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Background and aims: The treatment of locally advanced rectal cancer often consists of neoadjuvant chemoradiotherapy followed by surgery. However, approximately 15% of patients show no response to this neoadjuvant chemoradiotherapy. This systematic review aimed to identify biomarkers of innate radioresistant rectal cancer. Method: Through a systematic literature search, 125 papers were included an
Background: Depression and anxiety are risk factors for patients with myocardial infarction (MI). However, the association of a previous psychiatric diagnosis of anxiety or depression, or only such self-reported symptoms, with cardiovascular outcomes and mortality post-MI has not been previously examined in the same nationwide cohort. Methods: We linked demographic, socioeconomic and clinical data
Wastewater treatment plant (WWTP) nutrient recovery has recently gained traction in the search for new pathways for fertilizer production. In particular, concentrated waste streams such as reject water from sludge digestion are suitable. The environmental impact of a novel nutrient recovery technology using a membrane contactor (NPHarvest) was examined with an environmental life cycle assessment (
Objective: To study whether a revision of CTG guidelines and educational program influenced the perceived need for intervention by residents in obstetrics and gynecology. A secondary aim was to study the sensitivity and specificity of the classification pathological after classification by residents using two different guidelines in identifying neonates with acidemia. Study design: Cardiotocograms
Background: Postoperative pain is common but often difficult to assess, and there are many potential confounders. Over the last decades, the gender of investigator as well as participant has been found to influence pain perception in both preclinical and clinical studies. However, to our knowledge this has not been studied in various postoperative patients. Objectives of this study were to test th
Things are far from usual in the world right now. We have suffered two years of restrictions, closures, and shortages because of a global health crisis. A war in Europe has caused supply chain disruptions and energy price shocks. The United Kingdom’s exit from the European Union has hindered cross-border movement of capital (both human and physical) in Europe. And we are witnessing an increased fr
Undernutrition and diarrhea cause stunted growth and poor child health. Refrigerators allow consumption of perishable foods and reduce food contaminations causing diarrhea. This study used 188 Demographic and Health Surveys from 66 low- and middle-income countries with adjusted regressions and coarsened exact matching, comparing children within the same neighborhoods and narrow groups of household
The third generation of innovation policy focusing on addressing societal challenges requires collaborative engagement and action across a broad base of stakeholders over time to contribute to ambitious missions and transform societal systems. The strategic governance of such collaborative work in innovation ecosystems requires a collective vision and direction, a shared view on what to do, and a
Den här rapporten beskriver och analyserar sex svenska innovationsplattformar för hållbara och attraktiva städer. De studerade innovationsplattformarna finns i Borås, Göteborg, Kiruna, Lund, Stockholm och Umeå och har startats och bedrivits med projektstöd av Vinnova i form av en särskild satsning på innovationsplattformar i städer.
Cluster-based programmes are used by regions across the globe as part of their industrial, innovation and development policies. They have become a key tool in smart specialisation strategies and are increasingly used to address social challenges. The contemporary popularity of cluster policies reflects the complexity of innovation and production processes, which places a premium on effective colla
North Middle Sweden took part in a pilot “Regions in Industrial Transition”, launched by the European Commission to test new approaches to dealing with industrial transition. By focusing on specific challenges related to industrial transition, the pilot sought to develop new tools for regions and cities.
There has not been a satisfying numerical validation of the theory of effective waves in random particulate materials. Validation has been challenging because the theoretical methods for effective waves have been limited to random particulate media in infinite slabs or half-spaces, which require a very large number of particles to perform accurate numerical simulations. This paper offers a solutio
Central and Eastern Europe (CEE) needs to become an attentive listener if its countries want to advocate for its interests more effectively. With the war in Ukraine ongoing and the challenge of the country’s reconstruction looming on the horizon, the regional decision-makers have to show more understanding of the challenges faced by their partners in other parts of the continent. They also need to
Social work with homeless/ness in Sweden is usually performed by social services in local municipalities highly dependent on local, non-state actors, especially landlords’ goodwill, to cooperate with social services and support vulnerable peoples’ housing. The social services dependency on such actors is challenging and exploitation by landlords can affect the actual organization of social service
As products and supply chains (SCs) evolve, logisticians must revisit their under-standing of postponement. The postponement boundary problem acknowledges that value- adding operations' timing and location in global SCs are critical decisions, impacted by taxes and government regulations in different jurisdictions. However, when combining hardware and software objects, software's increasing import
Global supply chain management concerns the management of sourcing, manufacturing, and distribution that take place in different countries before a product is sold and delivered to the final buyers. From the view of the focal manufacturing firm, a global supply chain consists of three key parts: the upstream supply network, the manufacturing network of plants belonging to the focal firm, and the d
