ATTACHMENT of foot-and-mouth disease virus (FMDV) to its cellular receptor involves a long and highly antigenic loop containing the conserved sequence, Arg-Gly-Asp, a motif known to be a recognition element in many integrin-dependent cell adhesion processes1-7. In our original crystal structure of FMDV the Arg-Gly-Asp-containing loop ('the loop'), located between β-strands G and H of capsid protei

Exposure to elemental aluminum and its salts is unavoidable. Aluminum as a metal is present in transport, construction, packaging, and electronic equipment. Aluminum salts are present in consumer products, food items and drinking water, vaccines, drugs, and antiperspirants. Aluminum in vaccines and preparations for allergen-specific immunotherapy are the major sensitization sources. The predominen

Selenium in its organic and inorganic forms has been shown to inhibit the development of chemically induced, spontaneous and transplanted tumors. The present investigation was performed to study the effect of selenium (4 μg per ml of drinking water) on tumorigenesis of adenovirus‐type‐9‐induced breast fibroadenomas and on 1,2‐dimethylhydrazine‐induced bowel carcinogenesis in WF rats. It was found

We assess how global shocks propagate from global manufacturing firms to local service providers through a spatial variation in export-driven service demand. We show that a 1% increase in a localised measure of exporting increases sales of service firms by around 0.08%. We also show that this link is local as the effect fades away after just 20 km, that it is more pronounced with larger and foreig

Degrowth thought and strategies suffer from a tension between viewing the state as incapable of initiating transformational change and making a political appeal to it to do precisely this via targeted eco-social policies. While a small number of academic papers has theoretically addressed this tension, there is a lack in research on the strategic implications arising from conceptualizations of the

News item in section labelled "People, Companies in Cryogenics", about a new musical composition which was the result of a collaboration between John Weisend (scientist and CSA Board Chairman) of the European Spallation Source and Mike Edgerton of Lund University.

A high-Q, tunable, bandpass filtered amplifier structure is proposed which is based on a novel Q enhancement technique in N-path filters. Using Fourier series analysis, frequency response of an N-path filter as well as the aliasing effects which are present in it are derived. Frequency translation of unwanted contents at higher frequencies to the center frequency of the bandpass filter is called h

I became acquainted with the music of Ramon Lazkano in 2001 through his guitar pieces. I was immediately fascinated with his ideas and his sound palette; somehow, I associated his music to a range of color between white and gray. His is a musical language where harmonics work as shadows and offer glimpses of a music that lives within a very personal and unique instrumental treatment.Later, togethe

De novo lipogenesis, a hallmark for cancers is required for cellular transformation. Further it is believed that resistance to apoptosis and epithelial-to-mesenchymal-transition(EMT) facilitates metastasis via over-expression of anti-apoptotic Bcl-2. Previously we demonstrated that hsa-miR-195 targets BCL2, induces apoptosis and augmented the effect of etoposide in breast cancer cells. However, th

Allochthonous subsidies to marine ecosystems have mainly focused on biogeochemical cycles, but there has also been recent interest in how terrestrial carbon (C) influences marine food webs. In the Baltic Sea, pine (Pinus sylvestris) pollen is found in large amounts in shallow bays in early summer. Pollen is a significant C-source in freshwater ecosystems and may also be important in coastal food w

Chlorophenols are a class of chemicals commonly used in preservatives, disinfectants, algaecides, herbicides and pesticides. However, there is a growing evidence that these compounds are a threat to human health. This is alarming as many chlorophenols are common pollutants found in the global environment at potentially biohazardous levels. Despite chlorophenols being abundant, widely used and pois

AU Mic is a young planetary system with a resolved debris disc showing signs of planet formation and two transiting warm Neptunes near mean-motion resonances. Here we analyse three transits of AU Mic b observed with the CHaracterising ExOPlanet Satellite (CHEOPS), supplemented with sector 1 and 27 Transiting Exoplanet Survey Satellite (TESS) photometry, and the All-Sky Automated Survey from the gr