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Association of plasma Vitamin D metabolites with incident type 2 diabetes : EPIC-InterAct case-cohort study

Background: Existing evidence for the prospective association of vitamin D status with type 2 diabetes (T2D) is focused almost exclusively on circulating total 25-hydroxyvitamin D [25(OH)D] without distinction between its subtypes: Nonepimeric and epimeric 25(OH)D 3 stereoisomers, and 25(OH)D 2 , the minor component of 25(OH)D. We aimed to investigate the prospective associations of circulating

Measurement of the top quark mass in the tt¯ → lepton+jets channel from √s=8 TeV ATLAS data and combination with previous results

The top quark mass is measured using a template method in the tt¯ → lepton + jets channel (lepton is e or μ) using ATLAS data recorded in 2012 at the LHC. The data were taken at a proton–proton centre-of-mass energy of s=8 TeV and correspond to an integrated luminosity of 20.2 fb - 1 . The tt¯ → lepton + jets channel is characterized by the presence of a charged lepton, a neutrino and four jets, t

Fast 4‐D Imaging of Fluid Flow in Rock by High‐Speed Neutron Tomography

High‐speed neutron tomographies (1‐min acquisition) have been acquired during water invasion into air‐filled samples of both intact and deformed (ex situ) Vosges sandstone. Three‐dimensional volume images have been processed to detect and track the evolution of the waterfront and to calculate full‐field measurement of its speed of advance. The flow process correlates well with known rock propertie

Investigating Mode Switch from SI to HCCI using Early Intake Valve Closing and Negative Valve Overlap

This study investigates mode switching from spark ignited operation with early intake valve closing to residual gas enhanced HCCI using negative valve overlap on a port-fuel injected light-duty diesel engine. A mode switch is demonstrated at 3.5 bar IMEPnet and 1500 rpm. Valve timings and fuel amount have to be selected carefully prior to the mode switch. During mode transition, IMEPnet deviates b

Measurement of the four-lepton invariant mass spectrum in 13 TeV proton-proton collisions with the ATLAS detector

A measurement of the four-lepton invariant mass spectrum is made with the ATLAS detector, using an integrated luminosity of 36.1 fb −1 of proton-proton collisions at s = 13 TeV delivered by the Large Hadron Collider. The differential cross-section is measured for events containing two same-flavour opposite-sign lepton pairs. It exhibits a rich structure, with different mass regions dominated in th

Novel monogalactoside galectin inhibitor scaffolds : Guiding selectivity with heteroaromatic interactions

Carbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the abCarbohydrates are involved in many cellular processes, and most biomolecules are glycosylated. Thesemodifications are used in biological systems as information carriers, helping regulate organization on the cell surfaceand interactions between cells and the environment. Galectins are a family of carbohydrate binding proteins thatbind to polysaccharides containing a galactose. Galectins have the ab

Extracorporeal Arteriovenous Ultrasound Measurement of Cardiac Output in Small Children

WHAT WE ALREADY KNOW ABOUT THIS TOPIC: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Technology for cardiac output (CO) and blood volume measurements has been developed based on blood dilution with a small bolus of physiologic body temperature saline, which, after transcardiopulmonary mixing, is detected with ultrasound sensors attached to an extracorporeal arteriovenous loop using existing

Measurements of inclusive and differential fiducial cross-sections of tt¯ production with additional heavy-flavour jets in proton-proton collisions at √s = 13 TeV with the ATLAS detector

This paper presents measurements of tt¯ production in association with additional b-jets in pp collisions at the LHC at a centre-of-mass energy of 13 TeV. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb −1 . Fiducial cross-section measurements are performed in the dilepton and lepton-plus-jets tt¯ decay channels. Results are presented at particl

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci assoc

Charged-particle pseudorapidity density at mid-rapidity in p–Pb collisions at √sNN = 8.16 TeV

The pseudorapidity density of charged particles, d N ch / d η, in p–Pb collisions has been measured at a centre-of-mass energy per nucleon–nucleon pair of sNN = 8.16 TeV at mid-pseudorapidity for non-single-diffractive events. The results cover 3.6 units of pseudorapidity, | η| < 1.8. The d N ch / d η value is 19.1 ± 0.7 at | η| < 0.5. This quantity divided by ⟨ N part ⟩ / 2 is 4.73 ± 0.20 , where

Remote Supervision of an Unmanned Surface Vessel - a Comparison of Interfaces

We compared three different Graphical User Interfaces (GUI) that we have designed and implemented to enable human supervision of an unmanned ship. Our findings indicate that a 3D GUI presented either on a screen or in a Virtual Reality (VR) setting provides several objective and subjective benefits compared to a Baseline GUI representing traditional tools.

Climate control on alluvial sediment storage in the northern foreland of the Tatra Mountains since the late Pleistocene

Numerical dating and geomorphic studies on alluvial sediment were undertaken in the uppermost reaches of the Dunajec River catchment in the northern foreland of the Tatra Mountains of Poland. Successions of alluvial deposits in river terraces and alluvial fans are common in this region. In particular, alluvial fans deposited a thick succession of sediment in the intramontane Orawa-Nowy Targ Depres

Lake-level variability in Salar de Coipasa, Bolivia during the past ∼40,000 yr

Various paleoclimatic records have been used to reconstruct the hydrologic history of the Altiplano, relating this history to past variability of the South American summer monsoon. Prior studies of the southern Altiplano, the location of the world's largest salt flat, the Salar de Uyuni, and its neighbor, the Salar de Coipasa, generally agree in their reconstructions of the climate history of the

Comprehensive echocardiographic imaging of atrioventricular valves in children with atrioventricular septal defect : Accuracy of 2D and 3D imaging and reasons for disagreement

OBJECTIVE: To compare the accuracy and reasons for disagreement of two-dimensional (2D) and three-dimensional (3D) echocardiography findings in the assessment of the atrioventricular valve complex in patients with atrioventricular septal defect. METHODS: A total of 20 children (mean age 8 months) with atrioventricular septal defect were enrolled prospectively into this study. The accuracy of and t

Non-binary phase gratings for x-ray imaging with a compact Talbot interferometer

X-ray imaging using a Talbot-Lau interferometer, consisting of three binary gratings, is a well-established approach to acquire x-ray phase-contrast and dark-field images with a polychromatic source. However, challenges in the production of high aspect ratio gratings limit the construction of a compact setup for high x-ray energies. In this study we consider the use of phase gratings with triangul