Archaeological 3D GIS provides archaeologists with a guide to explore and understand the unprecedented opportunities for collecting, visualising and analysing archaeological datasets in three dimensions.With platforms allowing archaeologists to link, query and analyse in a virtual, georeferenced space information collected by different specialists, the book highlights how it is possible to re-thin

Experimentally determined vitamin degradation kinetic parameters are vital input for process optimization, e.g., of nutrient rich beverages such as milk and fruit juices. The standard method of obtaining these parameters is to subject a test-tube of the nutrient (in its food matrix) to a water bath at elevated temperatures and measure remaining concentration as a function of time. It is well known

Objective: We describe real-world evidence (RWE) from the nationwide Swedish and Danish registries that provide important information on incidence and outcome in multiple myeloma (MM). Method: First line treatment data on more than 10.000 MM patients from Denmark and Sweden between 2005–2018 are presented. Key results from research conducted within the Swedish and Danish myeloma registries are sum

Under 1980-talet började flera svenska kommuner etablera en sekundär bostadsmarknad, där socialtjänsten hyrde ut lägenheter i andra hand till hemlösa klienter som var utestängda från den ordinarie bostadsmarknaden. Orsaken var en kombination av fastighetsägares ”höga trösklar”, socialtjänstens behov av boenden för hemlösa klienter och båda parters strävan efter kontroll. Möjligheten att tilldelas

Many research studies have been done to investigate different aspects of environmental challenges. In the product development context, there have been attempts to reduce the environmental impacts of associated activities including the production processes themselves. As a result, various technological improvements have been made and new production processes e.g. powder metallurgy technologies have

The aim of this work is to perform molecular dynamic simulations of nanometric cutting on single crystal copper with a diamond tool in orderto investigate the dependence of crystallographic orientation and cutting speeds on the cutting forces, machined surface and temperature. It wasfound that the temperature in the substrate, locally and globally, increased for increasing velocity. A higher degre

When small and hollow components are being manufactured, it is not uncommon that a majority of the workpiece material is removed by machining. A demand for parts made with lead-free brass alloys can potentially increase the manufacturing cost and therefore it is necessary to investigate ways to increase the material utilization. As part of a more resource efficient production, a method for reusing

This study develops the method for solution of inverse heat conduction problem applied to metal cutting. The proposed method operates with a selection procedure involving iterative solutions of heat forward problem. In such formulation, it allows avoiding difficulties associated with ill-posed inverse problems inherent to conventional formulations. Inverse heat problem was transformed into constra

The Caenorhabditis elegans germline is widely used as a model to study stem cell development, chromosome dynamics and apoptosis. Major readouts of germline phenotypes such as cell counting and protein expression profiling are routinely analyzed manually and in a two-dimensional manner. The major disadvantages of the existing approaches are 1) they are time-consuming and laborious and 2) there is a

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assemble

Transmembrane heparan sulfate proteoglycans regulate multiple aspects of cell behavior, but the molecular basis of their signaling is unresolved. The major family of transmembrane proteoglycans is the syndecans, present in virtually all nucleated cells, but with mostly unknown functions. Here, we show that syndecans regulate transient receptor potential canonical (TRPCs) channels to control cytoso

A new tribotester has been developed to characterize the friction conditions in sheet metal forming applications. The basic principle for the tribotester is parallel strip drawing. This apparatus is an improvement on conventional test setups in that it offers controllable speed and normal load during experimenting, a tool size that is variable over a wide range, and direct force measurement to all

Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival

In the 25 years, as the first of the syndecan family was cloned, interest in these transmembrane proteoglycans has steadily increased. While four distinct members are present in mammals, one is present in invertebrates, including C. elegans that is such a powerful genetic model. The syndecans, therefore, have a long evolutionary history, indicative of important roles. However, these roles have bee

Fibroblasts null for the transmembrane proteoglycan, syndecan-4, have an altered actin cytoskeleton, compared with matching wild-type cells. They do not organize alpha-smooth muscle actin into bundles, but will do so when full-length syndecan-4 is re-expressed. This requires the central V region of the core protein cytoplasmic domain, though not interactions with PDZ proteins. A second key require

Syndecans are type I transmembrane proteins having a core protein modified with glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of molecules, present in invertebrates and vertebrates. Among the plethora of molecules that can interact with heparan sulphate, the collagens and glycoproteins of the extracellular matrix are prominent. Frequently, they do so in conjun

This paper addresses the quantification of the value of structural health monitoring (SHM) before its implementation for structural systems on the basis of its Value of Information (VoI). The value of SHM is calculated utilizing the Bayesian pre-posterior decision analysis modelling the structural life cycle performance, the integrity management and the structural risks. The relevance and precisio

Manganese oxides occur in a wide range of environmental settings either as coatings on rocks, sediment, and soil particles, or as discrete grains. Although the production of biologically mediated Mn oxides is well established, relatively little is known about microbial-specific strategies for utilizing Mn in the environment and how these affect the morphology, structure, and chemistry of associate