This thesis describes an improvement of the glyoxylate ene reaction by using siamyl glyoxaylate and a development of the novel rearrangement of allyl benzyl ethers. The glyoxylate ene reaction was used as a key reaction in a 8-step synthesis of a Taxol A-ring building block. During the work with the ene reaction it was found that the ene component underwent a rearrangement to give arylbutanals in

Levosimendan, an inodilatory drag discovered using troponin C as a target protein, has a cardiac effect deriving from the calcium sensitization of contractile proteins. The aim of this study was to give further evidence that levosimendan binds to cardiac troponin C and that the binding involves amino acid residues on helix ε of the N-terminal domain of this calcium-binding protein. Nine organic mo

Importance: This follow-up study of extremely preterm (EPT) children (

Thee three-dimensional structure of calcium-loaded regulatory, i.e. N- terminal, domain (1-91) of human cardiac troponin C (cNTnC) was determined by NMR in water/trifluoroethanol (91:9 v/v) solution. The single-calcium-loaded cardiac regulatory domain is in a 'closed' conformation with comparatively little exposed hydrophobic surface. Difference distance matrices computed from the families of Ca2+

Neurochemical evidence indicates that cognitive impairment in dementia of Alzheimer type (DAT) is related to degeneration of cholinergic neurons in the brain. A pharmacological approach is treatment with a cholinesterase inhibitor such as tetrahydroaminoacridine (THA). THA treatment of 17 patients with DAT was studied with a double-blind crossover design with three types of treatment, THA + lecith

The proliferation of massive open online courses (MOOCs) has been a phenomenon in higher education but only recently the subject of academic literature. MOOCs combine the traditional ideas of cohort and guided learning with open access and a truly global classroom. With over twenty thousand learners attracted to such courses, we argue that they can be a powerful tool in advancing sustainability ed

OBJECTIVE: To study the relations between different types of acidemia in umbilical artery at birth, fetal heart rate patter'ns (FHR) during laobr and infant long-term outcome. METHODS: 2,981 cases with singleton term pregnancy were selected for retrospective case-control study. Fetal monitoring was performed periodically during labor and umbilical blood gas was analyzed at birth and the infants ou

Many activated sludge wastewater treatment control strategies have been proposed in the literature; however, the literature does not provide a clear basis for comparison of these strategies because of the many confounding influences that have an impact on the system. Complicating the evaluation is the lack of standard evaluation criteria. Simulations provide a cost-effective means for the evaluati

A series of comparative studies is suggested, focused on perceptions of outrigger canoes, and aimed at an increased understanding of the relationship between social relations, biodiversity, and sustainable development in Oceanic societies on small islands and in coastal areas undergoing rapid cultural change. After a critique of the recent notion that canoe-building in Polynesia developed as a res

Respiration in animals, plants and many bacteria is dependent on heme A, which functions as a prosthetic group in a-type cytochromes (terminal energy-transducing oxidases in the electron transport chain that reduce molecular oxygen to water). Heme A synthase catalyses a chemically very demanding reaction, the conversion of one specific methyl side-group of heme O to a formyl group of heme A. This