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Low Serum Levels of Dehydroepiandrosterone Sulfate Predict All-Cause and Cardiovascular Mortality in Elderly Swedish Men.

Context: The age-related decline in dehydroepiandrosterone (DHEA) levels is thought to be of importance for general and vascular aging. However, data on the association between DHEA and mortality are conflicting. Objectives: We tested the hypothesis that low serum DHEA and DHEA sulfate (DHEA-S) levels predict all-cause and cardiovascular disease (CVD) death in elderly men. Design, Setting, and Par

Exploring the Duration of EU Imports

The objective of this paper is to perform an empirical description and analysis of the duration of EU imports from the rest of the world. Toward this aim, we employ a rich data set of detailed imports to individual EU15 countries from 140 non-EU exporters, covering the period 1962-2006. Using these data, we both perform a thorough descriptive analysis of the duration of EU trade, and test the data

Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.

The main function of CAs (carbonic anhydrases) is to participate in the regulation of acid-base balance. Although 12 active isoenzymes of this family had already been described, analyses of genomic databases suggested that there still exists another isoenzyme, CA XV. Sequence analyses were performed to identify those species that are likely to have an active form of this enzyme. Eight species had

Software Quality Alignment:Evaluation and Understanding

Abstract in UndeterminedBackground: The software development environment is growing increasingly complex, with a greater diversity of stakeholders involved in product development. Moves towards global software development with onshoring, offshoring, insourcing and outsourcing have seen a range of stakeholders introduced to the software development process, each with their own incentives and unders

On the complexity of resilient network design

In this article we prove NP-hardness of two well-known optimization problems related to the design of multicommodity flow networks with two different methods for providing network resiliency against failures: path diversity and flow restoration. Path diversity is a static mechanism that consists of using, for each demand, a number of paths and oversizing the flows assigned to these paths so that f

Critical role of p38 mitogen-activated protein kinase signaling in septic lung injury.

OBJECTIVE: Leukocyte-mediated tissue damage is a key feature in septic lung injury, although the signaling mechanisms behind pulmonary recruitment of leukocytes remain elusive. The aim of the present study was to define the role of p38 mitogen-activated protein kinase (MAPK) signaling in septic lung injury. DESIGN: Prospective experimental study. SETTING: University hospital research unit. SUBJECT

Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2).

Mutations in the gene encoding glucokinase (GCK) cause a mild hereditary form of diabetes termed maturity-onset diabetes of the young (MODY)2 or GCK-MODY. The disease does not progress over time, and diabetes complications rarely develop. It has therefore been suggested that GCK-MODY represents a metabolically compensated condition, but experimental support for this notion is lacking. Here, we pro

Robot-assisted laparoscopic myomectomy; a feasible technique for removal of unfavorably localized myomas.

Objective. To describe the feasibility of robot-assisted laparoscopic myomectomy for unfavorably localized myomas using the da Vinci surgical system. Design. Prospective observational. Setting. University hospital. Method. Between April 2006 and March 2008, a robot-assisted laparoscopic myomectomy was performed on 13 women selected for having deep intramural myomas with probable impact on fertilit

2002 års män och kvinnor : medborgare rapporterar om hemlöshet

In 2002 a group of men and women, coming from different professions but sharing an interest in social issues, joined together in a Citizens' Study (medborgarundersökning) in the Swedish city of Malmö. They were inspired by a classic Swedish citizens' study "Men of 1912" (1912 års män) which was a clandestine field study of the deplorable conditions in Stockholm's hostels in 1912. This book is a co

Cerebral Blood Flow Alterations in Pain-Processing Regions of Patients with Fibromyalgia Using Perfusion MR Imaging.

BACKGROUND AND PURPOSE: Widespread pain sensitivity in patients with FM suggests a CNS processing problem. The purpose of this study was to assess alterations in perfusion as measured by DSC in a number of brain regions implicated in pain processing between patients with FM and healthy controls. MATERIALS AND METHODS: Twenty-one patients with FM and 27 healthy controls underwent conventional MR i