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Modelica allows systems to be described with reuseable components and with a high precision. To be able to use such complex models efficiently, high demands are set on tools that allow the user to extract the information needed from the models in a straight-forward manner. For this purpose, design-of-experiments techniques can be used to systematically analyze the complex models.In this paper, it
Background: High-density Lipoprotein (HDL) attenuates endothelial cell apoptosis induced by different cell-death stimuli such as oxidation or growth factor deprivation. HDL is the main plasma carrier of the bioactive lipid sphingosine 1-phosphate (S1P), which it is a signaling molecule that promotes cell survival in response to several apoptotic stimuli. In HDL, S1P is bound to Apolipoprotein M (A
Pepper spray (OC) is a policing tool aimed to prevent or stop aggressive behavior by quickly and temporarily incapacitate without injuring. To date, few studies have investigated OC’s operational usefulness and limitations. OC reduced violent behavior in 93% of the 936 incidents investigated. However, the operative range was often <2 m and it took between 3 and 5 s of spraying before obtaining eff
Control applications contain both logic, sequencing, and control algorithms. A holistic view of this is seldom presented in teaching and papers. One reason is the separation of communities -- automation groups typically come from the Programmable Logic Controller (PLC) world while control engineers primarily come from the Distributed Control System (DCS) world. Both logic, sequencing, and control
Objective: To assess the complete vascular risk factor (VRF) profile of idiopathic normal pressure hydrocephalus (INPH) using a large sample of representative patients with INPH and population-based controls to determine the extent to which vascular disease influences INPH pathophysiology. Methods: All patients with INPH who underwent shunting in Sweden in 2008-2010 were compared to age- and sex-m
Quantum mechanical weak values of projection operators have been used to answer which-way questions, e.g. to trace which arms in a multiple Mach–Zehnder setup a particle may have traversed from a given initial to a prescribed final state. I show that this procedure might lead to logical inconsistencies in the sense that different methods used to answer composite questions, like “Has the particle t
Today, we can see a trend toward increased psychosocial strain at work among home-care managers and staff. The aim of this study is to describe home care managers' views on their own psychosocial working conditions and on how to promote workplace health and safety in a municipality in northern Sweden. A mixed-methods design was used, including questionnaire and qualitative focus group data. The qu
WNT5A is a secreted, noncanonical WNT signaling protein that has been reported to promote progression of several types of cancer, including oral squamous cell carcinoma. Many WNT5A antibodies are available commercially for immunohistochemistry (IHC) and western blot analysis. Validation of the primary antibodies, however, is often neglected. We characterized antibodies for detecting WNT5A by IHC a
Objectives Biologic agents have dramatically changed treatment of rheumatoid arthritis (RA). To date only scarce head-To-head data exist especially when the biological therapies are given as monotherapy without concomitant disease modifying drugs (DMARDs). Thus the objective of the current study is to evaluate treatment response of all available biological therapies with special focus on utility (
We present a rigorous phase noise analysis of a generic harmonic oscillator where the active core can be modeled as a transconductor. Phase noise equations are derived without any specific assumption on the nature of the resonator in the oscillator; furthermore, we provide closed-form 1/f2 phase noise equations when the resonator consists of an arbitrary number of cascaded LC tanks, each tuned at
A robotic assembly task is usually implemented as a sequence of simple motions, and the transitions between the motions are made when some events occur. These events can usually be detected with thresholds on some signal, but faster response is possible by detecting the transient on that signal. This paper considers the problem of detecting these transients. A force-controlled assembly task is use
Multiple prognostic tools are used to evaluate prognosis for comatose survivors resuscitated after cardiac arrest (CA). Next to the clinical neurologic examination, electroencephalography (EEG) is the most commonly used method to assess prognosis. However, the reliability of EEG has been limited by varying classification systems, interrater variability, and the influence of sedation. Another impor
Cardiac arrest (CA) survivors may experience cognitive, physical, or emotional problems that can affect their return to everyday activities and quality of life. To improve longterm outcomes, interventions after hospital discharge may be needed. A follow-up plan to identify CA survivors with increased risk of residual cognitive, physical, or emotional problems is important to target interventions a
Background/Objectives:Obesity and low physical fitness are known risk factors for ischemic heart disease (IHD), but their interactive effects are unclear. Elucidation of interactions between these common, modifiable risk factors may help inform more effective preventive strategies. We examined interactive effects of obesity, aerobic fitness and muscular strength in late adolescence on risk of IHD
Objective. To study longterm work disability and possible predictors in newly diagnosed patients with primary Sjogren syndrome (pSS). Methods. Because we wanted to include only patients with full work availability potential, eligible patients were aged 18-62 years. Fifty-one patients (mean age 46 yrs, range 18-61 yrs, 50 women) diagnosed with pSS between January 2001 and December 2012 were include
In this study, we combine conventional qualitative approaches with a more novel approach, participatory art, to explore local perceptions of land-use change and future aspirations for development in two communities in Kilombero Valley, Tanzania. We concentrate on the effects of large-scale land acquisitions on people and the environment in an ecologically important area. Leasing of land to foreign
A new method is developed to synthesize organic microsphere-supported polymer brushes for affinity separation of saccharides and glycoproteins. In the first step, crosslinked polymer microspheres are synthesized using atom transfer radical polymerization (ATRP). The terminal ATRP initiators on the microspheres are used to graft polymer brushes from propargyl acrylate and N-isopropyl acrylamide. Th
Background: Smoldering multiple myeloma (SMM) is an indolent disease stage, considered to represent the transition phase from the premalignant MGUS (Monoclonal Gammopathy of Undetermined Significance) state towards symptomatic multiple myeloma (MM). Even though this diagnosis provides an opportunity for early intervention, few treatment studies have been done and the current standard of care is ob
Several monogenic causes of familial myelodysplastic syndrome (MDS) have recently been identified. We studied two families with cytopenia, predisposition to MDS with chromosome 7 aberrations, immunodeficiency, and progressive cerebellar dysfunction. Genetic studies uncovered heterozygous missense mutations in SAMD9L, a tumor suppressor gene located on chromosome arm 7q. Consistent with a gain-of-f
Context. High resolution stellar spectral atlases are valuable resources to astronomy. They are rare in the 1-5 μm region for historical reasons, but once available, high resolution atlases in this part of the spectrum will aid the study of a wide range of astrophysical phenomena. Aims. The aim of the CRIRES-POP project is to produce a high resolution near-infrared spectral library of stars across
