Sökresultat

Filtyp

Din sökning på "*" gav 529814 sökträffar

Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient

'Relationships based on love and relationships based on needs': Emerging trends in youth sex culture in contemporary urban Vietnam

This paper addresses one of the important dimensions of the experience of youth in contemporary urban Vietnam; that is their sexual practices, behaviour and attitudes. Within a conceptual framework that focuses on sexuality and social change in a modernising and increasingly open society, and based on data collected from ethnographic fieldwork in Hanoi from 1999 to 2004., this paper describes an e

Micro processes of learning: exploring the interplay between conceptions, meanings and expressions

The article describes qualitative variation in micro processes of learning, focusing the dynamic interplay between conceptions, expressions and meanings of expressions in students' learning in higher education. The intentional-expressive approach employed is an alternative approach to the function of language use in learning processes. In the empirical investigation, a dialogue model was used that

A new strategy for solving fluid-structure problems

A scheme for treating unsymmetrical coupled systems is outlined. Such systems occur naturally in connection with fluid-structure interaction, where an acoustic fluid is contained in an elastic structure. The discretization is performed by means of the finite element method, using displacement formulation in the structure and either pressure or displacement potential in the fluid. Based on the eige

Flight performance in night-flying sweat bees suffers at low light levels.

The sweat bee Megalopta (Hymenoptera: Halictidae), unlike most bees, flies in extremely dim light. And although nocturnal insects are often equipped with superposition eyes, which greatly enhance light capture, Megalopta performs visually guided flight with apposition eyes. We examined how light limits Megalopta's flight behavior by measuring flight times and corresponding light levels and compari

The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.

Aims/hypothesis The receptor for AGE (RAGE) is considered to be mainly an intracellular signal-transducer or pro-inflammatory peptide of possible importance for inflammation and autoimmune diseases. Our aim was to study whether the -374 T/A polymorphism in the gene encoding RAGE (AGER) is associated with diabetes type and presence of diabetic complications. Methods The AGER -374 T/A polymorphism w

Effects of liming on ectomycorrhizal fungi infecting Pinus sylvestris L. 2. Growth-rates in pure culture at different ph values compared to growth-rates in symbiosis with the host plant

Growth rates of ectomycorrhizal fungi were measured in pure culture at pH 3-8 on MMN-agar and sterilized peat, with and without nutrients added. Mycorrhizas were synthesized with Pinus sylvestris L. seedlings and the growth rate of the external mycelium was measured in peat at pH 3.8 and 7.3. The fungi were three isolates of Piloderma croceum Erikss. & Hjorts., two isolates of an unidentified

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice.

OBJECTIVES: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme, dipeptidyl peptidase IV (DPPIV), are being explored in the treatment of diabetes. We examined the long-term influence of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J mice and such mice rendered glucose-intolerant and insulin-resistant by feeding a high-fat diet. DESIGN: In mice

Enzymatic degradation of model cellulose films

Enzymatic degradation of model cellulose films prepared by a spin-coating technique was investigated by ellipsometry. The cellulose films were prior to degradation characterized by ellipsometry, contact angle measurements, ESCA (electron spectroscopy for chemical analysis) and AFM (atomic force microscopy). At enzyme addition to preformed cellulose films an initial adsorption was observed, which w

Nutritional constraints on Sphagnum-growth and potential decay in northern peatlands

1 In a 4-year fertilization experiment we studied the effects of increased nitrogen (N) or phosphorus (P) supply on productivity and potential decay in the acrotelm of Sphagnum-dominated Swedish peatlands at northern (low atmospheric N input: low-N site) and southern (high atmospheric N input: high-N site) sites. 2 During the experimental period, there was a severe summer drought at the high-N sit

Increased expression of nitric oxide synthase in cultured neurons from adult rat colonic submucous ganglia

Neuronal plasticity in the enteric nervous system (ENS) is probably a key step in intestinal adaptation during growth, maturation and ageing as well as in several pathophysiological situations. Studies on cultured myenteric neurons have revealed an increased vasoactive intestinal peptide (VIP) expression in neuronal nitric oxide synthase (NOS)-expressing neurons. In addition, both VIP and nitric o

Productive Vocabulary Size Predicts Event-related Potential Correlates of Fast Mapping in 20-Month-Olds

Although it is well documented that children undergo a productive vocabulary spurt late in the second year, it is unclear whether this development is accompanied by equally significant advances in receptive word processing. In the present study, we tested an electrophysiological procedure for assessing receptive word learning in young children, and the impact of productive vocabulary size for perf

Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

Most myxoid liposarcomas (MLS) are characterized cytogenetically by a t(12;16)(q13;p11). It is reasonable to assume that this translocation corresponds to the consistent rearrangement of one or two genes in 12q13 and/or 16p11, and that the loci thus affected are important in the normal control of fat cell differentiation and proliferation. We have used Southern blot technique to test whether a gen

Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet NO generation in the mouse.

Aim: The role of islet nitric oxide (NO) production in insulin releasing mechanisms is unclear. We examined whether the beneficial effects of the imidazoline derivative RX 871024 (RX) on beta-cell function might be related to perturbations of islet NO production. Methods: Experiments were performed with isolated islets or intact mice challenged with glucose or carbachol with or without RX treatmen

The Evolution and Diversification of S-locus Haplotypes in the Brassicaceae Family.

Self-incompatibility (SI) in the Brassicaceae plant family is controlled by the SRK and SCR genes situated at the S locus. A large number of S haplotypes have been identified, mainly in cultivated species of the Brassica and Raphanus genera, but recently also in wild Arabidopsis species. Here, we used DNA sequences from the SRK and SCR genes of the wild Brassica species B. cretica, together with p

Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.

Aberrant activation of c-Kit is involved in a number of human diseases including cancers and leukemias. Certain receptor tyrosine kinases, such as epidermal growth factor receptor, have been shown to indirectly recruit Cbl through the adapter protein Grb2, leading to receptor ubiquitination and degradation. In order to study the role of Grb2 in c-Kit degradation, a series of mutations of the Grb2

Synthesis of branched 'nanotrees' by controlled seeding of multiple branching events

The formation of nanostructures with controlled size and morphology has been the focus of intensive research in recent years(1-10). Such nanostructures are important in the development of nanoscale devices and in the exploitation of the properties of nanomaterials(9). Here we show how tree-like nanostructures ('nanotrees') can be formed in a highly controlled way. The process involves the self-ass

Class, Community and Communicative Planning: Urban Redevelopment at King’s Cross, London

This paper presents an argument for considering issues of class in analyses of communicative planning projects. In these projects, class interests tend to be obscured by the contemporary preoccupation with the class-ambiguous category of “community”. Through a case study of a project of urban redevelopment at King’s Cross in London, we conceptualize and map class interests in an urban redevelopmen