Background: The Btk (Bruton's tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinases with distinct functional domains PH, TH, SH3, SH2, and kinase. Mutations have been observed in each of the Btk subdomains in XLA. We have analyzed the Btk gene in six XLA pa

Prenylhydroxybenzoic acid derivatives and other two analogues previously reported were isolated from Piper arieianum leaves. The structures of the compounds were assigned from detailed spectroscopical analysis (NMR 1D and 2D and HR ESI TOF MS) data and by comparison with data from the literature. These molecules posses pungent activity different to that of capsaicin and their activity is related t

Local signs and symptoms were evaluated in 187 consecutively presenting diabetic patients undergoing amputation for foot ulcers. From admission until final outcome the patients were treated by the same multidisciplinary team both as in- and out-patients. At the time of amputation, the types of lesions were superficial/deep ulcer (n 17), ulcer with deep infection, but without gangrene (n 40), and g

A test of the benchmark QED process e(+) e(-) -->gammagamma(gamma) is reported, using the data collected with the DELPHI detector at LEP 2. The data analysed were recorded at centre-of-mass energies ranging from 161 GeV to 208 GeV and correspond to a total integrated luminosity of 656.4 pb(-1). The Born cross-section for the process e(+) e(-)-->gammagamma(gamma) was determined, confirming the vali

Total and cause specific mortality and cancer morbidity were studied among 1929 asbestos cement workers with an estimated median cumulative exposure of 2.3 fibre (f)-years/ml (median intensity 1.2 f/ml, predominantly chrysotile). A local reference cohort of 1233 industrial workers and non-case referents from the exposed cohort were used for comparisons. The risk for pleural mesothelioma was signif

Popular AbstractDetta är en histora över teorier om ojämnt utbyte och deras upphovsmän. Den börjar med merkantilismen och Richard Cantillons jordvärdeteori, ger en kort beskrivning av tidig klassisk ekonomi och Gerald Fitzhugh. Bland det tidiga 1900-talets marxistiska ekonomer spelade ojämnt utbyte en roll i Otto Bauers tolkning av nationalistiska motsättningar, och i Henryk Grossmanns verk som enThis is a history of theories and theorists of unequal exchange. Starting with mercantilists and Richard Cantillon's theory based on land values, it briefly covers the early Classical economists and Gerald Fitzhugh. Among early 20th century Marxist economists, unequal exchange appeared in Otto Bauer's explanation of nationalist antagonism, and in Henryk Grossmann as countering the breakdown of cap

More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has been identified. Also, the chronological order in which the aberrations appear during disease progression is not well known. One reason why our understanding of the cytogenetic evolution is unclear is

On the basis of text-internal evidence, the article supports the view that the soteriological doctrines of the Bhagavadgītā comprise a structured and progressive system in which partially conflicting elements derived from contemporary religious teachings have been deliberately arranged in hierarchical form, and touches on philological problems in connection with particular passages.

Background: Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ipsilateral middle cerebral artery. The present study aimed to examine the effect of the PKC inhibitor Ro-32-0432 on endothelin receptor upregulati