Background: Accumulating evidence suggests that prenatal chemical exposure triggers epigenetic modifications that could influence health outcomes later in life. In this study, we investigated whether DNA methylation (DNAm) levels at the glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B) gene underlies the association between prenatal exposure to an endocrine disrupting chemical (EDC), bis

Epithelioid hemangioendothelioma (EHE) is an ultra-rare, translocated, vascular sarcoma. EHE clinical behavior is variable, ranging from that of a low-grade malignancy to that of a high-grade sarcoma and it is marked by a high propensity for systemic involvement. No active systemic agents are currently approved specifically for EHE, which is typically refractory to the antitumor drugs used in sarc

Proper irrigation scheduling and agricultural water management require a precise estimation of crop water requirement. In practice, reference evapotranspiration (ETo) is firstly estimated, and used further to calculate the evapotranspiration of each crop. In this study, two new coupled models were developed for estimating daily ETo. Two optimization algorithms, the shuffled frog-leaping algorithm

To bridge the pressure gap in heterogeneous catalysis and maximize the gain of operando information, we have combined PM-IRRAS with the imaging techniques SOR and PLIF and measured CO oxidation on a Pd(100) crystal.

This article intends to raise questions related to nationalism in South Asia, while also addressing the rationale for this special issue. Is nationalism a monolithic construct based on a European precedent or is it something much larger that is developed pluralistically in a variety of contexts around the world? If the latter is true, which is our position, then how do we go about studying the var

Background: Extracorporeal shock wave lithotripsy (ESWL) of kidney stones is losing ground to more expensive and invasive endoscopic treatments. Objective: This proof-of-concept project was initiated to develop artificial intelligence (AI)-augmented ESWL and to investigate the potential for machine learning to improve the efficacy of ESWL. Design, setting, and participants: Two-dimensional ultraso

CONTEXT: The epidemiological signature of renal cell carcinoma (RCC) during the past decades is explained by overdetection and overtreatment of indolent cancers; furthermore, a non-negligible proportion of patients undergoing surgery for suspected RCC harbour benign renal tumours. As the gold standard for RCC diagnosis remains histopathological analysis of surgical or biopsy specimens, implementat

We present the results of a study of the vortex lattice in the heavy fermion superconductor CeCu2Si2, using small-angle neutron scattering (SANS). In this material at temperatures well below Tc∼0.6 K, the value of the upper critical field Bc2∼2.2 T is strongly limited by the Pauli paramagnetism of the heavy fermions. In this temperature region, our SANS data show an increase in the magnetization o

The aggregation of the human islet amyloid polypeptide (IAPP) is associated with diabetes type II. A quantitative understanding of this connection at the molecular level requires that the aggregation mechanism of IAPP is resolved in terms of the underlying microscopic steps. Here we have systematically studied recombinant IAPP, with amidated C-terminus in oxidised form with a disulphide bond betwe

In this work we study shear reversals of dense non-Brownian suspensions composed of cohesionless elliptical particles. By numerical simulations, we show that a new fragility appears for frictionless ellipses in the flowing states, where particles can flow indefinitely in one direction at applied shear stresses but shear jam in the other direction upon shear stress reversal. This new fragility, abs

Bidraget innehåller en omfattande presentation av de rättsliga bestämmelserna för gottgörelse för nationalsocialistiska orättvisor – i synnerhet för återlämnande av egendom till judiska offer för Förintelsen – med hjälp av det exempel som utgörs av Förbundsrepubliken Tysklands lagstiftning. Vidare ägnar sig bidraget åt en kontextualisering av gottgörelse- och reparationspolitiken i termer av folkr

The results of the project SSM2019-5225, “Marine 14C levels around the Swedish coast”, financed by the Swedish Radiation Safety Authority (SSM), are presented in the paper “Spatial and temporal variations of 14C in Fucus spp. in Swedish coastal waters” published in the Journal of Environmental Radioactivity. The project SSM2019-5225 focussed on spatial variations in 14C in Fucus spp. samples colle

Background: Depressed suicide attempters are, according to some earlier studies, treated more often with antipsychotics than depressive non-suicide attempters. Cluster B personality disorders, especially borderline personality disorder, are associated with a high suicide risk, and antipsychotics are commonly used for the reduction of symptoms. However, no previous study has taken comorbid personal

Background: Self-care behavior is important in avoiding hospitalization for patients with heart failure (HF) and refers to those activities performed with the intention of improving or restoring health and well-being, as well as treating or preventing disease. The purpose was to study the effects of a home-based mobile device on self-care behavior and hospitalizations in a representative HF-popula