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The efficacy of cancer immunotherapy relies on the recruitment and activation of cytotoxic T cell responses against solid tumors by type 1 conventional dendritic cells (cDC1s). However, the generation of cDC1s for cancer immunotherapy faces significant limitations, including poor cell yield, functional heterogeneity, and susceptibility to immunosuppression in the tumor microenvironment (TME). We r
• Purpose: Controversy exists regarding the comparative efficacy of collagenase injection and percutaneous needle fasciotomy in the treatment of Dupuytren contracture. The randomized controlled trials (RCTs) that have compared the two treatment methods have reported results mostly implying similar treatment efficacy, durability, and complications. We aimed to review these RCTs regarding methodical
After World War II, the ethno-demographic structure of many cities in eastern and central Europe was fundamentally changed as a result of genocides, ethnic cleansing, deportations and migrations. The cultural diversity that had been characteristic of many of those cities was radically reduced, as new inhabitants tried to find their place in the cityscapes. In focus of this thesis is thememory work
Flux equations describing brain D-glucose uptake are presented for up to four tissue compartments: blood, endothelial intracellular space in the blood-brain barrier (BBB), extravascular-extracellular space (EES), and intracellular space. Transport rates are described by Michaelis-Menten kinetics, including half-saturation constants ( K T ) and maximum rates for transport ( T max )
Restoring cultivated peatlands has become a silver bullet in climate change mitigation policies globally due to peatlands’ potentials to sequester carbon. In Denmark, carbon is the focal point for such interventions but simultaneously conspicuous by its absence in local restoration efforts. Scientific abstractions render carbon visible through maps and models presenting soil’s carbon content, emisRestoring cultivated peatlands has become a silver bullet in climate change mitigation policies globally due to peatlands’ potentials to sequester carbon. In Denmark, carbon is the focal point for such interventions but simultaneously conspicuous by its absence in local restoration efforts. Scientific abstractions render carbon visible through maps and models presenting soil’s carbon content, emis
OBJECTIVE: Infective native aneurysms of the femoropopliteal arteries (INA-FPs) are rare and mostly reported in intravenous drug users (IVDU). This study aimed to summarize all cases of INA-FPs presented in the literature, to describe patient characteristics, microbiology, treatments and outcomes, and compare IVDU with non-IVDU patients.METHODS: A systematic search of PubMed, ScienceDirect, Embase
Introduction Data are lacking about the risk for death and major adverse cardiovascular events (MACE) after transcatheter aortic valve implantation (TAVI), compared to the general population. Therefore, we assessed the risk for all-cause death and MACE after TAVI in patients aged 65 years and older, in comparison to an age- and sex-matched control population. Methods and results In total, 5924 TAV
Easy, low‐threshold access is widely regarded as a major advantage of online services. In Sweden, several municipalities are striving to increase the accessibility of their social services by responding to anonymous users online. This article considers the nature of the accessibility of these online services. Two online platforms were studied: (quasi‐)synchronous online chats and asynchronous onli
BACKGROUND: Low back pain (LBP) is a leading cause of work absence globally. Digital interventions have the potential to increase access to self-management support for individuals with persistent LBP.OBJECTIVE: This study aims to evaluate the feasibility, usability, and acceptability of a digital educational program (MyRelief) designed to support self-management strategies for people with persiste
BACKGROUND: Plasmodium falciparum causes the deadliest form of malaria, which remains one of the most prevalent infectious diseases. Unfortunately, the only licensed vaccine showed limited protection and resistance to anti-malarial drug is increasing, which can be largely attributed to the biological complexity of the parasite's life cycle. The progression from one developmental stage to another i
Mental well-being and excessive alcohol consumption each represent a significant public health concern, and evidence suggests an association between them. Furthermore, drinking motivations associated with harmful drinking have been studied, but not systematically in the UK population. A representative sample of 6174 UK adults aged 18⁻75 were surveyed online. Low risk drinkers were found to have hi
A study of strange hadron production associated with hard scattering processes and with the underlying event is conducted to investigate the origin of the enhanced production of strange hadrons in small collision systems characterised by large charged-particle multiplicities. For this purpose, the production of the single-strange meson KS0 and the double-strange baryon Ξ± is measured, in each even
Background A better characterization of diabetic retinopathy (DR) may be helpful to monitor early disease, predict progression of DR, and to evaluate new treatment strategies. Visual function has been suggested to complement the assessment of microvascular lesions in DR but needs to be evaluated in longitudinal studies. Objectives This prospective longitudinal cohort study investigated whether ear
Context. A gravitational wave (GW) passing through an astrometric observer causes periodic shifts of the apparent star positions measured by the observer. For a GW of sufficient amplitude and duration, at a suitable frequency, these shifts might be detected with a Gaia-like astrometric telescope. Aims. This paper is aimed at making a detailed analysis of the effects of GWs on an astrometric soluti
