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OBJECTIVES: To develop and validate a recombinant vaccine to attenuate inflammation in arthritis by sustained neutralization of the anaphylatoxin C5a. METHODS: We constructed and expressed fusion protein of C5a and maltose binding protein. Efficacy of specific C5a neutralization was tested using the fusion protein as vaccine in three different arthritis mouse models: collagen induced arthritis (CI

Background and purpose - Little is known about the comparative performance of patient-reported outcome measures in revision hip arthroplasty. We compared the performance of the WOMAC, the SF-36, the EQ-5D, and a pain-related visual analog scale (VAS) in revision hip arthroplasty. Methods - 45 patients with aseptic prosthetic loosening following primary hip arthroplasty completed the WOMAC, the SF-

After oesophageal cancer surgery it is known that patients have a reduced QOL and that they suffer an unmet need of support. The overall aim of this thesis was to investigate patients’ experiences of QOL and supportive care as well as to evaluate a telephone based nurse-led supportive care programme to patients after oesophageal cancer surgery. The thesis comprises two quantitative (I, IV) and tw

The dinuclear complex [Zn2(papy)2]·2CH3OH [H2papy = N- (2-hydroxybenzyl)-N-(2-picolyl)glycine] was synthesized and characterized. The crystal structure of the complex reveals that both ZnII ions are pentacoordinate with distorted pentagonal bipyramidal coordination arrangements. The phenoxyl groups of each ligand bridge the two metal atoms, whereas each carboxylate of the ligand is terminally boun

In this Note we present a complete solution to the problem of multifractal analysis of multiple ergodic averages in the case of symbolic dynamics for functions of two variables depending on the first coordinate. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Objective In contrast with the wealth of data on ischaemic heart disease in rheumatoid arthritis (RA), data on stroke are scarce and contradictory. Despite the high clinical and aetiological relevance, there is no data regarding when (if ever) after RA diagnosis there is an increased risk. Our objective was to assess the risk of stroke (by subtype) in contemporary patients with RA, particularly in

Objective . Intestinal ischaemia is a life-threatening condition with high mortality, and the lack of accurate and readily available diagnostic methods often results in delay in diagnosis and treatment. The aim of this study was to investigate the accuracy of different plasma biomarkers in diagnosing intestinal ischaemia. Material and methods . Prospective inclusion of patients older than 50 years

Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcoho

Purpose: About half of all people with disabilities in developing countries live in extreme poverty. Focusing on the ends rather than the economic means of human development, the capability approach offers an alternative view of poverty. The purpose of this study was to explore the relation between assistive technology use and capability poverty in a low-income country. Method: Self-reported data

To assess whether recently discovered genetic loci associated with hyperglycemia also predict long-term changes in glycemic traits. Methods: Sixteen fasting glucose-raising loci were genotyped in middle-aged adults from the GLACIER Study, a population-based prospective cohort study from Northern Sweden. Genotypes were tested for association with baseline fasting and 2-hr post-challenge glycemia (N

This work introduces a novel approach to the detection of brief episodes of paroxysmal atrial fibrillation (PAF). The proposed detector is based on four parameters which characterize RR interval irregularity, P-wave absence, f-wave presence, and noise level, of which the latter three are determined from a signal produced by an echo state network. The parameters are used for fuzzy logic classificat

Background: In 2007 the World Cancer Research Fund Report concluded that there was limited and inconsistent evidence for an effect of coffee and tea consumption on the risk of epithelial ovarian cancer (EOC). Objective: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we aimed to investigate whether coffee intakes, tea intakes, or both are associated with the risk of EOC

Ultrafast photoinduced electron transfer preceding energy equilibration still poses many experimental and conceptual challenges to the optimization of photoconversion since an atomic-scale description has so far been beyond reach. Here we combine femtosecond transient optical absorption spectroscopy with ultrafast X-ray emission spectroscopy and diffuse X-ray scattering at the SACLA facility to tr

We investigate experimentally and numerically the nonlinear propagation of intense BesselGauss vortices in transparent solids. We show that nonlinear Bessel-Gauss vortices preserve all properties of nonlinear Bessel-Gauss beams while their helicity provides an additional control parameter for single-shot precision micro structuring of transparent solids. For sufficiently large cone angle, a stable

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Målet med denna avhandling var att undersöka hur cancersjukdomar i barndomen och behandlingen av dessa påverkar olika aspekter av fortplantningsförmågan i vuxen ålder. Glädjande nog har andelen patienter som överlever cancer i barndomen de senaste decennierna ökat stadigt till nivåer som idag ligger på nästan 80%. Ökad överlevnad medfChildhood cancer (CC) survival rate has increased over the last couple of decades, today approaching 80%. Therefore more attention has been paid to late effects. One important issue for CC survivors (CCS) is impaired reproductive function. CC per se and/or its treatment can impair the reproductive ability by affecting sperm production, as well as by damaging sperm DNA. This is a matter of concern,

Industrial Saccharomyces cerevisiae strains able to utilize xylose have been constructed by overexpression of XYL1 and XYL2 genes encoding the NADPH-preferring xylose reductase (XR) and the NAD(+)-dependent xylitol dehydrogenase (XDH), respectively, from Pichia stipitis. However, the use of different co-factors by XR and XDH leads to NAD(+) deficiency followed by xylitol excretion and reduced prod

Colloidal dispersions of anisometric particles can display dynamical arrest and ordering involving both translational and rotational degrees of freedom. We show that orientational order can develop in glassy colloidal dispersions of charged platelets when a concentration gradient is imposed through solvent evaporation. Our model system of Laponite (LRD) platelets in deionized water has been extens

The purpose of the paper is to: i) explore how the ownership-relationship between the public authority and the provider of the service is organized and managed to secure accountability in those cases the ownership remains public ii) how the purchaser-provider relationship is organized and managed so that public value are protected and iii) to what extent NPM still influences the reforms conducted

We report low-temperature transport studies of parallel double quantum dots formed in GaSb/InAsSb core-shell nanowires. At negative gate voltages, regular patterns of Coulomb diamonds are observed in the charge stability diagrams, which we ascribe to single-hole tunneling through a quantum dot in the GaSb core. As the gate voltage increases, the measured charge stability diagram indicates the appe