This study aims to quantify current exposure levels of inhalable dust, endotoxin, and microorganisms and to identify determinants of exposure among recycling workers. Methods: This cross-sectional study included 170 full-shift measurements from 88 production workers and 14 adminis
Semi-coherent Y2O3 (yttria) inclusions are identified in high quality epitaxial YBa2Cu3Ox (YBCO) thin films by using transmission electron microscopy and energy dispersive X-ray analyses. Magnetization measurements show enhanced flux pinning in films containing an increasing number density of inclusions. The inclusions are incorporated into the films without disturbing the YBCO structure appreciab
The precipitation behavior, especially the early nucleation stages, of the industrial strip-cast Al3003 alloys was investigated by using transmission electron microscopy (TEM). An icosahedral quasicrystalline phase was found as secondary particles in these strip-cast alloys after heat treatment for a few seconds. Three different nucleation paths are proposed based on the TEM observations. They hav
Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM are still limited. Here, we have generated and characterized novel human telomerase reverse transcriptase (hTERT)-transduced mesothelial cell and mesothelioma-associated fibroblast (Meso-CAF) models and investigated their impact on PM cell gr
