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Cancer diagnoses among older people with intellectual disability compared with the general population : a national register study

BACKGROUND: Cancer occurrence among older people with intellectual disability (ID) is poorly documented, so we investigated the frequency and distribution of cancer in older people with ID compared with the general population.METHOD: People with ID who were ≥55years old and alive at the end of 2012 (n = 7936; ID cohort) were identified through a national register of people with ID who received soc

Amplitude and Phase Estimation for Absolute Calibration of Massive MIMO Front-Ends

Massive multiple-input multiple-output (MIMO) promises significantly higher performance relative to conventional multiuser systems. However, the promised gains of massive MIMO systems rely heavily on the accuracy of the absolute front-end calibration, as well as quality of channel estimates at the base station (BS). In this paper, we analyze user equipment-aided calibration mechanism to estimate t

l-Serine synthesis in the central nervous system : A review on serine deficiency disorders

The de novo synthesis of the amino acid l-serine plays an essential role in the development and functioning of the central nervous system (CNS). l-Serine displays many metabolic functions during different developmental stages; among its functions providing precursors for amino acids, protein synthesis, nucleotide synthesis, neurotransmitter synthesis and l-serine derived lipids. Patients with cong

Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics

Three-phosphoglycerate dehydrogenase (3- PGDH) deficiency is a rare recessive inborn error in the biosynthesis of the amino acid L-serine characterized clinically by congenital microcephaly, psychomotor retardation, and intractable seizures. The biochemical abnormalities associated with this disorder are low concentrations of L-serine, D-serine, and glycine in cerebrospinal fluid (CSF). Only two m

Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) : A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD

Objectives The aims of this study were to update the evidence on the incidence and prevalence rates of vaccine preventable infections (VPI) in patients with autoimmune inflammatory rheumatic diseases (AIIRD) and compare the data to the general population when available. Methods A literature search was performed using Medline, Embase and Cochrane library (October 2009 to August 2018). The primary o

Complications of surgery for gastro-entero-pancreatic neuroendocrine neoplasias

Purpose: Surgery is recommended for most patients with gastro-entero-pancreatic neuroendocrine neoplasias (GEP-NENs). Rates of complications and perioperative mortality have been reported in few mostly retrospective single-center series, but there has been no detailed analysis on risk factors for perioperative complications and mortality to date. Methods: Data of patients with GEP-NENs operated be

Long-term outcome of pT1a–b, cN0 breast cancer without axillary dissection or staging : a prospective observational study of 1543 women

Background: The implementation of screening programmes in Sweden during the mid-1990s increased the number of small node-negative breast cancers. In this era before staging by sentinel node biopsy, routine axillary dissection for staging of early breast cancer was questioned owing to the increased morbidity and lack of perceived benefit. The long-term risk of axillary recurrence when axillary stag

Periodontitis and airflow limitation in older Swedish individuals

Aim: To investigate whether there was an association between periodontitis and airflow limitation in older Swedish individuals. Materials and Methods: Study individuals were randomly selected from the Swedish civil registration database representing the ageing population in Karlskrona, Sweden. Clinical and radiographic examinations were performed, alongside which participants completed questionnai

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Abstract in German:Das Hochleistungs-Innenrundschälschleifen mit galvanisch gebundenen CBN-Schleifwerkzeugen ist ein hocheffizientes Fertigungsverfahren für die Innenbearbeitung von gehärteten Futterbauteilen wie Zahnrädern und Lagerringen. Die konturierten Schleifwerkzeuge, welche mit einer konischen Schrupp- und zylindrischen Schlichtzone versehen sind, kombinieren in einem einzelnen Axialhub ei

A 24-Year Follow-up Study on Recidivism in Male Mentally Disordered Sexual Offenders With and Without Psychotic Disorders

There is a lack of knowledge on mentally disordered sex offenders (MDSOs) targeting adult victims, especially regarding recidivism patterns and the specific subgroup with psychiatric disorders. This paper presents index offense data, clinical data, and recidivism patterns over up to 24 years in a cohort of 146 MDSOs, with and without psychotic disorders, sentenced in Sweden between 1993 and 1997.

Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease

Purpose: In vivo Alzheimer’s disease (AD) biomarkers for tau pathology are cerebrospinal fluid (CSF) phosphorylated tau (p-tau) and [18F]flortaucipir positron emission tomography (PET). Our aim was to assess associations between CSF p-tau with [18F]flortaucipir PET and the associations of both tau biomarkers with cognition and atrophy. Methods: We included 78 amyloid positive cognitively impaired

The public and geese : a conflict on the rise?

Wild geese are increasing in agricultural and urban settings across Europe, leading to widespread human–geese interactions. This study examined how the public’s acceptance of geese (attitude and acceptance capacity) varied depending on place dimensions, interactions with geese in different settings (place-based experience), and psychological factors, including wildlife value orientations, beliefs

Infections are associated with increased risk of giant cell arteritis - a population-based case-control study from Southern Sweden

Objective To investigate the association of infections with the subsequent development of giant cell arteritis (GCA) in a large population-based cohort from a defined geographic area in Sweden.Methods Patients diagnosed with biopsy-confirmed GCA between 2000 and 2016 were identified through the database of the Department of Pathology in Skåne, the southernmost region of Sweden. For each GCA case,

Discovery of an Exceptionally Strong β -Decay Transition of F 20 and Implications for the Fate of Intermediate-Mass Stars

A significant fraction of stars between 7 and 11 solar masses are thought to become supernovae, but the explosion mechanism is unclear. The answer depends critically on the rate of electron capture on Ne20 in the degenerate oxygen-neon stellar core. However, because of the unknown strength of the transition between the ground states of Ne20 and F20, it has not previously been possible to fully con

The future of evacuation drills : Assessing and enhancing evacuee performance

Evacuation drills are generally the main mechanism for improving or measuring occupant performance in emergency situations, but their effectiveness is often hard to measure, and there is limited evidence for sustained training benefits. However, innovations in technology (e.g., augmented/virtual reality, novel sensors and wearable tech) offer (when combined with new approaches to designing and del

Local attitudes towards management measures for the co-existence of seals and coastal fishery - A Swedish case study

Marine mammals and coastal fisheries are two features commonly associated with thriving marine environments, but it is also a case of wildlife impact on human interests. This paper analyses the seal-fisheries encounter in a Swedish Baltic Sea fishery. The problem concerns seals eating fish from the fishing gear which causes considerable economic losses to small-scale fishermen. This mixed-method s

Does Knee Prosthesis Survivorship Improve When Implant Designs Change? Findings from the Australian Orthopaedic Association National Joint Replacement Registry

BACKGROUND: TKA generally has excellent long-term survivorship. When a new knee system supersedes a previous model, increased survivorship, improved functional performance, or both may be expected, because key areas of design modification are often targeted to address wear, stability, and the patellofemoral articulation. However, not all design changes are beneficial, and to our knowledge, knee ar

Recycling of worn out brake pads ‒ impact on tribology and environment

Disc brake systems are widely used on commercial vehicles for braking. The brake pads are usually replaced by new ones before being totally worn out. Current methods to deal with the replaced brake pads include landfill and combustion, resulting in a huge waste of resources and increase of CO2 footprint. From a sustainable point of view, this study aims to evaluate the feasibility of recycling rep

Does Estimated Pulse Wave Velocity Add Prognostic Information? : MORGAM Prospective Cohort Project

The Reference Values for Arterial Stiffness Collaboration has derived an equation using age and mean blood pressure to estimated pulse wave velocity (ePWV), which predicted cardiovascular events independently of Systematic COoronary Risk Evaluation (SCORE) and Framingham Risk Score. The study aim was to investigate the independent association between ePWV and clinical outcomes in 107 599 apparentl