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Soluble mass, hygroscopic growth, and droplet activation of coated soot particles during LACIS Experiment in November (LExNo)

The LACIS Experiment in November (LExNo) campaign was conducted in November 2005 at the Atmospheric Composition Change the European Network of Excellence (ACCENT) site Leipzig Aerosol Cloud Interaction Simulator (LACIS). The goal of LExNo was to provide deeper insight into the activation properties of coated soot particles imitating aged combustion aerosol particles. The aerosols were prepared by

Power and rationality in coastal planning: effects on participation and possibility in the management of barrier island dunes in Flagler Beach, Florida, USA

This article offers an empirical example of how power and rationality interact in coastal resource planning and management and reveals their implications for meaningful public participation in such processes. Participation has gained significant popularity over the last decades especially regarding the need to develop appropriate and democratic opportunities for meaningful public involvement in re

Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukemia

The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL patients and correlated the results with established CLL prognostic factors, time to treatment and over

Automated Selected Reaction Monitoring Software for Accurate Label-Free Protein Quantification.

Selected reaction monitoring (SRM) is a mass spectrometry method with documented ability to quantify proteins accurately and reproducibly using labeled reference peptides. However, the use of labeled reference peptides becomes impractical if large numbers of peptides are targeted and when high flexibility is desired when selecting peptides. We have developed a label-free quantitative SRM workflow

Glucose-Dependent Insulinotropic Polypeptide (GIP) Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature. GIP induces the expression of the pro-atherogenic cytokine osteopontin (OPN) in mouse arteries, via local release of endothelin-1 (ET-1) and activation of cAMP response element binding protein (CR

Laibach's Politics without a Cause or the Unsublated Contradiction

The article delves deeper into the theoretically perplexing practice of Slovenian music band Laibach, which draws links to Stalinism, fascism, Nazism and totalitarianism in general. The author presents a different reading than the more established Žižekian resolution of the issue via his introduction of the notion of ‘over-identification', meaning the critique of a regime by taking it more serious

Implementation of water calorimetry in a 180 MeV scanned pulsed proton beam including an experimental determination of k(Q) for a Farmer chamber

Water calorimetric measurements have been performed in a 180 MeV scanned pulsed proton beam and the absorbed dose determined has been compared with the results obtained using two NE2571 Farmer chambers and the IAEA TRS-398 code of practice. The depth of measurement in water corresponded to a residual range of R-res = 16.5 cm, corresponding to a mean energy of about 150 MeV. Ionization chambers wer

On user effect compensation of MIMO terminals with adaptive impedance matching

Proximity of user has been established as a major cause of performance degradation in multiple-input multiple-output (MIMO) terminals. Here, we investigate the potential of adaptive impedance matching (AIM) to improve the performance of two MIMO terminals in a free space (FS) and a two-hand (TH) user scenario, assuming uniform 3D angular power spectrum for the incoming signal. The results show tha

Variations in tropospheric submicron particle size distributions across the European continent 2008-2009

Cluster analysis of particle number size distributions from background sites across Europe is presented. This generated a total of nine clusters of particle size distributions which could be further combined into two main groups, namely: a south-to-north category (four clusters) and a west-to-east category (five clusters). The first group was identified as most frequently being detected inside and

Reproducibility of 3D delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the knee at 3.0 T in patients with early stage osteoarthritis

To assess the reproducibility of 3D delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 3 T in early stage knee osteoarthritis (OA) patients. In 20 patients, 3D dGEMRIC at 3 T was acquired twice within 7 days. To correct for patient motion during acquisition, all images were rigidly registered in 3D. Eight anatomical cartilage ROIs were analysed on both images of each patient. Capability of

Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity

Cyclin D1 and its binding partners CDK4/6 are essential regulators of cell cycle progression and are implicated in cancer progression. Our aim was to investigate a potential regulatory role of these proteins in other essential tumor biological characteristics. Using a panel of breast cancer cell lines and primary human breast cancer samples, we have demonstrated the importance of these cell cycle

L² Optimization in Discrete FIR Estimation: Exploiting State-Space Structure

This paper studies the L² (mean-square) optimal design of discrete-time FIR estimators. A solution procedure, which reduces the problem to a static matrix optimization problem admitting a closed-form solution, is proposed. In the latter solution, a special state-space structure of the associated matrices is exploited to obtain efficient formulae with the computational complexity proportional to th

Genetic variants in C-type lectin genes are associated with colorectal cancer susceptibility and clinical outcome

Inflammatory responses play a vital role at different stages of colorectal carcinogenesis. C-type lectins mediate inflammatory/immune responses and participate in immune escape of pathogens and tumors. Our study aimed to evaluate the correlation between polymorphisms in three C-type lectin genes, CD209, MBL2 and REG4, and colorectal cancer (CRC) risk and clinical outcome. We genotyped 15 potential

Reduced-rank spatio-temporal modeling of air pollution concentrations in the Multi-Ethnic Study of Atherosclerosis and Air Pollution

There is growing evidence in the epidemiologic literature of the relationship between air pollution and adverse health outcomes. Prediction of individual air pollution exposure in the Environmental Protection Agency (EPA) funded Multi-Ethnic Study of Atheroscelerosis and Air Pollution (MESA Air) study relies on a exible spatio-temporal prediction model that integrates land-use regression with krig

Solid-liquid-vapor metal-catalyzed etching of lateral and vertical nanopores.

Etching is an essential tool for the creation of nanostructures, where patterned metal structures can be used as masks. Here, we investigate HCl gas etching of InP substrates decorated with Au nanoparticles, and find that the etch rate is strongly increased at the Au-InP interfaces. The {111}A facets of the InP are preferentially etched. The metal nanoparticles follow in the etch direction, thereb