Photodynamic therapy (PDT) is one of the most interesting methods of photo treatment. In general, PDT is a modality for the treatment of non-muscle invasive tumors. PDT is very well suited in managing bladder cancer, as the bladder is accessible by endoscopy and the tumors are most often limited to the mucosa or sub-mucosa. PDT is likely more useful for patients with recurrent tumors after convent

Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the con

Background: The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor activity via inhibition of tumor angiogenesis in human and rodent tumors. To further explore the mode of action of tasquinimod, in vitro and in vivo experiments with gene microarra

The sex pheromone of the navel orangeworm, Amyelois transitella (Walker) (Lepidoptera: Pyralidae), consists of two different types of components, one type including (11Z,13Z)-11,13-hexadecadienal (11Z,13Z-16:Ald) with a terminal functional group containing oxygen, similar to the majority of moth pheromones reported, and another type including the unusual long-chain pentaenes, (3Z,6Z,9Z,12Z,15Z)-3,

We present a 2nd-order 4-bit continuous-time (CT) delta-sigma modulator (DSM) employing a 2nd-order loop filter with a single operational amplifier. This choice strongly reduces the power consumption, since operational amplifiers are the most power hungry blocks in the DSM. The DSM has been implemented in a 65 nm CMOS process, where it occupies an area of . It achieves an SNDR of 64 dB over a 500

Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European anc

Popular Abstract in Swedish Fetma har blivit ett växande folkhälsoproblem under de senaste decennierna och den epidemiartade utvecklingen har fått stor uppmärksamhet. Faktum är att världshälsoorganisationen WHO uppger att 1.4 miljarder människor är överviktiga och att 65 % av jordens befolkning lever i länder där fler dör av övervikt och fetma än av undervikt. Fetma är nära kopplat till hjärt- ochIn obesity and several other disease scenarios, the measurement of fat accumulation in various organs and tissues has become a sought-after technique in clinical diagnostics and research. Especially, quantitative and non-invasive techniques which also provide images of accumulated fat throughout the body would be valuable. In the typical hospital, magnetic resonance imaging (MRI) is the only techn

Popular Abstract in Swedish Tuberkulos (tbc) är en av de sjukdomar som sedan tusentals år orsakat mest lidande för mänskligheten. Mycobacterium tuberculosis är den bakterie som orsakar tbc hos människor. Att vi lever tätare inpå varandra på grund av växande befolkning globalt gör att denna luftburna smitta kan fortleva. Fattigdom och undernäring är viktiga bidragande orsaker som förklarar varför dRapid, accurate diagnosis and management of TB in HIV-positive individuals is critical for the success of antiretroviral treatment programmes in primary health care in Sub-Saharan Africa. These studies aim to develop and evaluate methods for TB case finding in adults receiving care at Ethiopian health centres. The prevalence of active TB in a prospective cohort of 812 HIV-positive adults was deter

This paper presents the electron and photon energy calibration achieved with the ATLAS detector using about 25 fb(-1) of LHC proton-proton collision data taken at centre-of-mass energies of root s = 7 and 8 TeV. The reconstruction of electron and photon energies is optimised using multivariate algorithms. The response of the calorimeter layers is equalised in data and simulation, and the longitudi

A porphyrin -system has been modulated by enhancing the push-pull character with highly asymmetrical substitution for dye-sensitized solar cells for the first time. Namely, both two diarylamino moieties as a strong electron-donating group and one carboxyphenylethynyl moiety as a strong electron-withdrawing, anchoring group were introduced into the meso-positions of the porphyrin core in a lower sy

Paleomagnetic and mineral magnetic analyses were carried out on Miocene clays from upper unit II at Sites M0027 and M0028 recovered during Integrated Ocean Drilling Program Expedition 313 on the New Jersey shallow shelf. A zone of mixed polarity in the lower section of Hole M0028A and dual overlapping magnetization components in upper Hole M0027A indicate that the sediments may have been chemicall

The main question that guides this paper is how governments are focusing (and must focus) on competence building (education, training and skills) when designing and implementing innovation policies. After a brief literature review, this paper suggests a typology of internal/external and individual/organizational sources of competences that are related to innovation activities. This serves to exami

Background: Available evidence suggest that perceptions or ratings of the neighborhood, e.g. as being green, walkable or noisy, are important for effects on health and wellbeing, also after controlling for objective measures of identical or similar features. When evaluating effects of the perceived environment, it is important that measurement properties and the reliability of the environmental ra

We propose a new description of the jet quenching phenomenon observed in nuclear collisions at high energies in which coherent parton branching plays a central role. This picture is based on the appearance of a dynamically generated scale, the jet resolution scale, which controls the transverse resolution power of the medium to simultaneously propagating color probes. Since from the point of view

Popular Abstract in Swedish Introduktion I Sverige dör i genomsnitt 4 personer i självmord dagligen vilket gör detta till en av de absolut vanligaste dödsorsakerna bland unga människor. Varje självmord föregås av ofattbart mänskligt lidande och innebär en tragedi för de anhöriga. Antalet självmordsförsök som kommer till vårdens kännedom är cirka 9000 varje år, men det finns ett stort mörkertal. BaRisk assessment of suicidal behaviour is one of the most important tasks in clinical psychiatry and a major determinant of subsequent care and treatment selections. To date, suicide risk assessment is based solely on clinical evaluations, which inevitably leads to subjective interpretations and decisions by the psychiatrist. In order to find more robust instruments in the evaluation of suicidality

Antifreeze proteins (AFPs) prevent uncontrolled ice formation in organisms exposed to subzero temperatures by binding irreversibly to specific planes of nascent ice crystals. To understand the thermodynamic driving forces and kinetic mechanism of AFP activity, it is necessary to characterize the hydration behavior of these proteins in solution. With this aim, we have studied the hyperactive insect

Objectives: Blood haemoglobin (Hb) concentration declines in elderly men, whilst the level of the adipocyte-derived protein adiponectin increases with age. The association between erythropoiesis and adiponectin in elderly men is unclear. The aim of this study was to determine whether adipokines such as adiponectin and leptin are associated with anaemia and Hb concentration in elderly community-dwe