Rheumatoid arthritis (RA) is a systemic disease not only restricted to the joints, but can also be associated with the development of extra-articular manifestations. Extra-articular RA (ExRA) is of clinical importance because of the associated morbidity and increased risk of premature mortality compared with RA patients in general. The aims of this work were to identify patients with ExRA in early

Popular Abstract in English Prostate cancer is one of the most common cancers in the world and the second most common in men. The western world has the highest incidence rates. The causes of prostate cancer are not yet clear, however a number of risk factors have been identified such as familial history, ethnicity, diet and genetic events. Prostate cancer affects primarily elderly men with the majProstate cancer is the second most common cancer in men. In order to improve diagnosis and prognosis, new sensitive and specific biomarkers are needed. Tissue biomarkers carry expression and morphological information of the tissue where they are expressed. However their use is still limited by technological problems, lack of standardized procedures and inadequate interpretation. In this work we in

The opportunistic human pathogen Pseudomonas aeruginosa causes a wide range of diseases. To cross host innate immune barriers, P. aeruginosa has developed efficient strategies to escape host complement attack. In this study, we identify the 57-kDa dihydrolipoamide dehydrogenase (Lpd) as a surface-exposed protein of P. aeruginosa that binds the four human plasma proteins, Factor H, Factor H-like pr

Organometallic complexes containing terminal metal nitrides and phosphides are important synthetic reagents. Laser-ablated group 6 metal atoms react with NF3, PF3, and PCl3 to form the simple lowest energy N MF3, and P MX3 products following insertion and halogen transfer, with the exception of P CrF3, which is a higher energy species and is not observed. The E MX3 pnictide metal trihalide molecul

microRNAs (miRNAs) are widespread regulators of gene expression, but little is known of their potential roles in congenital muscular dystrophy type 1A (MDC1A). MDC1A is a severe form of muscular dystrophy caused by mutations in the gene encoding laminin α2 chain. To gain insight into the pathophysiological roles of miRNAs associated with MDC1A pathology, laminin α2 chain-deficient mice were evalua

Charged particle production in deep-inelastic ep scattering is measured with the H1 detector at HERA. The kinematic range of the analysis covers low photon virtualities, 5 < Q(2) < 100 GeV2, and small values of Bjorken-x, 10(-4) < x < 10(-2). The analysis is performed in the hadronic centre-of-mass system. The charged particle densities are measured as a function of pseudorapidity (n(*)) and trans

The dissertation is about career in working life – not career solely in the sense of climbing upwards in the organizational hierarchy to management level, but career as the movement that individuals or groups make over time through working life. The focus is on social workers and their professional field. The overall aim is to describe and analyse social workers’ career patterns and careers at the

Sixty-four Polish families with a history of breast and/or ovarian cancer were screened for mutations in the BRCA1/2 genes using a combination of denaturing high performance liquid chromatography (DHPLC) and sequencing. Two thirds (43/64; 67%) of the families were found to carry deleterious mutations, of which the most frequent were BRCA1 5382insC (n=22/43; 51%) and Cys61Gly (n=9/43; 20%). Two oth

2012 är året då tsunamin drabbade högre utbildning. Den öppna utbildningskulturen slår igenom på bred front i hela världen, bland annat genom att prestigeuniversitet, inte minst i USA, erbjuder kurser gratis online och globalt till alla. Men i Sverige är öppen utbildning ännu i hög grad en icke-fråga, speciellt bland myndigheter och utbildningsorganisationer.

The article examines the influence of linguistic distance on the labor market outcomes of a sample of 5,041 first generation immigrants in Sweden between 1970 and 1990. The article exploits register data from the Swedish Longitudinal Database, examining a population of individuals from 11 non-Nordic countries of origin. The analysis focuses on the transition to the Swedish labor market, comparing

Treatment in medical oncology is gradually shifting from the use of nonspecific chemotherapeutic agents toward an era of novel targeted therapy in which drugs and their combinations target specific aspects of the biology of tumor cells. Multiple myeloma (MM) has become one of the best examples in this regard, reflected in the identification of new pathogenic mechanisms, together with the developme

Popular Abstract in Uncoded languages A modern tartószerkezeti szabványok általában két fő követelményt támasztanak a tartószerkezetekekkel, illetve szerkezeti elemekkel szemben. Az egyik a tönkremenetellel szembeni biztonsághoz, míg a másik a használhatósághoz kapcsolódik. A szerkezeti használhatóság a tartószerkezet azon képessége, hogy tervezett szerepét élettartams során folyamatosan betöltse.In many design situations the acceptable performance of structures is defined by serviceability requirements. To estimate the probability of serviceability failure three main design aspects should be considered: (1) the relevant exposures, (2) the structural response and (3) the performance criteria. This thesis presents background information and new findings on structural serviceability related

In this work, the nucleation and growth of InAs nanowires on patterned SiO2/Si(111) substrates is studied. It is found that the nanowire yield is strongly dependent on the size of the etched holes in the SiO2, where openings smaller than 180 nm lead to a substantial decrease in nucleation yield, while openings larger than View the MathML source promote nucleation of crystallites rather than nanowi

The last several decades have seen an increase in male infertility concomitant with a decline in the birth sex ratio. The conditions are believed to be linked to increased exposure to endocrine disrupting chemicals (EDCs), including the persistent organic pollutants or lifestyle factors e.g. smoking. The mechanism behind the lowered birth sex ratio is unknown, but might be due to an EDC-induced sk

It has been proposed that vascular progenitor cells play an important role in vascular repair, but their possible clinical importance in cardiovascular disease has not been fully characterized. Vascular endothelial growth factor A, placental growth factor and stem cell factor (SCF) are three growth factors that are important in recruiting vascular progenitor cells. In this study, we investigated t

Ground-source heat pump systems use borehole heat exchangers to transfer heat to and from the ground. An important feature is the local thermal resistances between the heat carrier flow channels in the borehole and the surrounding ground. The counter-flow heat exchange between the pipes is also important, particularly for the axial temperature variation. These resistances can be represented by a t