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Pseudomonas aeruginosa infection correlates with high MFI donor-specific antibody development following lung transplantation with consequential graft loss and shortened CLAD-free survival
Background: Donor-specific antibodies (DSAs) are common following lung transplantation (LuTx), yet their role in graft damage is inconclusive. Mean fluorescent intensity (MFI) is the main read-out of DSA diagnostics; however its value is often disregarded when analyzing unwanted post-transplant outcomes such as graft loss or chronic lung allograft dysfunction (CLAD). Here we aim to evaluate an MFI
Immune Mechanisms in Parkinson's Disease and Epilepsy. Preclinical Findings and Clinical Perspectives.
Neural semantic effects of tone accents
This study investigated whether the brain utilizes morphologically induced tones for semantic processing during online speech perception. An auditory comprehension task was conducted while measuring event-related potentials (ERPs). The study tested whether a discrepancy between contextual expectations and the tonal realizations of the target word would yield an N400 effect, indicative of semantic
Global Consensus Recommendations on Improving the Safety of Chronic Total Occlusion Interventions
Safety is of critical importance to chronic total occlusion (CTO) percutaneous coronary intervention (PCI). This global consensus statement provides guidance on how to optimise the safety of CTO) PCI, addressing the following 12 areas: 1. Set-up for safe CTO PCI; 2. Guide catheter-–associated vessel injuries; 3. Hydraulic dissection, extraplaque haematoma expansion, and aortic dissections; 4. Haem
Related in Death? Further Insights on the Curious Case of Bishop Peder Winstrup and His Grandchild’s Burial
In 2021, we published the results of genomic analyses carried out on the famous bishop of Lund, Peder Winstrup, and the mummified remains of a 5–6-month-old fetus discovered in the same burial. We concluded that the two individuals were second-degree relatives and explored the genealogy of Peder Winstrup to further understand the possible relation between them. Through this analysis, we found that
The gut microbiota and diabetes : clarity on an emerging topic and introduction to a new partnership and journal feature
CSR in between the legal and the ethical: Mobilising legal frameworks through public discourse
Exploring Definitions and Predictors of Response to Biologics for Severe Asthma
Background: Biologic effectiveness is often assessed as response, a term that eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging. Objective: To explore definitions of biologic responders in adults with severe asthma and investigate patient characteristics associated with biologic response. Methods: This was a longitudinal cohort study using d
Association of MAFLD and MASLD with all-cause and cause-specific dementia : a prospective cohort study
Background: Liver disease and dementia are both highly prevalent and share common pathological mechanisms. We aimed to investigate the associations between metabolic dysfunction-associated fatty liver disease (MAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) and the risk of all-cause and cause-specific dementia. Methods: We conducted a prospective study with 403,506 partici
Emotions and Policy - Teachers' Emotional Labour Amidst Policy Demands
This paper examines the interplay between emotions, policy and teachers' experiences within the Swedish municipal school system. Through an anthropological lens, it examines how emotions are not only personal experiences but also culturally and socially conditioned phenomena that influence teachers' subjectivity and the way they navigate the overall goals and expectations of the school sys
Jämkning av avtalade ansvarsbegränsningar i kommersiella avtal - När är ansvarsbegränsningar oskäliga enligt 36 § Avtalslagen?
Avtalsfrihet är en grundläggande princip inom avtalsrätten, vilket innebär att parter är fria att själva bestämma vilka de vill ingå avtal med och vad de vill inkludera i ett avtal. I sitt avtal kan parterna ofta också välja att begränsa det ansvar som de eller någon av dem annars har. Exempelvis kan avtalet innehålla ansvarsbegränsningar från skadestånd eller beloppsbegränsningar av det kontraktThe freedom of contract is a principle in common contract law, freedom of contract means that two parties are free to arrange the content of the contract however they like. Because they are free to dispose of the contract themselves, they can choose to include a disclaimer clause. However, there are restrictions. Parties can not include disclaimer clauses however they like because to minimize and
Alkohol- och spelmarknadsföring - En studie om skillnader i reglering av alkohol- och spelreklam
I Sverige idag uppskattas det att 16 procent konsumerar alkohol på ett sätt som bedöms som riskbruk. Detta är något som kan ge upphov till en rad olika konsekvenser, såsom sjukdomar, skador och missbruk. Vidare visar studier att fyra procent av individer mellan 16-24 år lider av någon form av spelproblem. Precis som med alkohol kan det vid konsumtion av spel utvecklas ett missbruk. Det är konstateIn Sweden today it is estimated that 16 percent consume alcohol in a way that is considered risky. This is something that can give rise to a range of consequences, such as illness, injury and addiction. Furthermore, studies show that 4 percent of individuals aged 16-24, suffer from some form of gambling problem. As with alcohol, the consumption of gambling can lead to addiction. It is recognized t
Pareto optimization of SPECT acquisition and reconstruction settings for 177Lu activity quantification
Background: The aim was to investigate the noise and bias properties of quantitative 177Lu-SPECT with respect to the number of projection angles, and the number of subsets and iterations in the OS-EM reconstruction, for different total acquisition times. Methods: Experimental SPECT acquisition of six spheres in a NEMA body phantom filled with 177Lu was performed, using medium-energy collimators an
Long-term ambient air pollution exposure and renal function and biomarkers of renal disease
Background: Despite accumulating evidence of an association between air pollution and renal disease, studies on the association between long-term exposure to air pollution and renal function are still contradictory. This study aimed to investigate this association in a large population with relatively low exposure and with improved estimation of renal function as well as renal injury biomarkers. M
Machining of Compacted Graphite Iron : A review
Compacted Graphite Iron (CGI) represents a unique combination of the characteristics of grey and spheroidal cast irons, sparking significant interest over the past two decades, particularly as a favoured material in several automotive industry applications, including engine components and heavy-duty vehicle parts. Despite its growing prominence, the full potential of CGI remains underutilised, pri
Cod otoliths document accelerating climate impacts in the Baltic Sea
Anthropogenic deoxygenation of the Baltic Sea caused major declines in demersal and benthic habitat quality with consequent impacts on biodiversity and ecosystem services. Using Baltic cod otolith chemical proxies of hypoxia, salinity, and fish metabolic status and growth, we tracked changes from baseline conditions in the late Neolithic (4500 BP) and early twentieth century to the present, in ord
Nu vill alla klä sig som cowboys – och det är inte så konstigt
Extending the Life World : Phenomenological Triangulation Along Two Planes
Phenomenology is often mistakenly understood as both introspectionist and anthropocentric and thus as incapable of providing us with objective knowledge. While clearly wrong, such critiques force us to spell out how the life world that is given in human experience is in fact not anthropocentric and not incompatible with science. In this article we address this by adapting a recent proposal to exte