Background: Multimorbidity has already become common in primary care and will be a challenge in the future. Primary care in Sweden participates to a great extent in the care of patients with two severe, chronic conditions: chronic obstructive pulmonary disease (COPD) and heart failure. Both conditions are characterized by high mortality and often coexist. Age, sex, heart failure and other comorbid

Många medarbetare och chefer i offentlig sektor vittnar om hur detaljstyrning, överdriven formbundenhet och felriktad mätning hindrar dem från att göra ett gott arbete. De upplever att verksamheten styrs och leds med fjärrkontroll och med bristande lyhördhet för behoven längst ut i styrkedjan. Forskningen pekar i samma riktning. Det här leder inte bara till minskad motivation och arbetsglädje, uta

BACKGROUND: Hip fractures are a common problem in the ageing population. Hip arthroplasty is the common treatment option for displaced intracapsular neck of femur fractures. Even though hip replacements are successful in restoring mobility, reducing pain and diminishing loss of health-related quality of life, the potential impact of a hip fracture on life expectancy as well as the postoperative mo

Ett antal rapporter under senare år har uppmärksammat oss på hur farlig ensamhet är för hälsan. Enligt vissa studier är den till och med farligare än rökning. Särskilt utsatta är äldre. Larmrapporterna har lett till flera debattinlägg, där man menar att politikerna måste ta ett större ansvar. Vissa pekar på Storbritannien, där man har inrättat en särskild ensamhetsminister. Men är ensamheten verkl

Agriculture and animal production have a great environmental impact, which is steadily growing. In a previous article, we highlighted how biodiversity is vital for agricultural production, emphasizing the role of animal pollinators. Here, we discuss the different dimensions of food security and the key role of our food choices in the cities to drive land use in rural areas and minimize the environ

Esaias Tegnérs (1782–1846) författarskap bildade länge centrum i den svenska kanon, och ansågs enligt utländska bedömare utgöra Sveriges främsta bidrag till världslitteraturen. På så vis har det haft stor betydelse för såväl den inhemska som utländska föreställningen om svensk kultur. Funktionen som enande nationalsymbol har Tegnér sedan länge förlorat, även om många fortfarande håller honom högt

PURPOSE: multiple myeloma is considered an incurable hematologic cancer but a subset of patients can achieve long-term remissions and survival. The present study examines the clinical features of long-term survival as it correlates to depth of disease response. PATIENTS & METHODS: this was a multi-institutional, international, retrospective analysis of high-dose melphalan-autologous stem cell

BACKGROUND: Oxytocin is an uterotonic drug with profound cardiovascular effects, which in compromised patients could lead to serious events. The objective was to investigate whether oxytocin affects cardiac function and vascular tone in large and small arteries. We hypothesized that oxytocin decreases arterial vascular tone and elevates cardiac output. METHODS: 51 pregnant women were randomised to

BACKGROUND: Several different IgA-proteases exist in Haemophilus influenzae. The variants have been suggested to play differential roles in pathogenesis, but there is limited information on their distribution in clinical isolates. The objective of this study was to investigate the distribution of IgA-protease genotypes in H. influenzae and assess the association between IgA-protease genotype and t

Fluctuation relations are powerful equalities that hold far from equilibrium. However, the standard approach to include measurement and feedback schemes may become inapplicable in certain situations, including continuous measurements, precise measurements of continuous variables, and feedback induced irreversibility. Here we overcome these shortcomings by providing a recipe for producing detailed

Estuarine sediments are key sites for removal of phosphorus (P) from rivers and the open sea. Vivianite, an Fe(II)-P mineral, can act as a major sink for P in Fe-rich coastal sediments. In this study, we investigate the burial of P in the Öre Estuary in the northern Baltic Sea. We find much higher rates of P burial at our five study sites (up to ĝ1/4 0.145 molĝ€†mĝ'2ĝ€†yrĝ'1) when compa

All-inorganic CsPbBr3 perovskite colloidal quantum dots have recently emerged as a promising material for a variety of optoelectronic applications, among others for multiphoton-pumped lasing. Nevertheless, high irradiance levels are generally required for such multiphoton processes. One strategy to enhance the multiphoton absorption is taking advantage of high local light intensities using photoni

The streaming instability is a promising mechanism to drive the formation of planetesimals in protoplanetary disks. To trigger this process, it has been argued that sedimentation of solids onto the mid-plane needs to be efficient, and therefore that a quiescent gaseous environment is required. It is often suggested that dead-zone or disk-wind structure created by non-ideal magnetohydrodynamical (M