The precisionFDA Truth Challenge V2 aimed to assess the state of the art of variant calling in challenging genomic regions. Starting with FASTQs, 20 challenge participants applied their variant-calling pipelines and submitted 64 variant call sets for one or more sequencing technologies (Illumina, PacBio HiFi, and Oxford Nanopore Technologies). Submissions were evaluated following best practices fo

Presentation av enkät till alla kliniker som opererar pacemaker och utvärdering av effekten/kunskapen om HRG's riktlinjer för pacemaker- och ICD-kirurgi

This research set out to identify pathways from vulnerability and stressors to depression in a global population of young athletes. Retrospective data were collected at age 18–19 years from Athletics athletes (n = 1322) originating from Africa, Asia, Europe, Oceania, and the Americas. We hypothesised that sports-related and non-sports-related stressors in interaction with structural vulnerability

To fulfill the increasing demand for high-speed electronics used for computation or communication is one everlasting challenge for the semiconductor industry. Emerging fields such as quantum computation also has a need for circuits operating at cryogenic temperatures. The metal-oxide-semiconductor field-effect transistor (MOSFET) is the main component in modern electronics, traditionally fabricate

The bioactivity, biological fate and cytotoxicity of nanomaterials when they come into contact with living organisms are determined by their interaction with biomacromolecules and biological barriers. In this context, the role of symmetry/shape anisotropy of both the nanomaterials and biological interfaces in their mutual interaction, is a relatively unaddressed issue. Here, we study the interacti

This article explores the role of values (Gehman, et al. 2013; Daskalaki et al. 2019) in the emergence and evolution of Grassroots Innovations (GIs) in the context of Argentina GIs are developed by communities as a means to overcome social exclusion while at the same time strive for a better future. GIs experience an intrinsic challenge: while they address social injustice, they are not able to ad

Aims: Ventricular longitudinal function measured as basal-apical atrioventricular plane displacement (AVPD) or global longitudinal strain (GLS) is a potent predictor of mortality and could potentially be a predictor of heart failure-associated morbidity. We hypothesized that low AVPD and GLS are associated with the combined endpoint of cardiovascular mortality and heart failure-associated morbidit

The formulation of semolina pasta with reduced starch digestibility is of prime importance to deal with the adverse effects of the intake of rapidly digested carbohydrates on human health. This work focused on the effects of the production method (extrusion and lamination) and the addition of commercial Type 2 resistant starch (RS) on the molecular organization and in vitro starch digestibility of

It is shown that the equation of motion of the one-particle Green function of an interacting many-electron system is governed by a multiplicative time-dependent exchange-correlation potential, which is the Coulomb potential of a time-dependent exchange-correlation hole. This exchange-correlation hole fulfills a sum rule, a generalization of the well-known sum rule of the static exchange-correlatio

Most adaptive controllers do not assume any a priori knowledge about the process to be controlled. In most situations there is, however, some knowledge about the process. This knowledge should be used to improve the performance compared to the “black box” approach of earlier adaptive controllers. The a priori knowledge is in this paper used in the estimation of the process and also in the design o

Background: Parents of young children are a vulnerable group with an increased risk of stress-related health problems compared to adults without children. Low occupational balance has been identified as a risk factor for stress-related disorders. Aim: The study aimed to describe occupational balance in parents of pre-school children and to explore potential differences between mothers and fathers.

Importance: Coverage of essential child health and nutrition interventions in low- and middle-income countries remains suboptimal. Adverse exposures, such as undernutrition and infections, are particularly harmful during the 1000 days from conception until 2 years of age.Objective: To investigate whether deaths in children younger than 5 years-which also reflect adverse exposures faced by children

IntroductionSmall bowel obstruction, infertility, and chronic abdominal pain are generally mentioned as the main clinical consequences of adhesion formation after abdominal surgery1,2. Difficulties experienced during reoperation are less pronounced consequences, but seem to have a huge impact. A large retrospective cohort study3 revealed that adhesiolysis was significantly associated with risk of

This Special Issue provides diverse multidisciplinary entry points that convey the multi-layered complexity of the interactions between radical right populism, gender issues, and religious questions. It fills a gap in the scholarship dealing with the political and social manifestations of radical right populism. From a theoretical point of view, the connections between radical right populism and g

We analyze the development of biodiversity offsetting governance through a research-weaving approach. Here, we combine information from a systematized review of the literature and a qualitative analysis of the institutional developments in different world regions. Through this triangulation, we synthesize and map the different developmental streams of biodiversity offsetting governance around the

Itch is a common symptom, but there is limited evidence on the prevalence of itch in children. The aim of this study was to assess the prevalence of itch in schoolchildren. A questionnaire was developed by experts in the field and based on a literature search. The questionnaire was applied in a pilot study of 25 consecutively selected paediatric patients and their parents. It confirmed the high co

Review-essay on ArkDes exhibition on Sigurd Lewerentz.

We used diblock poly(acrylic acid)-b-poly(2-dimethylamino ethyl methacrylate) (PAA-b-PDMAEMA) polyampholytes to prepare core-shell complexes with ionic surfactants. The dispersions have been characterized by means of small-angle X-ray scattering (SAXS), cryogenic transmission electron microscopy (Cryo-TEM), dynamic light-scattering, and zeta potential methods. Using cationic or anionic surfactants