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Modelling and computational improvements to the simulation of single vector-boson plus jet processes for the ATLAS experiment

This paper presents updated Monte Carlo configurations used to model the production of single electroweak vector bosons (W, Z/γ∗) in association with jets in proton-proton collisions for the ATLAS experiment at the Large Hadron Collider. Improvements pertaining to the electroweak input scheme, parton-shower splitting kernels and scale-setting scheme are shown for multi-jet merged configurations ac

Study of Bc+→J/ψDs+ and Bc+→J/ψDs∗+ decays in pp collisions at √s = 13 TeV with the ATLAS detector

A study of Bc+→J/ψDs+ and Bc+→J/ψDs∗+ decays using 139 fb−1 of integrated luminosity collected with the ATLAS detector from s = 13 TeV pp collisions at the LHC is presented. The ratios of the branching fractions of the two decays to the branching fraction of the Bc+→ J/ψπ+ decay are measured: B(Bc+→J/ψDs+)/B(Bc+→J/ψπ+) = 2.76 ± 0.47 and B(Bc+→J/ψDs∗+)/B(Bc+→J/ψπ+) = 5.33 ± 0.96. The ratio of the b

Measurements of the Higgs boson inclusive and differential fiducial cross-sections in the diphoton decay channel with pp collisions at √s = 13 TeV with the ATLAS detector

A measurement of inclusive and differential fiducial cross-sections for the production of the Higgs boson decaying into two photons is performed using 139 fb−1 of proton-proton collision data recorded at s = 13 TeV by the ATLAS experiment at the Large Hadron Collider. The inclusive cross-section times branching ratio, in a fiducial region closely matching the experimental selection, is measured to

KS0KS0 and KS0K± femtoscopy in pp collisions at s=5.02 and 13 TeV

Femtoscopic correlations with the particle pair combinations KS0KS0 and KS0K± are studied in pp collisions at s=5.02 and 13 TeV by the ALICE experiment. At both energies, boson source parameters are extracted for both pair combinations, by fitting models based on Gaussian size distributions of the sources, to the measured two-particle correlation functions. The interaction model used for the KS0KS

Deep Learning for Modelling of Urban Drainage Networks: A Physics-informed Surrogate Model Using Measured and Simulated Data

City-wide climate adaptation for pluvial flood mitigation requires fast and reliable simulation tools. Considering the limitations of hydrodynamic models at city-scale simulations, data driven models have high potential in the development of surrogate tools. This study explores the Google DeepMind WaveNet™ model architecture to map hydrological response of catchments onto hydraulic parameters of t

Experience of a systematic approach to care and prevention of fragility fractures in New Zealand

Summary: This narrative review describes efforts to improve the care and prevention of fragility fractures in New Zealand from 2012 to 2022. This includes development of clinical standards and registries to benchmark provision of care, and public awareness campaigns to promote a life-course approach to bone health. Purpose: This review describes the development and implementation of a systematic a

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 non-Europeans) from the UK, Sweden and Mexico, we identify 16 genes associated with fat distribution at exome-wide significance. We show 6-fold larger effect for fat-distribution associated rare coding variants compa

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Missense mutations in MORC2 cause neuropathies including spinal muscular atrophy and Charcot-Marie-Tooth disease. We recently identified MORC2 as an effector of epigenetic silencing by the human silencing hub (HUSH). Here we report the biochemical and cellular activities of MORC2 variants, alongside crystal structures of wild-type and neuropathic forms of a human MORC2 fragment comprising the GHKL

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2

Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR-Cas9-mediated forward genetic screen, we identified MORC2 as an essential gene required for epigenetic silencing by the HUSH complex. HUSH recruits MORC2 to target sites in heterochromatin. We ex

Lay Health Promoters Empower Neighbourhoods : Results From a Community-Based Research Programme in Southern Sweden

This article focuses on the role of lay health promoters in the Lindängen initiative, a community-based participatory research (CBPR) programme for health promotion that started 2016 in a low-income neighbourhood in the outskirts of Malmö, southern Sweden. The programme aimed to support equitable health and develop an innovative model for community health promotion. The purpose of this article is

Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence from the COURAGE-PD Consortium

Background and Objectives Considerable heterogeneity exists in the literature concerning genetic determinants of the age at onset (AAO) of Parkinson disease (PD), which could be attributed to a lack of well-powered replication cohorts. The previous largest genome-wide association studies (GWAS) identified SNCA and TMEM175 loci on chromosome (Chr) 4 with a significant influence on the AAO of PD; th

Future-Oriented Methodologies for Sustainability

Both in the social and natural sciences, methodologies have been developed to deal with relatively stable conditions, where findings can be validated based on past experiences. At a time when both social and natural phenomena are rapidly changing, new approaches are urgently needed to produce knowledge for systemic change, inform high-stakes decisions, and enable sustainability transitions in the

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi

Vertebral Hemangiomas : Prevalence, New Classification and Natural History. Magnetic Resonance Imaging-Based Retrospective Longitudinal Study

Background and purpose: To determine the prevalence of vertebral hemangiomas (VHs), establish a new classification of VHs based on their MRI-signal pattern, and study their natural history. Methods: MRI of 1000 consecutive patients who underwent at least two MRI with an interval of at least 3 years. Growth rate and change of MRI-signal pattern during the follow-up period were the parameters includ

Education of Refugees

The educational opportunities of refugee learners are shaped by forces of globalization, restrictive mobility regimes and geopolitical agendas, that place them in a position of structural disadvantage. The majority of the world's refugee learners have fled due to armed conflict and reside in neighboring countries in the global South. In many cases forced displacement is protracted, with limited gl

Negotiations of step-grandparenting

Almost half of all divorced Swedes today are aged 60+ and many of them are, or have been, a part of a reconstituted family (Bildtgård & Öberg 2014). This means that the probability of having step-grandchildren increases in a life cycle perspective. For those who have never had neither children nor stepchildren, a sibling's or a friend's grandchild can have the same meaning as a step-grandchildAlmost half of all divorced Swedes today are aged 60+ and many of them are, or have been, a part of a reconstituted family (Bildtgård & Öberg 2014). This means that the probability of having step-grandchildren increases in a life cycle perspective. For those who have never had neither children nor stepchildren, a sibling's or a friend's grandchild can have the same meaning as a step-grandchild

Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study

Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of termin

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to po

Acute postoperative endophthalmitis : Microbiology from the laboratory to the bedside

Postoperative endophthalmitis is a dreaded complication of intraocular surgery. Acute presentations need prompt management and good knowledge of differential diagnoses. In the last 10 years, progress in direct microbial detection and identification from intraocular samples included the use of blood culture systems and, more recently, matrix-assisted laser desorption ionization time-of-flight mass