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Predicting sample success for large-scale ancient DNA studies on marine mammals

In recent years, nonhuman ancient DNA studies have begun to focus on larger sample sizes and whole genomes, offering the potential to reveal exciting and hitherto unknown answers to ongoing biological and archaeological questions. However, one major limitation to such studies is the substantial financial and time investments still required during sample screening, due to uncertainty regarding succ

Risk prediction for renal cell Carcinoma : Results from the European Prospective Investigation into Cancer and nutrition (EPIC) prospective cohort study

Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants from the European Prospe

The Podovirus ϕ80-18 Targets the Pathogenic American Biotype 1B Strains of Yersinia enterocolitica

We report here the complete genome sequence and characterization of Yersinia bacteriophage vB_YenP_ϕ80-18. ϕ80-18 was isolated in 1991 using a Y. enterocolitica serotype O:8 strain 8081 as a host from a sewage sample in Turku, Finland, and based on its morphological and genomic features is classified as a podovirus. The genome is 42 kb in size and has 325 bp direct terminal repeats characteristic

Teaching to write control code

Regulators are conceived as dynamic systems, but almost invariantly implemented as computer code. In the opinion of the authors the relationships between those two worlds are frequently overlooked in control education, although an insufficient knowledge of the involved concepts can hinder the correct operation of the realised systems. This manuscript presents a didactic activity that aims at closi

Toward a deeper use of feedback control in the design of critical computing system components

Feedback controllers are typically applied to computing systems by acting on some quantities ("tunable parameters" in the computer science lexicon, think e.g. of a packet drop rate) in order to attain some goal (e.g., a required bandwidth allocation). In other words, control loops are closed around the computing system, that exposes tunable parameters as control actuators, and allows to measure so

Self-aware adaptation in FPGA-based systems

Self-Aware Adaptive computing systems are capable of adapting their behavior and resources thousands of times based on changing environmental conditions and demands. This allows them to automatically find the best way to accomplish a given goal with the resources at hand. This capability would benefit the full range of computer systems, from embedded devices to servers to supercomputers. Although

On the hausdorff dimension of bernoulli convolutions

We give an expression for the Garsia entropy of Bernoulli convolutions in terms of products of matrices. This gives an explicit rate of convergence of the Garsia entropy and shows that one can calculate the Hausdorff dimension of the Bernoulli convolution νβ to arbitrary given accuracy whenever β is algebraic. In particular, if the Garsia entropy H(β) is not equal to log(β) then we have a finite t

Socio-ecological factors shape the opportunity for polygyny in a migratory songbird

Why females pair with already mated males and the mechanisms behind variation in such polygynous events within and across populations and years remain open questions. Here, we used a 19-year data set from a pied flycatcher (Ficedula hypoleuca) population to investigate, through local networks of breeding pairs, the socio-ecological factors related to the probability of being involved in a polygyno

Towards a comprehensive optimization of engine efficiency and emissions by coupling artificial neural network (ANN) with genetic algorithm (GA)

In response to the stringent emission regulations, artificial neural network (ANN) coupled with genetic algorithm (GA) is employed to optimize a novel internal combustion engine strategy named direct dual fuel stratification (DDFS). An enhanced ANN model is introduced to improve the accuracy and stability of predictions. Compared to the conventional computational fluid dynamics (CFD)-GA optimizati

Effect of mindfulness on physical activity in primary healthcare patients : a randomised controlled trial pilot study

Increased physical activity can have health benefits among inactive individuals. In Sweden, the healthcare system uses physical activity on prescription (PAP) to motivate patients to increase their physical activity level. Mindfulness may further heighten the internal motivation to engage in physical activity. However, previous research has not demonstrated clear evidence of such an association.AI

Mutational spectrum of de novo NPM1-mutated acute myeloid leukemia patients older than 75 years

AML with mutated NPM1 occurs in all age groups. Yet, the mutational pattern is not extensively studied in the very old, which may hamper appropriate risk assessment. Herein we examined 22 cases of NPM1-mutated de novo AML in patients older than 75, with a median age of 84. All diagnostic samples were sequenced aiming for coverage of the most relevant AML-associated mutations. For comparison with y

Controlled experimentation in continuous experimentation : Knowledge and challenges

Context: Continuous experimentation and A/B testing is an established industry practice that has been researched for more than 10 years. Our aim is to synthesize the conducted research. Objective: We wanted to find the core constituents of a framework for continuous experimentation and the solutions that are applied within the field. Finally, we were interested in the challenges and benefits repor

Critical realism in empirical research: employing techniques from grounded theory methodology

Whilst critical realism (CR) is becoming recognised as a significant meta-theory for the social sciences, there is little guidance on how to produce research which is consistent with its ontological and epistemological assumptions. This article contributes to an emerging discussion about how CR can be applied, drawing on an example of a qualitative study that has sought to understand and explain t

Normal incidence transmission loss of sandwich structures in a plane wave tube

The Transmission Loss of different kind of layered structures is investigated by means of a four microphone technique in a plane wave tube. By using the decomposition technique, incident, reflected and transmitted contributions are separated and transmission coefficient is easily calculated. In this paper a single measurement approach based on transfer matrix, taking into account reflection contri

Requirements for the Induction of Adaptive Immune Responses to Rotavirus

Rotavirus (RV) infections remain the leading cause of world-wide diarrhea-associated morbidity and mortality among children 200,000 deaths annually mostly in the low-income countries of Africa and Asia. Efficient clearance of the primary RV infection and protection from future re-infections is mediated by adaptive immune responses. The aim of the work presented in this thesis was to investigate th