Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identifica

Algoritmer är en bärande del av internets infrastruktur som påverkar allt från vilken musik vi får rekommenderad till oss eller vems inlägg som blir synliga för oss i sociala medier, till mer avgörande beslutsfattande processer i offentlig förvaltning. I den här rapporten presenteras resultatet av en studie som utförts inom ramen för Kungliga bibliotekets projekt Digitalt först med användaren i fo

Many computer vision tasks require the implementation of robust and efficient target tracking algorithms. Furthermore, in robotic applications these algorithms must perform whilst on a moving platform (ego motion). Despite the increase in computational processing power, many engineering algorithms are still challenged by real-Time applications. In contrast, lightweight and low-power flying insects

The growing interest in using population balance modeling to describe emulsification processes has spurred an interest in experimentally measuring the breakup frequency. This contribution classifies, compares, and critically reviews the different methods that have been suggested for measuring the breakup frequency, applicable to emulsification devices. Two major approaches can be seen in previous

Right atrial thrombosis is a rare, but potentially serious complication of acute lymphoblastic leukemia treatment. We conducted a retrospective multicenter study to assess the incidence, treatment, and outcome of asymptomatic right atrial thrombosis detected at routine echocardiography of children after acute lymphoblastic leukemia treatment in the Nordic and Baltic countries. Eleven (2.7%, 95% co

Critical discussion of proposed Dutch real estate tax exemption for first time home buyers and the negative effects for the housing market and equality of the existing gift tax exemption related to residential real estate.

Cloud-RAN (C-RAN) is a promising paradigm for the next generation radio access network infrastructure, which offers centralized and coordinated base-band signal processing. On the other hand, this requires extremely low latency fronthaul links to achieve real-time centralized signal processing. In this paper, we investigate massive MIMO pilot scheduling in a C- RAN infrastructure. Three commonly u

Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the effects of ex vivo MSC exposure to

In this paper we analyze how sampling instant error affects the receiver performance in raised-cosine filtered DS-CDMA systems. An expression is presented for the Signal to Inter Chip Interference (S/ICI) ratio as a function of the sampling error characteristics and Raised-cosine roll-off factor. Finally, we use the analysis in the paper to derive sufficient sampling resolution for the high perfor

This study deals with the Swedish cultural heritage in the United States and aims to examine how and why individuals living in the U.S. select and affirm certain concepts and phenomena as particularly Swedish. The focus is on Lindsborg, Kansas, a town of some 3,000 inhabitants who identify themselvesas Swedish Americans, Swedes, and non-Swedes, and on how they organize, prepare and enact parades i

Den klädda kroppens identiteter och förvandlingar lockar i modets metamorfoser en read nordiska akademiska skribenter att skriva om kläder, mode, kropp; om kläder mode och plats liksom om mode och makt. Tanken med boken är att överbrygga den polarisering som ibland görs mellan kläder och mode, men också studera kulturella processer om hur identitet kan baseras på något materiellt som just plagg.

Background: Women with idiopathic pulmonary arterial hypertension (IPAH) have been found to have a worse haemodynamic status at diagnosis, but better survival than men. Over the past decade, demographics have changed and new treatments have become available. The objective of this study was to investigate sex differences in an incident IPAH population diagnosed between 2008 and 2016.Methods: Differ

Background: Inferior placement of a femoral stem is predictive for early loosening and failure, but does restoration of the original hip anatomy benefit the function and survival of a total hip replacement? Methods: Seventy-five patients with primary unilateral hip osteoarthritis operated with an uncemented anatomical stem were randomized for either standard or modular stems. We used 50 ABG II ste

DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation-age interaction analysis using 1,230 early-stage lung adenocarcinoma patients from five cohorts. A Cox proportional hazards model was used to investigate lung

Even though insects have comparably small brains, they achieve astoundingly complex behaviors. One example is flying moths tracking minute amounts of pheromones using olfactory circuits. The tracking distance can be up to 1 km, which makes it essential that male moths respond efficiently and reliably to very few pheromone molecules. The male-specific macroglomerular complex (MGC) in the moth anten

We study the Ginzburg–Landau model in the frame of non-homogeneous magnetic permeabilities and non-homogeneous applied magnetic fields. We establish a continuity result with respect to the applied magnetic field and the magnetic permeability coefficient, thereby motivating the consideration of a discontinuous magnetic field/permeability within the sample. We then study the model in the regime of a