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VBE i miljörätten?
Causal nature of neighborhood deprivation on individual risk of coronary heart disease or ischemic stroke : A prospective national Swedish co-relative control study in men and women
We studied the association between neighborhood socioeconomic status (SES) and incidence of coronary heart disease (CHD) or ischemic stroke in the total population and in full- and half-siblings to determine whether these associations are causal or a result from familial confounding. Data were retrieved from nationwide Swedish registers containing individual clinical data linked to neighborhood of
Design of DISCO—Direct or Subacute Coronary Angiography in Out-of-Hospital Cardiac Arrest study
Background Acute coronary syndrome is a common cause of out-of-hospital cardiac arrest (OHCA). In patients with OHCA presenting with ST elevation, immediate coronary angiography and potential percutaneous coronary intervention (PCI) after return of spontaneous circulation are recommended. However, the evidence for this invasive strategy in patients without ST elevation is limited. Observational st
Patient education-level affects treatment allocation and prognosis in esophageal- and gastroesophageal junctional cancer in Sweden
Background Low socioeconomic status and poor education elevate the risk of developing esophageal- and junctional cancer. High education level also increases survival after curative surgery. The present study aimed to investigate associations, if any, between patient education-level and treatment allocation after diagnosis of esophageal- and junctional cancer and its subsequent impact on survival.
Design of a rapid point-of-care immunoassay : Based on a single-step non-competitive immunoassay with magnetic permeability detection
This thesis describes the development of a one-step, specific, cost-effective and rapid in vitro point-of-care immunoassay test based on a unique magnetic immunoassay principle. The principle in question is based on a non-competitive heterogeneous immunoassay in a one-step analysis, relying on magnetic permeability detection. The heterogeneous immunoassay is performed in disposable reagent vials,
Comparison of hernia registries : the CORE project
Introduction: The aim of the international CORE project was to explore the databases of the existing hernia registries and compare them in content and outcome variables. Methods: The CORE project was initiated with representatives from all established hernia registries (Danish Hernia Database, Swedish Hernia Registry, Herniamed, EuraHS, Club Hernie, EVEREG, AHSQC) in March 2015 in Berlin. The foll
Efficacy and safety of outpatient treatment with direct oral anticoagulation in pulmonary embolism
Anticoagulant treatment of acute pulmonary embolism (PE) has traditionally been hospital-based. The lesser need for monitoring with the increasingly used direct acting oral anticoagulants (DOAC) in comparison to warfarin potentially facilitates outpatient treatment of PE with these drugs. This study aimed to evaluate efficacy and safety of outpatient treatment of PE with DOAC. We extracted data fr
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been identified as associated with BMD. To investigate the genetic determinants of TB-BMD variation alon
Current smoking is associated with a larger waist circumference and a more androgenic profile in young healthy women from high-risk breast cancer families
The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were completed by 269 healthy women from high-risk breast cancer families between 1996 and 2006 in Sweden. Blood samples for analyses of plasma testosterone, estradiol, androstenedione, sex hormone-b
Does Female Leadership Matter? An Analysis of Swedish Foreign Ministers and their Parliamentary Speeches, 1955–2016
The current Swedish Foreign Minister, Margot Wallström, has in her foreign policy statement claimed that a feminist foreign policy will be an integral part of activities throughout the Swedish Foreign Service. Even though an explicit ‘feminist foreign policy’ is a rather recent and ‘Swedish’ phenomenon, foreign policies in line with such a general ‘feminist’ agenda may have been implemented throug
SNPs related to vitamin D and breast cancer risk : A case-control study
Background: It has been suggested that vitamin D might protect from breast cancer, although studies on levels of vitamin D in association with breast cancer have been inconsistent. Genome-wide association studies (GWASs) have identified several single-nucleotide polymorphisms (SNPs) to be associated with vitamin D. The aim of this study was to investigate such vitamin D-SNP associations in relatio
Predictors of multiglandular disease in primary hyperparathyroidism
Background: Primary hyperparathyroidism (pHPT) is caused by single- or multiglandular disease (MGD). Patients with MGD have an increased risk of complications at surgery and for persistence and recurrence after surgery. The study evaluated whether preoperative clinical and biochemical characteristics could predict MGD in patients with pHPT. Methods: We retrospectively evaluated patients operated 1
A 2-year follow-up study of patients with pharyngotonsillitis
Background: Longtime follow-up studies on patients with pharyngotonsillitis are rare. We aimed to describe the patterns of new visits for a sore throat, complications and tonsillectomy during 2 years in a cohort of patients with pharyngotonsillitis and non-infected controls. Methods: A retrospective chart review was performed on a cohort of patients with acute sore throat (n = 207), and non-infect
High risk of hypogonadism in young male cancer survivors
Objective: Cancer and its treatment in childhood and young adulthood can cause hypogonadism, leading to increased risk of long-term morbidity and mortality. The aim of this study was to evaluate the risk of presenting with biochemical signs of hypogonadism in testicular cancer survivors (TCS) and male childhood cancer survivors (CCS) in relation to the type of treatment given. Design: Case-control
Sustained Psoriasis Area and Severity Index, Dermatology Life Quality Index and EuroQol-5D response of biological treatment in psoriasis : 10 years of real-world data in the Swedish National Psoriasis Register
Background: Few studies have analysed the long-term effects of biological treatment in psoriasis. PsoReg, the Swedish national register for systemic psoriasis treatment, started in 2006 and now includes 10 years of real-world data on the effectiveness of biological treatment. Objectives: To analyse the long-term real-world outcome data of patients who are biologically naïve with moderate-to-severe
Headache advances in 2017 : a new horizon in migraine therapy
From Copperplate to Color Lithography : On the Modernization of an Illustrated Flora 1800-1900
År 1900 blev botanisten Carl Lindman ansvarig för återutgivningen av en hundra år gammal illustrerad flora, J. W. Palmstruchs Svensk botanik (1802–43). De gamla handkolorerade kopparsticken undersöktes noggrant, korrigerades och försågs med nya förstorade detaljer och trycktes sedan med färglitografi. I denna artikel studeras, ur ett bokhistoriskt perspektiv, hur den nya formen påverkar innehålletIn 1900 the Swedish botanist Carl Lindman was assigned responsibility for the republication of a one-hundred-year old illustrated flora, J. W. Palmstruch’s Svensk botanik (1802–43). The old hand-colored copperplates were meticulously examined, corrected, and supplied with new magnified details and then printed in color lithographs. This article closely examines, from a book historical perspective,