RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key challenges with the development of new RNA-based t

Breast cancer is one of the most prevalent and diverse malignancies affecting women worldwide, with an estimated 2.3 million new cases globally in 2020 alone. In Sweden, breast cancer is a major societal issue with over 8600 new diagnoses and 1300 deaths per year. It presents significant challenges in diagnosis, treatment, and prognostication due to its complex biological, molecular, and clinical

The rapid expansion of the global solar photovoltaic (PV) market as part of the transition to a low-carbon energy future will increase both demand for raw materials used in PV product manufacturing as well as future PV panel waste volumes. There is an urgent need for solar industry businesses to adopt circular business models, and to support this process through targeted tools and methods that can

BACKGROUND/PURPOSE: Non-resuscitation fluids constitute the majority of fluid administered for septic shock patients in the intensive care unit (ICU). This multicentre, randomized, feasibility trial was conducted to test the hypothesis that a restrictive protocol targeting non-resuscitation fluids reduces the overall volume administered compared with usual care.METHODS: Adults with septic shock in

Introduction: The death of a parent can have profound negative impacts on children, and a lack of adequate support can exacerbate negative life experiences.Aim: To explore the influences of various actors on the content and execution of a bereavement programme within a Swedish context, considering relational and contextual perspectives.Methods: An ethnographic field study involving six children, t

Abstrakt Bakgrund: Ett övergripande mål inom förlossningsvården är att mor och barn ska må bra och att kvinnan ska få en positiv förlossningsupplevelse och en förlossning med så få interventioner som möjligt. Enligt kompetensbeskrivning för legitimerad barnmorska ska barnmorskan ha kompetens att bedöma förlossningens progress och identifiera avvikelser samt bedöma behov av vårdåtgärder. Det vanli

This study constructs a Sustainable Halal Tourism Composite Performance Index (SHTCPI) to evaluate the progress of the global halal tourism industry from a sustainable tourism perspective. To create the SHTCPI, this study uses four dimensions (environment, social, economic, and halal tourism) and 24 indicators covering the 2010 to 2020 period and 116 countries. The findings suggest that halal tour

Alternative fuels, such as natural and bio-gas, are attractive options for reducing greenhouse gas emissions from combustion engines. However, the naturally occurring variation in gas composition poses a challenge and may significantly impact engine performance. The gas composition affects fundamental fuel properties such as flame propagation speed and heat release rate. Deviations from the gas co

Background: Real-world data on health-related quality of life (HRQoL) in generalized pustular psoriasis (GPP) are scarce and studies have been restricted in terms of instruments used for assessments. Objective: To assess generic and dermatology-specific HRQoL of patients with GPP compared with patients with plaque psoriasis using real-world data from the Swedish National Register for Systemic Trea

The Kaunisvaara mining district, located in Norrbotten in northern Sweden, hosts several iron ore deposits, of which Tapuli and Sahavaara are the most economically important. The bedrock in the region has been subjected to several major deformation phases, which has created a complex structural pattern on a regional and local scale. Previous structural geological studies of the Tapuli deposit have

Integrating immigrants into the labor market is a challenge for the city of Malmö, impacting its performance to achieve Sustainable Development Goals related to Decent Jobs and Reduced Inequalities. This thesis explores the role of 3 social innovations in addressing this challenge, guided by the Multi-Level Perspective. The research explores unique approaches these enterprises apply to create empl

Freshwater demand is expected to rise while supplies decline, putting pressure on water systems. Water conservation and determining potential alternative sources is imperative. The thesis aims to determine the effectiveness of greywater recycling as an alternative source in Sweden. Sörsjön was used as a case study and the roles of property owners and water utilities explored. The theory of planned

Biodiversity loss and diminishing urban green space are widely recognized sustainability issues, but little research exists on the construction sector’s role and the attitudes they hold towards biodiversity. This study contributes to the sustainable urban design literature by studying how construction companies in Finland view their relation to biodiversity and how they could achieve better biodiv

To achieve established climate objectives, Sweden must effectively target its carbon-intensive steel industry. This study offers a social perspective on the Swedish steel industry's decarbonization, exploring how workers’ identities shape their experience of the transition. Social identity theory is utilised to explore what elements shape steelworkers’ collective and occupational identities in

The recognition of both inner (beliefs, mindsets, values) and outer dimensions (structures, technologies, behaviours) in addressing the climate crisis offers a powerful leverage point for the transformation needed. However, there is a lack of understanding of how this approach can be adapted to different groups and contexts. This thesis focuses on environmental activists from Russia as valuable ch

As one of the biggest coal producers in the EU and a country with a coal-based energy system, Poland is faced with a difficult challenge of transforming the energy sector. However, coal has a very powerful position in the country, protected by incumbent actors and their interests. This thesis focuses on the Bełchatów Basin, an important lignite region, and examines coal narratives and their implic

Bakgrund: Anestesisjuksköterskan ska bedriva en säker vård där ett personcentrerat förhållningssätt ska ligga till grund för patientmötet. Inom sjukvården är perifer venkatetersättning och intravenös kanylering bland de mest förekommande procedurerna. Dessutom förekommer stickprocedurer vid flertal andra interventioner som till exempel fosterdiagnostik och olika typer av vävnadsprover. Upp tilBackground: The anaesthesia nurse must provide safe care with a person-centred approach as the foundation for encounters. Peripheral venous catheterization and intravenous cannulation are among the most common procedures in healthcare. Additionally, needle procedures occur in various other interventions such as fetal diagnostics and tissue sampling. Up to 30% of adult patients expirience som fo

Emissions from road transport are one of the biggest health threats during the 21st century and are therefore being regulated with Euro standards. Part of the emissions from road transport originates from brakes and brake wear particle will therefore be included in the new standards. Brake system manufacturers will have to meet the new Euro standard and potentially reduce emissions from their prod