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To promote a more sustainable agricultural production, the European Commission implemented direct payments that require farmers to implement greening measures aimed at reducing negative effects of agriculture on the environment and biodiversity. These greening measures (including fallows and permanent grasslands) have been criticised for their potential inability to conserve biodiversity and promo
A sol-gel-based reverse-phase microarray was developed with improved sensitivity for prostatespecific antigen (PSA) from serum. The pore-sizecontrolled 3D sol-gel matrix was created with a large surface area to capture target molecules densely. Using the optically active sol-gel nanocomposites, human female serum was spiked with PSA and assessed using the reverse-phase protein microarray. The reve
We introduce an adaptive algorithm for sampling multivariate diffusion bridges that performs well for both diffusion and drift dominated models.The algorithm combines the residual bridge sampler with adaptive MCMC, allowing the algorithm to make online improvements upon the ordinary residual bridge algorithm.The simulation study show that the proposed bridge sampler is performing at least as good
Supplying food for the anticipated global population of over 9 billion in 2050 under changing climate conditions is one of the major challenges of the 21st century. Agricultural expansion and intensification contributes to global environmental change and risks the long-term sustainability of the planet. It has been proposed that no more than 15% of the global ice-free land surface should be conver
Parton showers have become a standard component in the description of high-energy collisions. Nowadays most final-state ones are of the dipole character, wherein a pair of partons branches into three, with energy and momentum preserved inside this subsystem. For initial-state showers a dipole picture is also possible and commonly used, but the older global-recoil strategy remains a valid alternati
Objective: To study whether locally administered recombinant inactivated human coagulation factor VIIa (FFR-rFVIIa) would reduce the thrombus formation and improve patency in an experimental venous thrombosis model without inducing systematic changes in the coagulation. Design: Experimental double-dummy randomised study. Materials: In 20 healthy New Zealand White rabbits both juguIar veins were ex
The energy distributions and the properties of the lower vacant electronic states in cobalt and nickel tetraphenylporphyrin complexes CoTPP and NiTPP are studied by X-ray absorption spectroscopy. Quasimolecular analysis of the experimental absorption spectra measured in the region of the 2p and 1s ionization thresholds of complexing metal atoms, as well as the 1s thresholds of ligand atoms (nitrog
Tissue Factor Pathway Inhibitor (TFPI) is a naturally occurring inhibitor of the TF-FVIIa induced coagulation in the presence of FXa. Recombinant two domain TFPI, where Asn 117 on the FXa-inhibitory domain was exchanged to a Gln yielding non-glycosylated TFPI (117QTFPI1-161), was evaluated regarding pharmacokinetics and delayed antithrombotic potential in the rabbit. Pharmacokinetic study 117QTFPI
We have earlier shown that both full-length and truncated glycosylated tissue factor pathway inhibitor (TFPI) lacking the third Kunitz domain and the c-terminal region has an antithrombotic effect comparable to low-molecular-weight heparin (LMWH) in an experimental venous thrombosis model. The aim of this study was to investigate whether a recombinant truncated non-glycosylated TFPI (117QTFPI1-161
Populärvetenskaplig sammanfattning1,7 miljoner nya fall av bröstcancer diagnosticeras årligen i världen. Bröstcancer är kvinnans vanligaste tumörsjukdom och i västvärlden samt Sverige kommer var åttonde till var nionde kvinna att insjukna under sin livstid. Överlevnaden efter bröstcancer är bland de högsta i världen i Sverige, med femårsöverlevnad på cirka 90%. För de kvinnor som diagnosticeras i Most patients with breast cancer present with low-risk tumors, node-negative disease, and excellent prognosis. For these patients, routine axillary nodal staging by sentinel lymph node biopsy (SLNB) has no therapeutic benefit. For patients with limited sentinel lymph node metastasis, completion axillary nodal dissection is controversial. Furthermore, those with heavy-burden metastasis could benefi
Dual system models postulate two distinct neural mechanisms for the processing of inflected words: irregular forms (e.g. ‘went’) are assumed to be directly accessed as whole word representations, whereas regularly inflected items (e.g. ‘played’) might undergo rule-based decomposition (Pinker & Ullman, 2002). Irregular verb stems incorrectly carrying a regular inflectional suffix have been repo
