Recombinant cystatin C producing clones were isolated from a human placenta λgt11 cDNA library. The cDNA insert of one of the clones, containing 777 base pairs, encodes the complete mature cystatin C (120 amino acids) and a hydrophobic leader sequence of 26 amino acids, indicating an extracellular function of the inhibitor. The deduced protein sequence confirms the protein sequence of cystatin C i

We present an extensive investigation of the epitaxial growth of Au-assisted axial heterostructure nanowires composed of group IV and III-V materials and derive a model to explain the overall morphology of such wires. By analogy with 2D epitaxial growth, this model relates the wire morphology (i.e., whether it is kinked or straight) to the relationship of the interface energies between the two mat

Background. The incidence and severity of invasive group A streptococcal infection demonstrate great variability over time, which at least, in part, seems to be related to group A streptococcal type distribution among the human population. Methods. An enhanced surveillance study of invasive group A streptococcal infection (746 isolates) was performed in Sweden from April 2002 through December 2004

The Facility for Antiproton and Ion Research (FAIR), under construction at Darmstadt will provide intense relativistic beams of exotic nuclei at its Superconducting-FRagment Separator. High-resolution in-beam γ-ray spectroscopy will be performed in the HISPEC experiment, using the European Advanced GAmma-ray Tracking Array (AGATA). The PreSPEC-AGATA campaign is the predecessor of HISPEC and runs f

This paper outlines a case study in which a management development learning process was tightly coupled to organisational change and development objectives. The case discusses how a research and consulting team came together to develop highly reflexive pedagogy to support the work of internal managers who were organized into teams (learning sets) to undertake 'organisational problem solving'. Thes

This chapter provides a brief history of the evolution of medications used to treat anxiety and anxiety disorders, as described in the Diagnostics and Statistical Manual of Mental Disorders (DSM-IV-TR). We also summarize the efficacy and adverse effects data from clinical trials for these medications. Medication classes reviewed include antidepressants, benzodiazepines, beta-blockers, anticonvulsa

Recently, semiotics has begun to be related to computing. Since semiotics is about the interpretation of signs, of which language is a chief part, such an interest may seem quite reasonable. The semiotic approach is supposed to bring semantics to the computer. In this paper I discuss the realistic in this from the point of view of computers as linguistic systems, that is, as interpreters of descri

Homogenous charge compression ignition (HCCI) has been identified as a promising way to increase the efficiency of the spark-ignited engine, while maintaining low emissions. The challenge with HCCI combustion is excessive pressure rise rate, quantified here with Ringing Intensity. Turbocharging enables increased dilution of the charge and thus a reduction of the Ringing Intensity. The engine used

The deteriorating security environment in Europe due to the increasing conflict of interests between western democracies and Russia is now, after the Russian invasion of Ukraine, obvious to all. But the willingness of the Russian state to oppose and disrupt European security order and the sovereignty of other states is not new. One increasingly common way is using influence operations, often in co

ESSνSB is a design study for a next-generation long-baseline neutrino experiment that aims at the precise measurement of the CP-violating phase, δCP, in the leptonic sector at the second oscillation maximum. The conceptual design report published from the first phase of the project showed that after 10 years of data taking, more than 70% of the possible δCP range will be covered with 5σ C.L. to re

The first results from the stopped beam RISING experimental campaign performed at the GSI laboratory in Darmstadt, Germany, are presented. RISING (Rare ISotope Investigations at GSI) constitutes a major new experimental program in European nuclear structure physics research aimed at using relativistic energy (typically around 1 GeV per nucleon) projectile fragmentation reactions to populate nuclei

The pheromone-mediated upwind flight of male turnip moths was observed in a flight tunnel at different times of day under conditions of a light-dark (LD) cycle, constant darkness (DD), and a shifted photoperiod. Under both LD and DD conditions, a significantly larger number of males flew to the pheromone during both the scotophase and the subjective scotophase than during the photophase and the su

The concept of brain plasticity covers all the mechanisms involved in the capacity of the brain to adjust and remodel itself in response to environmental requirements, experience, skill acquisition, and new challenges including brain lesions. Advances in neuroimaging and neurophysiologic techniques have increased our knowledge of task-related changes in cortical representation areas in the intact

Experimental and numerical investigations of the ignition of hydrogen/air mixtures by jets of hot exhaust gases are reported. An experimental realisation of such an ignition process, where a jet of hot exhaust gas impinges through a narrow nozzle into a quiescent hydrogen/air mixture, possibly initiating ignition and combustion, is studied. High-speed laser-induced fluorescence (LIF) image sequenc

Sclerostin is the product of the SOST gene. Loss‐of‐function mutations in the SOST gene result in a high‐bone‐mass phenotype, demonstrating that sclerostin is a negative regulator of bone mass. Primarily expressed by osteocytes in bone, sclerostin is reported to bind the LRP5/6 receptor, thereby antagonizing canonical Wnt signaling and negatively regulating bone formation. We therefore investigate