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Nanosecond Tracer Diffusion as a Probe of the Solution Structure and Molecular Mobility of Protein Assemblies: The Case of Ovalbumin

Protein diffusion is not only an important process ensuring biological function but can also be used as a probe to obtain information on structural properties of protein assemblies in liquid solutions. Here, we explore the oligomerization state of ovalbumin at high protein concentrations by means of its short-time self-diffusion. We employ high-resolution incoherent quasielastic neutron scattering

Tuning phase transitions of aqueous protein solutions by multivalent cations

In the presence of trivalent cations, negatively charged globular proteins show a rich phase behaviour including reentrant condensation, crystallisation, clustering and lower critical solution temperature metastable liquid–liquid phase separation (LCST–LLPS). Here, we present a systematic study on how different multivalent cations can be employed to tune the interactions and the associated phase b

Nationalmuseum undergoing change

Behandlar premisserna för Nationalmuseums framtida verksamhet när det gäller renovering och nybyggnation på Blasieholmen.

Program for studying intergenerational transmissions in infant mortality using the intermediate data structure (IDS)

Studies conducted in historical populations and developing countries have evidenced the existence of clustering in infant deaths, which could be related to genetic inheritance and/or to social and cultural factors such as education, socioeconomic status or parental care. A transmission of death clustering has also been found across generations. One way of expanding the knowledge on intergeneration

Editorial

Historical Life Course Studies, a journal in population studies, aims to stimulate and facilitate the implementation of IDS (Intermediate Data Structure, a standard data format for large historical databases), and to publish the results from (comparative) research with the help of large historical databases. The journal publishes not only empirical articles, but also descriptions (of the construct

A comprehensive screening of copy number variability in dementia with Lewy bodies

The role of genetic variability in dementia with Lewy bodies (DLB) is now indisputable; however, data regarding copy number variation (CNV) in this disease has been lacking. Here, we used whole-genome genotyping of 1454 DLB cases and 1525 controls to assess copy number variability. We used 2 algorithms to confidently detect CNVs, performed a case-control association analysis, screened for candidat

Enhanced peak growth of global vegetation and its key mechanisms

The annual peak growth of vegetation is critical in characterizing the capacity of terrestrial ecosystem productivity and shaping the seasonality of atmospheric CO2 concentrations. The recent greening of global lands suggests an increasing trend of terrestrial vegetation growth, but whether or not the peak growth has been globally enhanced still remains unclear. Here, we use two global datasets of

Psychometric analysis of the Swedish panic disorder severity scale and its self-report version

Panic Disorder, with or without agoraphobia (PDA or PD, respectively), is a major public health problem. After having established a PD diagnosis based on the DSM or the ICD systems, the Panic Disorder Severity Scale (PDSS) is the most widely-used interview-based instrument for assessing disorder severity. There is also a self-report version of the instrument (PDSS-SR); both exist in a Swedish tran

Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition.

Habitat- and species-mediated short- and long-term distributional changes in waterbird abundance linked to variation in European winter weather

Aim: Many species are showing distribution shifts in response to environmental change. We explored (a) the effects of inter-annual variation in winter weather conditions on non-breeding distributional abundance of waterbirds exploiting different habitats (deep-water, shallow water, farmland) and (b) the long-term shift in the population centroid of these species and investigate its link to changes

Towards a feasible and representative pan-African research infrastructure network for GHG observations

There is currently a lack of representative, systematic and harmonised greenhouse gas (GHG) observations covering the variety of natural and human-altered biomes that occur in Africa. This impedes the long-term assessment of the drivers of climate change, in addition to their impacts and feedback loops at the continental scale, but also limits our understanding of the contribution of the African c

Safety and Effectiveness of Vedolizumab in Patients with Steroid-Refractory GI Acute GvHD : A Retrospective Record Review

Allogeneic hematopoietic cell transplantation can be curative in patients with hematological malignancies but carries a significant risk of graft-versus-host disease (GvHD). There are no standard treatments for steroid-refractory (SR) gastrointestinal (GI) acute GvHD (aGvHD). This multicenter, international, retrospective medical record review aimed to evaluate the off-label use of vedolizumab, a

Balancing east and west: Evidence from Finland’s regional GDPs, 1880–2010

During the last two centuries, Finland has undergone a dramatic transformation: from one of Europe’s poorer and more peripheral countries, to a fast-growing high-tech economy. Finland has proven successful in reaping the benefits of openness to trade by moving up the value-added ladder. The country went from being a supplier in furs and tar in the pre-industrial era, to industrializing by exportin

On new and current treatments for Diamond-Blackfan anemia

Diamond-Blackfan anemia (DBA) is a rare congenital disease where the patients suffer from macrocytic anemia due to reduced numbers of erythroid precursors in the bone marrow. Most patients carry mutations in ribosomal proteins, such as ribosomal protein S19 (RPS19), which causes deficient ribosome biogenesis and affects protein translation. Ribosomal protein mutations also cause increased apoptosi

Regional convergence and divergence in Sweden, 1860–2010 : Evidence from Swedish historical regional GDP data

Since industrialization, Sweden has experienced an amazing growth trajectory. In 1850, Sweden was a quite poor and peripheral country, with GDP levels close to the world’s average. One and a half centuries later, Sweden ranks among the richest countries in the world with GDP levels more than three times the world’s average (Schön 2013). Yet apart from a few case studies and some industry studies,

Investigation on a high-stratified direct injection spark ignition (DISI) engine fueled with methanol under a high compression ratio

This paper reports an investigation of a highly stratified methanol direct injection spark ignition (DISI) engine with a high compression ratio. The effects of the start of injection (SOI), spray-included angle, injection pressure, and spark timing (ST) on in-cylinder flow, fuel distribution, flame propagation, and engine performance are evaluated in detail. The combustion process of methanol DISI