Although we have learned much about how the brain fuels its functions over the last decades, there remains much still to discover in an organ that is so complex. This article lays out major gaps in our knowledge of interrelationships between brain metabolism and brain function, including biochemical, cellular, and subcellular aspects of functional metabolism and its imaging in adult brain, as well

Importance: Hypochondriasis, also known as health anxiety disorder, is a prevalent, yet underdiagnosed psychiatric disorder characterized by persistent preoccupation about having serious and progressive physical disorders. The risk of mortality among individuals with hypochondriasis is unknown. Objective: To investigate all-cause and cause-specific mortality among a large cohort of individuals wit

The main protease Mpro, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four different libraries and detailed follow-up synthesis on the promising uracil-containing fragment Z604 derived from these libraries. Z604 shows time-dependent binding. Its inhibitory effect is sensitive to

Det här är en roman; den femte av mina kriminalromaner om Thierry av Liège, vilka utspelar sig under Tyska ordens innehav av Gotland 1398-1408.

Purpose: We assessed long-term outcomes in acutely admitted adult patients with delirium treated in intensive care unit (ICU) with haloperidol versus placebo. Methods: We conducted pre-planned analyses of 1-year outcomes in the Agents Intervening against Delirium in the ICU (AID-ICU) trial, including mortality and health-related quality of life (HRQoL) assessed by Euroqol (EQ) 5-dimension 5-level

As the world is trying to rid itself of its dependence on fossil fuels, the need for renewable energy is rapidly increasing. In the power distribution network (DN), this takes the form of distributed generation (DG) from renewable sources, such as photovoltaic (PV) power production. But as more DG is installed, it can lead to issues in the DN such as overloading and overvoltage when production is

Pop-up utställning på Gemla Galleri, Stockholm, organiserad av Möbeldesignmuseum. Utställningen visade ett antal exempel på svenska och internationella möbelklassiker från museets samling. Med utgångspunkt från Anna Wahlöös avhandling Att göra en klassiker (2017) som pågick mellan 231122-231230. .

Policies introduced by the Chinese government in the name of fighting terrorism, religious extremism and separatism have significantly reshaped the Xinjiang Uyghur Autonomous Region (XUAR)–even though securitization has not brought the ‘stability’ that the PRC government claims in its continuous defense of its policies. Analysis of Chinese legal documents can provide a clearer picture of the gover

Cerebral pares är ett samlingsnamn för en grupp funktionsnedsättningar som påverkar rörelseförmågan, och är den vanligaste orsaken till rörelsehinder hos barn. Cerebral pares orsakas av en hjärnskada som inträffar under fosterstadiet, vid födelsen, eller före två års ålder. Musklerna hos personer med cerebral pares har en mindre storlek än hos andra, vilket till viss del kan kompenseras av längre Cerebral palsy is an umbrella term for a group of neurological disorders, affecting motor function, movement and posture. Contractures, restrictions in the range of motion of joints, are a common problem affecting people living with cerebral palsy. In the present thesis, the effect of having a contracture on one knee, on the hazard for developing a contracture on the other knee, is explored. This

Plant size is a crucial functional trait with substantial implications in agronomy and forestry. Understanding the factors influencing plant size is essential for ecosystem management and restoration efforts. Various environmental factors and plant density play significant roles in plant size. However, how plant size responds to mean annual precipitation (MAP), mean annual temperature (MAT), and d

We studied the impact of estimated glomerular filtration rate (eGFR) based on either creatinine or cystatin C, or in combination, on vascular aging (aortic stiffness) and central hemodynamics (central systolic blood pressure) in a Swedish urban population with median 17 years of follow-up. Participants (n = 5049) from the population-based Malmö Diet and Cancer Study that underwent baseline examina

This open access anthology explores how legal proceedings in and out-of-court can be matched to the complex problems underlying disputes concerning child custody, residence and contact between parents. It focuses particularly on Nordic experiences of in and out-of-court mechanisms as means of resolving custody disputes. The findings by the internationally renowned contributors speak to an internat