This paper is about line search for the generalized alternating projections (GAP) method. This method is a generalization of the von Neumann alternating projections method, where instead of performing alternating projections, relaxed projections are alternated. The method can be interpreted as an averaged iteration of a nonexpansive mapping. Therefore, a recently proposed line search method for su

Synthesis of doubly 3-O-coumarylmethyl-substituted thiodigalactosides from bis-3-O-propargyl-thiodigalactoside resulted in highly selective and high affinity galectin-3 inhibitors. Mutant studies, structural analysis, and molecular modeling revealed that the coumaryl substituents stack onto arginine side chains. One inhibitor displayed efficacy in a murine model of bleomycin-induced lung fibrosis

A variational method for computing conformational properties of molecules with Lennard-Jones potentials for the monomer-monomer interactions is presented. The approach is tailored to deal with angular degrees of freedom, rotors, and consists of the iterative solution of a set of deterministic equations with an annealing in temperature. The singular short-distance behavior of the Lennard-Jones pote

Solar influences on climate variability are one of the most controversially discussed topics in climate research. We analyze solar forcing of flood frequency in central Europe during spring and summer on interannual to multi-centennial timescales, integrating daily discharge data of the River Ammer (southern Germany) back to AD1926 (∼solar cycles 16-23) and the 5500-year flood layer record from va

Ninety-nine per cent of all parents visit child healthcare centres (CHCs) andall parents in Sweden are invited to parental groups organized by the childhealth service (CHS) during their child’s first year, but only 40% choose toattend. The overall aim of this thesis was to elucidate the group-based earlyparental support provided by the Swedish CHS from the perspective of CHCnurses and parents. A t

PurposeThe aim of the study is to understand how meaning is assigned to online searching by viewing it as a mundane, yet often invisible, activity of everyday life and an integrated part of various social practices.Design/methodology/approachSearching is investigated with a sociomaterial approach with a starting point in information searching as entangled across practices and material arrangements

In this paper we describe our approach to robotic skill representation and a prototypical implementation of a programming-by-demonstration approach that allows users to generate skills and robot program primitives for later re- finement and re-use. We intend to evaluate the applicability of this approach to high-level programming in a user study, which we also explain.

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system, and changes in GABAergic neurotransmission modulate the activity of neuronal networks. Gephyrin is a scaffold protein responsible for the traffic and synaptic anchoring of GABAA receptors (GABAAR); therefore, changes in gephyrin expression and oligomerization may affect the activity of GABAergic syna

The occurrence of heart disease in uraemic patients was evaluated from study of 94 autopsied cases of chronic renal failure. The most common autopsy-ascertained causes of death were congestive heart failure (37%), acute myocardial infarction (13%) and tamponading pericarditis (8%). Death from congestive heart failure was significantly more common among the patients aged 60 or more than in the youn

The serum concentration of cobalt (s-Co) was determined in 10 patients with various stages of renal failure and was compared with hemodynamic subsets. S-Co was elevated in most patients. S-Co did not correlate to cardiac index, but there was a significant correlation between s-Co and left ventricular end-diastolic pressure (r=0.67; p

Common transport models use the mixing height (MH) to determine turbulent coefficients and to obtain tracer concentrations in the planetary boundary layer (PBL). We conducted a pseudo data experiment to elucidate the impact of assimilating MHs to improve CO2 transport within the Stochastic Time-Inverted Lagrangian Transport model (STILT). Transport of CO2 was simulated for August 2006 with a recep

OBJECTIVE: Although weight history is relevant in predicting eating disorder symptom severity, little is known about its role in the etiology of anorexia nervosa (AN). This study aimed to determine whether BMI or BMI trajectory differed between individuals who later developed adolescent-onset AN and a comparison group of HCs between school grades 1 through 6.METHOD: This study was based on longitu

Involuntary retrieval of unwanted memories is a common symptom in several clinical disorders, including post-traumatic stress disorder. With an aim to track the temporal dynamics of such memory intrusions, we recorded electrophysiological measures of brain activity while participants engaged in a Think/No-Think task. We presented the left hand word (the cue) of previously encoded word pairs in gre

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