Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-scale resources. Here we explore the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glycemic trai

Inclusive and differential cross-sections for the production of top quarks in association with a photon are measured with proton-proton collision data corresponding to an integrated luminosity of 139 fb−1. The data were collected by the ATLAS detector at the LHC during Run 2 between 2015 and 2018 at a centre-of-mass energy of 13 TeV. The measurements are performed in a fiducial volume defined at p

Smart cyber-physical systems (S-CPSs) are complex engineered systems empowered by cyber-physical computing and equipped with the capability of reasoning, learning, adapting, and evolving. As an outcome of data-driven dynamic computing, reasoning capabilities, and the run-time obtained own knowledge, nonlinear and emergent behavior of S-CPSs whilst in operation is an open issue, not experienced in

The presented work is focused on the development of a comprehensive thermo-mechanical model for predicting the temperature rise in thermoplastic polymer spur gears with any desired profile geometry while running. The specific constitutional behavior of thermoplastics influences the gear-meshing pattern, which can deviate substantially from ideal gear meshing, as typically exhibited by metal gears

Generally, it is supposed that the Fermi level in epitaxial graphene is controlled by two effects: p-type polarization doping induced by the bulk of the hexagonal silicon carbide (SiC)(0001) substrate and overcompensation by donor-like states related to the buffer layer. The presented work is evidence that this effect is also related to the specific underlying SiC terrace. Here a periodic sequence

Argumentationsteorin i dissertationen Paulus argumentation i Galaterbrevet: en pragma-dialektisk analys.

As water in a rainwater regulating reservoir at the Sankyo landfill site in Nagasaki City tends to be alkalized and to exceed the pH upper limit of 7.5, measures to suppress the alkalization should be implemented. Inhibiting photosynthesis in algae is required to suppress the alkalization. Shading is one of the methods for inhibiting algal photosynthesis. In this study, we evaluated the pH reducti

In advective-dispersive simulations of aquifers, retardation factors using linear adsorption isotherms are commonly employed to represent the adsorption-desorption process for solutes in soil. In particular, the retardation factors that use entire pore space (total porosity) or effective pore space (effective porosity) are widely used. Although another retardation factor that describes solute tran

Energy communities are emphasized by the EU as important for developing sustainable energy systems that include and engage many people. While many renewables are highly compatible with a more decentralized energy system, research indicates that participation in 'desirable' energy activities and energy decision-making is influenced by social and economic factors, including gender, economic status a

Synaptic changes and neuronal network dysfunction are among the earliest changes in Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has been shown to be present at synapses and to induce hyperexcitability in mouse knock-in brain regions vulnerable to AD. ApoE in the brain is mainly generated by astrocytes, however, neurons can also produce ApoE under stres

An electronic device requires valid control keys to change any usage restriction setting. The device is provided control keys, a secret key, and a signed software object including a batch ID and a hash of the secret key. For each control key, the device generates a cryptographic footprint bound to the device and the secret key. A message authentication code (MAC) of each usage restriction setting

A method of protecting an electronic device from unauthorized reprogramming, the electronic device comprising a data memory and a key memory, the method comprising loading into the key memory a predetermined public key of a cryptographic public key mechanism for verifying subsequent data items to be loaded into the data memory, the subsequent data items being signed with a corresponding private ke

Dwarf birch (Betula nana L.), a dominant deciduous dwarf shrub in many tundra ecosystems, is predicted to increase substantially in abundance due to climate warming. Potential warming-induced changes in the concentrations of phenolic compounds in B. nana leaves could influence the susceptibility of B. nana to environmental stresses; however, only a few studies have investigated the effects of clim

Previous studies have offered strong evidence that grazers alter the vegetation composition and ecosystem carbon (C) balance in ecosystems. In Arctic peatlands, however, the role of grazing has remained largely uninvestigated. Falk et al (2015 Environ. Res. Lett. 10 045001) showed that grazing by muskoxen in a high Arctic mire significantly affected both the vegetation and release of greenhouse ga

Arctic tundra currently stores half of the global soil carbon (C) stock. Climate warming in the Arctic may lead to accelerated CO 2 release through enhanced decomposition and turn Arctic ecosystems from a net C sink into a net C source, if warming enhances decomposition more than plant photosynthesis. A large portion of the circumpolar Arctic is grazed by reindeer/caribou, and grazing causes impor

Archaeological 3D GIS provides archaeologists with a guide to explore and understand the unprecedented opportunities for collecting, visualising and analysing archaeological datasets in three dimensions.With platforms allowing archaeologists to link, query and analyse in a virtual, georeferenced space information collected by different specialists, the book highlights how it is possible to re-thin