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Tiling array-CGH for the assessment of genomic similarities among synchronous unilateral and bilateral invasive breast cancer tumor pairs.

ABSTRACT: BACKGROUND: Today, no objective criteria exist to differentiate between individual primary tumors and intra- or intermammary dissemination respectively, in patients diagnosed with two or more synchronous breast cancers. To elucidate whether these tumors most likely arise through clonal expansion, or whether they represent individual primary tumors is of tumor biological interest and may

Användning av arabisk skönlitteratur i modersmålsundervisningen

Denna artikel bygger på en dubbelföreläsning vid LMS språkdagar den 3 april 2011 på Högskolan i Halmstad. Målgruppen var 20 modersmålslärare i arabiska. Efter en historisk översikt av den moderna arabiska litteraturen under de senaste tvåhundra åren tog jag upp utvecklingen av den arabiska romanen från Zaynab: Lantliga scener och sedvänjor (1913) av den egyptiske författaren Muhammad Husayn Haykal

Exact and approximation algorithms for graph problems with some biological applications

In this thesis we study several combinatorial problems in algorithmic graph theory and computational biology, and different algorithmical approaches for solving them. In particular, we focus on graph algorithms, seeking for the most part polynomial or sub-exponential exact solutions, but in some cases also approximate solutions. In the first part we study two problems on phylogenetic trees, the pr

Conditional Partial Plans for Rational Situated Agents Capable of Deductive Reasoning and Inductive Learning

Rational, autonomous agents that are able to achieve their goals in dynamic, partially observable environments are the ultimate dream of Artificial Intelligence research since its beginning. The goal of this PhD thesis is to propose, develop and evaluate a framework well suited for creating intelligent agents that would be able to learn from experience, thus becoming more efficient at solving thei

Environmental and biological monitoring of antineoplastic drugs in four workplaces in a Swedish hospital.

OBJECTIVES: Exposure to antineoplastic drugs should be avoided due to the risk of getting adverse health effects. Antineoplastic drugs such as cyclophosphamide (CP) and ifosfamide (IF) are commonly used in medical attendance. In this study the variability of surface contamination of CP and IF was investigated by repeated wipe sampling over time in four workplaces in a university hospital. The surf

Effects of 24-hour and 36-hour sleep deprivation on smooth pursuit and saccadic eye movements.

Sleep restrictions and sleep deprivation have become common in modern society, as many people report daily sleep below the recommended 8 hours per night. This study aimed to examine the effects of sleep deprivation on oculomotor performance by recording smooth pursuit and saccadic eye movements after 24 and 36 hours of sleep deprivation. Another objective was to determine whether detected changes

Process Design for Ultrafiltration of Complex Process Streams

Considerable effort has been dedicated over the years to model and simulate the ultrafiltration process. Most approaches are theoretical and therefore not applicable to industrial process streams. When treating such solutions, a combination of experiments and simulations is needed. In this thesis, a method has been developed for design and optimization of UF plants. The method uses experiments in

The ABO blood group system revisited: a review and update.

The antigens of the ABO system were the first to be recognized as blood groups and actually the first human genetic markers known. Their presence and the realization of naturally occurring antibodies to those antigens lacking from the cells made sense of the erratic failure of blood transfusion hitherto and opened up the possibility of a safe treatment practice in life-threatening blood loss. Alth

Use of pediatric Berlin Heart EXCOR biventricular device as a bridge to retransplantation in a 10-month-old infant with acute graft failure after cardiac transplantation.

We report the implantation of the Berlin Heart EXCOR (Berlin Heart, Berlin, Germany) as a pediatric biventricular assist device in a 10-month-old boy with primary graft failure after cardiac transplantation. The EXCOR was successfully used as a bridge to cardiac retransplantation. The pneumatically driven paracorporeal device supported the patient for 165 days until another suitable heart was obta

Early treatment response evaluated by a clinical scoring system correlates with the prognosis of pulmonary tuberculosis patients in Ethiopia: A prospective follow-up study.

Background: In resource-limited settings the monitoring of tuberculosis (TB) patients is challenging, and early identification of TB patients with a high mortality risk is important. The aim of this study was to investigate prospectively whether early changes in a clinical scoring system (TB score) can predict treatment outcome in Ethiopian patients with pulmonary tuberculosis. Method: TB patients

A computational model for understanding stem cell, trophectoderm and endoderm lineage determination

Background. Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties -- self renewal and pluripotency. In addition, mutual antagonism between two of these and other master regulators have been shown to regulate lineage determination. In particular, an excess of Cdx2 over

Hospitalisation of and mortality from bleeding peptic ulcer in Sweden: a nationwide time-trend analysis.

Aliment Pharmacol Ther 2011; 33: 578-584 SUMMARY: Background Time-trend analyses of incidence and mortality in bleeding peptic ulcer show divergent results. Aim To conduct a detailed national analysis of hospitalisation of and mortality from bleeding peptic ulcer in Sweden. Method Data from all hospitalisations at departments with primary responsibility for patients with bleeding ulcer in Sweden,