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Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study

Background: This international study aimed to characterise the impact of acute SARS-CoV-2 infection in people with cystic fibrosis and investigate factors associated with severe outcomes. Methods Data from 22 countries prior to 13th December 2020 and the introduction of vaccines were included. It was de-identified and included patient demographics, clinical characteristics, treatments, outcomes an

Gender Equal Citizenship and Ethno-National Conflict : Women's Political Activism and Public Participation During the Northern Irish Troubles

This paper provides a theoretical synthesis of three research areas – gender, nationalism and citizenship – by linking together the gendered discourses of ethno-nationalism and citizenship. It explores the potential for building a gender equal citizenship in societies divided by ethno-national conflict. More specifically, it analyzes women’s activism and participation in public and political life

Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial

Importance: Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control is a clinically important therapeutic goal of surgical intervention, including nodal surgery. Objective: To determine how frequently SLN biopsy without completion lymph node dissection (CLND) results in long-term regional nodal disease control in patients with SLN metastase

Rare genetic variants explain missing heritability in smoking

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this ‘missing heritability’. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four

Nonlinear Optics Studies on the MAX IV Storage Rings

The MAX IV Laboratory in Lund, Sweden, houses two electron storage rings operating at the energies 1.5, and 3 GeV. Both of these produce high-brilliance synchrotron radiation for beamline users. While the 1.5 GeV storage ring is a conventional third generation storage ring, employing a double-bend achromat structure, the MAX IV 3 GeV ring is the first realised fourth generation synchrotron. This r

Toward Effective Collaborations between Regional Climate Modeling and Impacts-Relevant Modeling Studies in Polar Regions

The aim of this workshop was to discuss the needs and challenges in using high-resolution climate model outputs for impacts-relevant modeling. Development of impacts-relevant climate projections in the polar regions requires effective collaboration between regional climate modelers and impacts-relevant modelers in the design stage of high-resolution climate projections for the polar regions.

Design and implementation of the European-Mediterranean Postgraduate Programme on Organ Donation and Transplantation (EMPODaT) for Middle East/North Africa countries

This prospective study reports the design and results obtained after the EMPODaT project implementation. This project was funded by the Tempus programme of the European Commission with the objective to implement a common postgraduate programme on organ donation and transplantation (ODT) in six selected universities from Middle East/North Africa (MENA) countries (Egypt, Lebanon and Morocco). The co

Core-shell excitation of isoxazole at the C, N, and O K-edges - an experimental NEXAFS and theoretical TD-DFT study

The near-edge X-ray absorption fine structure (NEXAFS) spectra of the gas-phase isoxazole molecule have been measured by collecting total ion yields at the C, N, and O K-edges. The spectral structures have been interpreted using time-dependent density functional theory (TD-DFT) with the short-range corrected SRC2-BLYP exchange-correlation functional. Experimental and calculated energies of core ex

Measuring Inflation Expectations in Interwar Britain

What caused the recovery from the British Great Depression? A leading explanation – the ‘expectations channel’ – suggests that a shift in expected inflation lowered real interest rates and stimulated consumption and investment. However, few studies have measured, or tested the economic consequences of, inflation expectations. In this paper, we collect high-frequency information from primary and se

α-Synuclein-induced deformation of small unilamellar vesicles

Abstract α-Synuclein is a small neuronal protein that reversibly associates with lipid membranes. The membrane interactions are believed to be central to the healthy function of this protein involved in synaptic plasticity and neurotransmitter release. α-Synuclein has been speculated to induce vesicle fusion as well as fission, processes which are analogous to each other but proceed in different d