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Development of celiac-safe foods : prevention of transglutaminase 2 (TG2) deamidation of gluten in healthy non-celiac volunteers
In celiac disease, intestinal transglutaminase (TG2) produces immunogenic peptides by deamidation of gluten proteins. These products drive the celiac immune response. We have previously identified an interaction between gliadin and a food additive, E304i, which prevents gliadin processing (both deamidation and transamidation) by TG2, in vitro. In this study, we investigated if E304i could prevent
Effects of Self-Legitimation and Delegitimation on Public Attitudes toward International Organizations : A Worldwide Survey Experiment
Public views on international organizations (IOs) have become a matter of central concern. While actors in world politics increasingly try to legitimize or delegitimize IOs, scholars have begun investigating such phenomena systematically. This paper provides the most comprehensive IO (de)legitimation study to date. Building on cueing theory, and considering input as well as output legitimacy, I ex
The pitfalls and potential of citizen science in ornithology
ERS International Congress 2023 : highlights from the Airway Diseases Assembly
In this review, early career and senior members of Assembly 5 (Airway Diseases, Asthma, COPD and Chronic Cough) present key recent findings pertinent to airway diseases that were presented during the European Respiratory Society International Congress 2023 in Milan, Italy, with a particular focus on asthma, COPD, chronic cough and bronchiectasis. During the congress, an increased number of symposi
Progressive QTc prolongation and reduced heart rate variability in dementia with Lewy bodies compared to Alzheimer's disease
Introduction: Autonomic dysfunction (AuD) is a significant clinical challenge in patients with Dementia with Lewy Bodies (DLB). Manifestations of AuD such as orthostatic hypotension (OH) is associated with falls and decreased quality of life. Cardiac autonomic denervation is an early phenomenon in DLB and a potential contributor to OH. This retrospective study was undertaken to explore whether rou
Jacobi’s Burden : “Jewish” Figurations in Fanny och Alexander
Newborn screening in metachromatic leukodystrophy – European consensus-based recommendations on clinical management
Introduction: Metachromatic leukodystrophy (MLD) is a rare autosomal recessive lysosomal storage disorder resulting from arylsulfatase A enzyme deficiency, leading to toxic sulfatide accumulation. As a result affected individuals exhibit progressive neurodegeneration. Treatments such as hematopoietic stem cell transplantation (HSCT) and gene therapy are effective when administered pre-symptomatica
Facing and dealing with emotional turbulence : Living with newly diagnosed Parkinson's disease
Introduction: The experiences of living with Parkinson's disease (PD) from the perspective of newly diagnosed persons with PD (PwPD) have not been previously described. Aim: This study aimed to gain a better understanding of the impact of living with the early stages of PD. Methods: A qualitative interview study was conducted among nine persons, seven men and two women, from southern Sweden. Parti
Quantifying empirical support for theories of consciousness : a tentative methodological framework
Understanding consciousness is central to understanding human nature. We have competing theories of consciousness. In interdisciplinary consciousness studies most believe that consciousness can be naturalized (i.e., consciousness depends in some substantial way on processes in — or states of — the brain). For roughly two decades, proponents of almost every theory have focused on collecting empiric
Primary prophylaxis implementation and long-term joint outcomes in Swedish haemophilia A patients
Introduction: Primary prophylaxis is the gold standard in severe haemophilia A (SHA) but time to escalate the prophylaxis regimen varies. Aim: Assess prophylaxis implementation and long-term joint health outcomes in SHA with primary prophylaxis. Methods: Adult male patients born after 1980, with SHA on primary prophylaxis, started before the age of 3 years and second joint bleed, and no history of
Optimal microphone selection for aero-engine acoustic measurement
Acoustic testing is crucial in the aero-engine design process, providing valuable information about the sound field in terms of acoustic modes. The conventional use of a uniform sampling array limits the achievable resolution for a given number of sensors, necessitating the use of a large number of sensors to achieve high-resolution estimates. This limitation may be overcome using a non-uniform se
Staphylococcus aureus bacteraemia, cardiac implantable electronic device, extraction, and the risk of recurrent infection; a retrospective population-based cohort study
Background: Patients with cardiac implantable electronic device (CIED) and Staphylococcus aureus bacteraemia (SAB) are at risk of having CIED infection, pocket infection or endocarditis. To avoid treatment failures, guidelines recommend that the CIED should be extracted in all cases of SAB butrecent studies indicate low extraction rates and low risk of relapse. The aim of the study was to describe
Prevalence and disease disability in immigrants with multiple sclerosis in Malmö, southern Sweden
Background: Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central nervous system and the major non-traumatic cause of permanent disability in young adults. Several migration studies have been performed over the years suggesting a pattern of higher disease disability in certain ethnic groups. To our knowledge, differences in disease progression in immigrants have n
Application of emission spectroscopy in plasma-assisted NH3/air combustion using nanosecond pulsed discharge
This work investigates the effects of atmospheric-pressure nanosecond (ns) pulsed plasma discharges on NH3/air flames using optical emission spectroscopy (OES). Firstly, spatially-resolved OES in the 200–800 nm range of NH3/air flames with and without discharges are presented to identify the plasma-induced excited species (such as N2* and H*). Then, time-resolved OES with ns timescale resolution a
A novel quinoline with airway relaxant effects and anti-inflammatory properties
Background: In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad range of pharmacological properties. Here, we investigated the airway relaxant and anti-inflammatory properties of a novel quinoline (RCD405). Methods: The airwa
Electrifying equality: How electricity adoption boosted inclusive growth in early 20th century Sweden
When new general-purpose technologies like AI emerge, both techno-optimists and techno-pessimists predict that inequality will increase among the labour force. This column studies the rapid introduction of electricity in early 20th century Sweden and its effect on workers. The transformative technology benefitted those at the bottom of the income distribution, resulting in higher incomes, lower in
Alpha spectrometry of radioactive aerosols from the European Spallation Source : an investigation of the possibilities of direct alpha spectrometry
Effects of Coumarins from Roots of Paramignya scandens (Griff.) Craib on LPS-induced IL-1β and IL-10 Cytokine Production in RAW 264.7 Macrophages
Based on our previous study, we evaluated the modulatory effects on LPS-induced IL-1β and IL-10 cytokine production in RAW 264.7 macrophages of several medicinal herbs, including P. scandens. The results showed that P. scandens extract showed significant effects on LPS-induced IL-1β and IL-10 cytokine production in RAW 264.7 macrophages. Therefore, in the current research, we focused on the P. sca
LOCALLY CONSERVATIVE AND FLUX CONSISTENT ITERATIVE METHODS
Conservation and consistency are fundamental properties of discretizations of conservation laws, necessary to ensure physically meaningful solutions. In the context of systems of nonlinear hyperbolic conservation laws, conservation and consistency additionally play an important role in convergence theory via the Lax-Wendroff theorem. Here, these concepts are extended to the realm of iterative meth