The genetics of β-cell function (BCF) offer valuable insights into the aetiology of type 2 diabetes (T2D)1,2. Previous studies have expanded the catalogue of BCF genetic associations through candidate gene studies3–7, large-scale genome-wide association studies (GWAS) of fasting BCF8,9 or functional islet studies on T2D risk variants10–14. Nonetheless, GWAS focused on BCF traits derived from oral

Wheat straw (WS) constitutes a considerable biomass resource and can be used to produce the energy carrier methane through anaerobic digestion. Due to the low contents of several nutrient elements and water in harvested WS, the use of sewage sludge (SS), consisting of primary sludge and waste-activated sludge, as a nutrient source in co-digestion with steam-pretreated wheat straw (PWS) was investi

It has been widely reported that isoprene emissions from the Arctic ecosystem have a strong temperature response. Here we identify sedges (Carex spp. and Eriophorum spp.) as key contributors to this high sensitivity using plant chamber experiments. We observe that sedges exhibit a markedly stronger temperature response compared to that of other isoprene emitters and predictions by the widely accep

Background: Unexpected prolongation of first-line coagulation tests, including activated partial thromboplastin time (APTT), should trigger further work-up by performing mixing tests to elucidate the underlying cause, direct further specific testing and clarify their possible clinical impact. The aim of our study was to assess whether methodological diversity has any impact on the APTT mixing test

This article examines how the potato is used as a crisis strategy and future practiceby a group of actors from a youth education center in Skåne, with connections to alternativeagricultural movements, hereunder among others the permaculture movementand the grassroots movement Potatisuppropet. The article is a derivative effectof the dissertation project, Living Alternative Futures: Mobilising thro

In healthy individuals, a delicate balance between pro- and anticoagulant systems ensures efficient hemostasis and an open vascular system. As sites of vascular damage, a series of procoagulant reactions take place, which are carefully controlled by several anticoagulant proteins. Circumstantial and genetic risk factors increase the risk of venous thrombosis. Circumstantial risk factors are usuall

BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic precursor conditions to multiple myeloma and related disorders. Smoldering multiple myeloma is distinguished from MGUS by 10% or greater bone marrow plasma cells (BMPC) on sampling, has a higher risk for progression, and requires specialist management.OBJECTIVE: To develop a

Questions: Tree line ecotone regions are expected to respond swiftly to climate changes. In this paper, remote sensing- and ground-based tree population data are used to examine past and on-going changes of the tree line ecotone in a sub-arctic region characterized by precipitation increase. Questions addressed are: (1) at what rate has the tree line ecotone changed since the mid-20th century; (2)

A regression was established according to Wald's method for the estimation of forest productivity in the study area. A correlation of 0.58 was found between productivity (m3sk/ha/year) and TM4/TM3. The 198 compartments which were included in the study were divided into four groups on basis of their productivity. The correlation between observed productivity and estimated productivity was 0.59. The

Earth observation data provide useful information for the monitoring and management of vegetation- and land-related resources. The Framework for Operational Radiometric Correction for Environmental monitoring (FORCE) was used to download, process and composite Sentinel-2 data from 2018–2020 for Uganda. Over 16,500 Sentinel-2 data granules were downloaded and processed from top of the atmosphere re

Published in 1892, St. George Jackson Mivart’s remarkably original article ‘Happiness in Hell’ was placed on the Index Librorum Prohibitorum almost immediately. In his article, Mivart proposed a solution to the problem of hell whose core contention is that hell is horrible only from a heavenly point of view. From a this-worldly point of view, by contrast, hell is a place of breathtaking felicity. Published in 1892, St. George Jackson Mivart’s remarkably original article ‘Happiness in Hell’ was placed on the Index Librorum Prohibitorum almost immediately. In his article, Mivart proposed a solution to the problem of hell whose core contention is that hell is horrible only from a heavenly point of view. From a this-worldly point of view, by contrast, hell is a place of breathtaking felicity.

INTRODUCTION: Impaired renal function as seen in chronic kidney disease (CKD) is a known risk factor for coronary artery diseases and has been linked to inferior outcome after myocardial revascularization. Studies on the outcome of coronary bypass grafting (CABG) in CKD-patients are scarce. We aimed to study this subgroup of patients following CABG in a well defined whole-nation cohort, focusing o

Background: Tissue stiffness, dictated by organisation of interstitial fibrillar collagens, increases breast cancer risk and contributes to cancer progression. Tamoxifen is a standard treatment for receptor-positive breast cancer and is also aproved for primary prevention. We investigated the effect of tamoxifen and its main metabolites on the breast tissue collagen organisation as a proxy for sti

The Arctic-Boreal region is projected to experience spatially divergent trends in snow depth following climate change. However, the impact of these spatial trends has remained largely unexplored, despite potentially large consequences for the carbon cycle. To address this knowledge gap, we forced a customised arctic version of the dynamic vegetation model LPJ-GUESS with daily CMIP6 outputs from a The Arctic-Boreal region is projected to experience spatially divergent trends in snow depth following climate change. However, the impact of these spatial trends has remained largely unexplored, despite potentially large consequences for the carbon cycle. To address this knowledge gap, we forced a customised arctic version of the dynamic vegetation model LPJ-GUESS with daily CMIP6 outputs from a

BACKGROUND: A significant proportion of people with migraine do not achieve sufficient relief of their acute migraine symptoms with the currently available medications. A previous study showed that intranasal evaporative cooling reduced headache and migraine-associated symptoms when given in an outpatient clinic setting. This study aimed to evaluate the feasibility of self-administering the same i

Inledningsvis redogörs för Svenska Diakonsällskapets bakgrund och historiska rötter liksom för Diakonanstaltens initiering i Gävle. Bland annat ges som bakgrund en övergripande redogörelse för hur sociala förhållanden liksom den lutherska samhällssyn som dominerat det svenska enhetssamhället förändrades under 1800-talet. Dessa förändringar utgör en viktig kontext till förståelse av diakonins etabl